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The combined cancer therapy of drug delivery and boron neutron capture therapy by boron-containing nanoparticles

Research Project

Project/Area Number 17H02738
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials chemistry
Research InstitutionKyoto University

Principal Investigator

Komatsu Naoki  京都大学, 人間・環境学研究科, 教授 (30253008)

Co-Investigator(Kenkyū-buntansha) 鈴木 実  京都大学, 複合原子力科学研究所, 教授 (00319724)
石川 善恵  国立研究開発法人産業技術総合研究所, 材料・化学領域, 主任研究員 (20509129)
天野 創  滋賀医科大学, 医学部, 助教 (20613467)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywordsがん / ホウ素 / 中性子 / 治療 / ナノ粒子 / がん中性子捕捉療法 / がん治療 / 薬物送達 / 腫瘍 / 蛍光 / 生体イメージング / 窒化ホウ素 / ポリグリセロール / ナノシート / 2次元材料 / ホウ素中性子捕捉療法 / ナノ製剤 / ホウ素製剤 / がん光線力学療法 / 六方晶窒化ホウ素 / 光増感剤
Outline of Final Research Achievements

In the cancer therapy by boron neutron capture therapy (BNCT), we need to establish efficient and selective delivery of boron-based drug to tumor. The cancer treatment by BNCT reported so far is not so efficient because of low dispersibility and/or low selectivity. In our research, we successfully prepared boron-containing nanoparticles (B-NP) functionalized with polyglycerol; (PG), characterized structure of the resulting B-NP-PG, and found its high dispersibility. We then injected B-NP-PG to cancered mice, irradiated neutron, and monitored the tumor size for a month. We saw the clear inhibition of the tumor growth rate.

Academic Significance and Societal Importance of the Research Achievements

BNCT において、中性子は人体に取ってほとんど無害であり、また、ホウ素が崩壊して生成するα線やリチウム原子の飛程は、数十μmであり、腫瘍近傍の健全な細胞を殺傷することはない。したがって、今回、B-NP-PGを用いて得られた結果は、副作用のない、非侵襲的ながんの治療法としての BNCT のより効率的な治療に繋がる可能性があり、学術的のみならず、社会的にも大きな意義があると考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Products Report
  • Research Products

    (50 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (15 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 15 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (30 results) (of which Int'l Joint Research: 25 results,  Invited: 7 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] 蘇州大学(中国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Organic chemistry for nanodiamond: Controlled functionalization, quantitative characterization and structure-property relationships2022

    • Author(s)
      Yajuan Zou, Masahiro Nishikawa and Naoki Komatsu
    • Journal Title

      Carbon Reports

      Volume: 1 Issue: 2 Pages: 70-78

    • DOI

      10.7209/carbon.010204

    • ISSN
      2436-5831
    • Year and Date
      2022-06-01
    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extraction of carbon nanotubes with porphyrin- and pyrene-based nanotweezers and nanocalipers: Insight from the association constants2020

    • Author(s)
      A. Lopez Moreno,* Y. Jiang, G. Cheng, N. Komatsu
    • Journal Title

      J. Porphyrins Phthalocyanines

      Volume: 24 Issue: 01n03 Pages: 314-319

    • DOI

      10.1142/s1088424619501086

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative investigation of the interaction between proteins and charged functional groups on the polyglycerol-grafted nanodiamond surface2020

    • Author(s)
      Yajuan Zou,Naoki Komatsu*
    • Journal Title

      Carbon

      Volume: 164 Pages: 395-401

    • DOI

      10.1016/j.carbon.2020.02.089

    • Related Report
      2019 Annual Research Report Products Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Real-time nanodiamond thermometry probing in vivo thermogenic responses2020

    • Author(s)
      Masazumi Fujiwara, Simo Sun, Alexander Dohms, Yushi Nishimura, Ken Suto, Yuka Takezawa, Keisuke Oshimi, Li Zhao, Nikola Sadzak, Yumi Umehara, Yoshio Teki, Naoki Komatsu, Oliver Benson, Yutaka Shikano, Eriko Kage-Nakadai
    • Journal Title

      Science Advances

      Volume: 6 Issue: 37 Pages: eaba9636

    • DOI

      10.1126/sciadv.aba9636

    • NAID

      120006886567

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020469

    • Related Report
      Products Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Magnetic Mixed Micelles Composed of a Non-Ionic Surfactant and Nitroxide Radicals Containing a D-Glucosamine Unit: Preparation, Stability, and Biomedical Application2019

