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Active control of 3D arrangement on mesoscopic particles and their application to biological imaging

Research Project

Project/Area Number 17H02744
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials engineering
Research InstitutionTohoku University

Principal Investigator

Nagao Daisuke  東北大学, 工学研究科, 教授 (50374963)

Co-Investigator(Kenkyū-buntansha) 梅津 光央  東北大学, 工学研究科, 教授 (70333846)
石井 治之  山口大学, 大学院創成科学研究科, 准教授(テニュアトラック) (80565820)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywordsナノ材料 / 中空粒子 / 集積体 / センシング / 異方性粒子
Outline of Final Research Achievements

The objective of the present work is development of nanomaterials usable for imaging specific parts of organisms. Several types of monodisperse yolk/shell particles, which are composed of a movable inner core and outer silica shell, were synthesized to prepare colloidal crystals applicable to the imaging. The yolk/shell structure is found to allow inner metal cores to exhibit intrinsic optical properties and also show the Raman signals even when the yolk/shell particles are assembled in a limited space.

Academic Significance and Societal Importance of the Research Achievements

金属ナノ粒子は、比表面積が大きく容易に凝集するため、金属ナノ粒子本来の特性を機能性材料として活かせない問題があった。本研究では粒子集積させた状態でその本来の特性を材料の機能として活かせる構造としてYolk/Shell型コロイド結晶に着目した。本構造を利用すれば、集積状態でも本来の特性を大きく損なうなく、粒子高密度化によるラマンシグナル等の増強効果が期待できることを示した点に学術的な意義がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (28 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (18 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] ユトレヒト大学(オランダ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Compartmentalization of gold nanoparticle clusters in hollow silica spheres and their assembly induced by an external electric field2020

    • Author(s)
      Kanako Watanabe, Tom A. J. Welling, Sina Sadighikia, Haruyuki Ishii, Arnout Imhof, Marijn A. van Huis, Alfons van Blaaderen, Daisuke Nagao
    • Journal Title

      Journal of Colloid and Interface Science

      Volume: 566(15) Pages: 202-210

    • DOI

      10.1016/j.jcis.2020.01.094

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional periodic structures of gold nanoclusters in the interstices of sub-100 nm polymer particles toward surface-enhanced Raman scattering2019

    • Author(s)
      Ayumi Yahata, Haruyuki Ishii, Kosuke Nakamura, Kanako Watanabe, Daisuke Nagao
    • Journal Title

      Advanced Powder Technology

      Volume: 30(12) Issue: 12 Pages: 2957-2963

    • DOI

      10.1016/j.apt.2019.09.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization on magnetophoretic velocity of the cluster of submicron-sized composite particles applicable to magnetic separation and purification2019

    • Author(s)
      Natsuki