    • Author(s)
      Nagura Kota、Takemoto Yusa、Yoshino Fumi、Bogdanov Alexey、Chumakova Natalia、Vorobiev Andrey、Imai Hirohiko、Matsuda Tetsuya、Shimono Satoshi、Kato Tatsuhisa、Komatsu Naoki、Tamura Rui
    • Journal Title

      Pharmaceutics

      Volume: 11 Issue: 1 Pages: 42-42

    • DOI

      10.3390/pharmaceutics11010042

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Size-tunable MRI-visible nitroxide-based magnetic mixed micelles: preparation, stability, and theranostic application2019

    • Author(s)
      Nagura Kota、Bogdanov Alexey、Chumakova Natalia、Vorobiev Andrey Kh.、Moronaga Satori、Imai Hirohiko、Matsuda Tetsuya、Noda Yohei、Maeda Tomoki、Koizumi Satoshi、Sakamoto Koichi、Amano Tsukuru、Yoshino Fumi、Kato Tatsuhisa、Komatsu Naoki、Tamura Rui
    • Journal Title

      Nanotechnology

      Volume: 30 Issue: 22 Pages: 224002-224002

    • DOI

      10.1088/1361-6528/ab0627

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near‐Infrared Fluorescence In Vivo Tumor Imaging2019

    • Author(s)
      Yoshino Fumi、Amano Tsukuru、Zou Yajuan、Xu Jian、Kimura Fuminori、Furusho Yoshio、Chano Tokuhiro、Murakami Takashi、Zhao Li、Komatsu Naoki
    • Journal Title

      Small

      Volume: 15 Issue: 48 Pages: 1901930-1901930

    • DOI

      10.1002/smll.201901930

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical Functionalization of Nanodiamonds: Opportunities and Challenges Ahead2019

    • Author(s)
      Giacomo Reina, Li Zhao,Alberto Bianco,* and Naoki Komatsu*
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 58 Issue: 50 Pages: 17918-17929

    • DOI

      10.1002/anie.201905997

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property2019

    • Author(s)
      Gang Liu, Ping Zhao, Neng Liu, Fumi Yoshino, Hongmei Qin, Yajuan Zou, Shengwei Shi, Tsukuru Amano, Jose R Aguilar Cosme, Yasunobu Nagano, Hitoshi Tamiaki and Naoki Komatsu
    • Journal Title

      2D Materials

      Volume: 6 Issue: 4 Pages: 045035-045035

    • DOI

      10.1088/2053-1583/ab377b

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Size-controlled MoS2 nanosheet through ball milling exfoliation: parameter optimization, structural characterization and electrocatalytic application2019

    • Author(s)
      Ahmad Tayyebi, Naoko Ogino, Takuya Hayashi, Naoki Komatsu*
    • Journal Title

      Nanotechnology

      Volume: 31 Issue: 7 Pages: 075704-075704

    • DOI

      10.1088/1361-6528/ab5077

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dendritic cell-mediated delivery of doxorubicin-polyglycerol-nanodiamond composites elicits enhanced anti-cancer immune response in glioblastoma2018

    • Author(s)
      T.-F. Li, K. Li, Q. Zhang, C. Wang, Y. Yue, Z. Chen, S.-J. Yuan, X. Liu, Y. Wen, M. Han, N. Komatsu, Y.-H. Xu, L. Zhao,* X. Chen*
    • Journal Title

      Biomaterials

      Volume: 181 Pages: 35-52

    • DOI

      10.1016/j.biomaterials.2018.07.035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Monocyte-mediated chemotherapy drug delivery in glioblastoma2018

    • Author(s)
      C. Wang, K. Li, T.-F. Li, Z. Chen, Y. Wen, X. Liu, X. Jia, Y. Zhang, Y.-H. Xu, M. Han, N. Komatsu, L. Zhao,* X. Chen*
    • Journal Title

      Nanomedicine

      Volume: 13 Issue: 2 Pages: 157-178

    • DOI

      10.2217/nnm-2017-0266

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cationic Polyarginine Conjugated Mesoporous Bioactive Glass Nanoparticles with Polyglycerol Coating for Efficient DNA Delivery2017

    • Author(s)
      L. Zhao, J. Ye, Q. Liang, M. Xu, N. Komatsu, G. Yuan, Q. Zhang, W. Gao, X. Chen
    • Journal Title

      J. Biomed. Nanotechnol.

      Volume: 13 Issue: 3 Pages: 280-289

    • DOI

      10.1166/jbn.2017.2350

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Preparationo of Rubst Metal-Free Magnetic Nanoemulsiions Encapsulating Low-Molecular-Weight Nitoxide Radicals and Hydrophobic Drugs Directed Toward MRI-Visible Targeted Delivery.2017

    • Author(s)
      Nagura, K., Takemoto, Y., Moronaga, S., Uchida, Y., Shimono, S., Shiino, A., Tanigaki, K., Amano, T., Yoshino, F., Noda, Y., Koizumi, S., Komatsu, N., Kato, T., Yamauchi, J., Tamura, R.
    • Journal Title

      Chemisty A European Journal

      Volume: 23 Issue: 62 Pages: 15713-15720

    • DOI

      10.1002/chem.201702785

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment2017

    • Author(s)
      T.-F. Li, K. Li, C. Wang, X. Liu, Y. Wen, Y.-H. Xu, Q. Zhang, Q.-Y. Zhao, M. Shao, Y.-Z. Li, M. Han, N. Komatsu, L. Zhao,* X. Chen,*
    • Journal Title

      J. Control. Release

      Volume: 268 Pages: 128-146

    • DOI

      10.1016/j.jconrel.2017.10.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Diamond and Micelle: Hard and Soft Materials for Nanomedicine2019

    • Author(s)
      Naoki Komatsu
    • Organizer
      EMRS Fall Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polyglycerol grafted nanoparticles improve stealth effect by resisting protein corona formation: A comparison study to PEG2019

    • Author(s)
      Yajuan Zou, Naoki Komatsu
    • Organizer
      EMRS Fall Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation and Characterization of Nitroxide-Based Magnetic Nanoemulsions Directed toward MRI-Visible Targeted Delivery System2019

    • Author(s)
      Kota Nagura, Naoki Komatsu, Rui Tamura
    • Organizer
      EMRS Fall Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An efficient and scalable production of 2D material dispersions using hexahydroxytriphenylene as a versatile exfoliant2019

    • Author(s)
      Gang Liu, Naoki Komatsu
    • Organizer
      EMRS Fall Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Readily Available Stock Solid of MoS2 and WS2 Nanosheets through Solid-Phase Exfoliation by Ball Milling2019

    • Author(s)
      Gang Liu, Naoki Komatsu
    • Organizer
      EMRS Fall Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Case Study for Nanoparticles on Nanodiamond: Facile Preparation of Nanodiamond-iron oxide Nanohybrid2019

    • Author(s)
      Ahmad Tayyebi, Naoki Komatsu
    • Organizer
      EMRS Fall Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative evaluation of polymer density and net charge effects on nanodiamond surface toward protein affinity2019

    • Author(s)
      Yajuan Zou, Naoki Komatsu
    • Organizer
      EMRS Fall Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polyglycerol-grafted nanoparticles confer stealth effect by resisting protein corona formation: A comparison study to PEG2019

    • Author(s)
      Yajuan Zou, Naoki Komatsu
    • Organizer
      FNTG バイオシンポ
    • Related Report
      2019 Annual Research Report
  • [Presentation] Supramolecular nanoscience of 1D and 2D nanomaterials with porphyrinoids2019

    • Author(s)
      Naoki Komatsu
    • Organizer
      International Workshop on Supramolecular Nanoscience of Chemically Programmed Pigments
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MRI-Visible Supramolecular Nanomicelles Containing Nitroxide Radicals: Preparation, Stability and Structural Elucidation2019

    • Author(s)
      Kota Nagura, Rui Tamura and Naoki Komatsu
    • Organizer
      International Workshop on Supramolecular Nanoscience of Chemically Programmed Pigments
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Platinum on diamond: A promising prodrug conjugated with polyglycerol, targeting peptide and anticancer drug2019

    • Author(s)
      Naoki Komatsu
    • Organizer
      EMRS Spring Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantitative evaluation of polymer density and net charge effects on nanodiamond surface toward protein affinity2019

    • Author(s)
      Yajuan Zou, Naoki Komatsu
    • Organizer
      EMRS Spring Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polyglycerol grafted nanoparticles improve stealth effect by resisting protein corona formation: A comparison study to polyethylene glycol2019

    • Author(s)
      Yajuan Zou, Naoki Komatsu
    • Organizer
      EMRS Spring Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation and Characterization of Nitroxide-Based Magnetic Nanoemulsions Directed toward MRI-Visible Targeted Delivery System2019

    • Author(s)
      Kota Nagura, Satoshi Shimono, Tsukuru Amano, Fumi Yoshino, Tatsuhisa Kato, Naoki Komatsu, Rui Tamura
    • Organizer
      EMRS Spring Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A One-Pot Fabrication of Chlorin e6-loaded MoS2 Nanosheet and Its Application to Cancer Phototherapy2019

    • Author(s)
      Gang Liu, Qin Hongmei, Tsukuru Amano, Fumi Yoshino, Naoki Komatsu
    • Organizer
      EMRS Spring Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An efficient and scalable production of 2D material dispersions using hexahydroxytriphenylene as a versatile exfoliant2019

    • Author(s)
      Gang Liu, Naoki Komatsu
    • Organizer
      EMRS Spring Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Readily Available Stock Solid of MoS2 and WS2 Nanosheets through Solid-Phase Exfoliation by Ball Milling2019

    • Author(s)
      Gang Liu, Naoki Komatsu
    • Organizer
      EMRS Spring Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Covalent and Noncovalent Chemistry for Nanocarbons: Biomedical Application and Structural Separation2019

    • Author(s)
      Naoki Komatsu
    • Organizer
      WILEY-Yellow Crane Tower Summit on Advanced Nanomaterials
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Application of polyglycerol-functionalized nanodiamond to cancer therapy,2018

    • Author(s)
      Kenta Takayasu, Tsukuru Amano, Fumi Yoshino, Naoki Komatsu
    • Organizer
      Europeun Materials Research Society Spring Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biomedical Applications of Hexagonal Boron Nitride2018

    • Author(s)
      Kyouhei Maruyama, Naoki Komatsu
    • Organizer
      Europeun Materials Research Society Spring Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of Organic Chemistry to Nanocarbon Materials: From Separation to Biomedical Applications2018

    • Author(s)
      Naoki Komatsu
    • Organizer
      2nd Dijon/Nanjing Symposium on Fuctional Macrocyclic Molecules
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A One-Pot Fabrication of Chlorin e6-loaded MoS2 Nanosheet and Its Application to Photothermal and Photodynamic Combination Cancer Treatment2018

    • Author(s)
      Naoki Komatsu, Gang Liu, Hongmei Qin, Tsukuru Amano, Fumi Yoshino
    • Organizer
      NT18
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An efficient and scalable production of 2D material dispersions using hexahydroxytriphenylene as a versatile exfoliant and dispersant2018

    • Author(s)
      Naoki Komatsu,, Gang Liu
    • Organizer
      NT18
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exfoliation of 2D nanosheets and their biomedical applications2018

    • Author(s)
      Naoki Komatsu
    • Organizer
      European Advanced Materials Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Non-covalent functionalization of carbon nanotubes for their separation2018

    • Author(s)
      Naoki Komatsu
    • Organizer
      European Advanced Materials Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The influence of nanodiamond size and surface functionality on protein corona formation and subsequent macrophage cellular uptake2018

    • Author(s)
      Yajuan Zou, Naoki Komatsu
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stable Aqueous Dispersion of Graphene-Based Composite through Direct Graphite Exfoliation with a Photosensitizer and Its Application to Cancer Phototherapy2018

    • Author(s)
      G. Liu, N. Komatsu
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Direct fabrication of the graphene-based composite for cancer phototherapy through graphite exfoliation with a photosensitizer2017

    • Author(s)
      N. Komatsu, G. Liu, T. Amano
    • Organizer
      28th International Conference on Diamond and Carbon Materials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 六方晶窒化ホウ素ナノシートの化学修飾と生物医療応用2017

    • Author(s)
      丸山恭平、小松直樹
    • Organizer
      第7回 ナノカーボンバイオシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct fabrication of the graphene-based composite for cancer phototherapy through graphite exfoliation with a photosensitizer2017

    • Author(s)
      小松直樹,Liu Gang,天野創
    • Organizer
      第44回炭素材料学会年会
    • Related Report
      2017 Annual Research Report
  • [Book] Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy2018

    • Author(s)
      N. Komatsu
    • Total Pages
      22
    • Publisher
      Wiley
    • ISBN
      9781119373452
    • Related Report
      2018 Annual Research Report
  • [Remarks] 京都大学大学院人間・環境学研究科小松研究室

    • URL

      http://www.komatsu.h.kyoto-u.ac.jp/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] Komatsu Laboratory, Kyoto University

    • URL

      http://www.komatsu.h.kyoto-u.ac.jp/en/

    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 修飾炭化ホウ素粒子及びそれを含む中性子捕捉療法用薬剤2021

    • Inventor(s)
      小松直樹、鈴木実
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-122588
    • Filing Date
      2021
    • Related Report
      Products Report
    • Overseas

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Published: 2017-04-28   Modified: 2023-03-30  

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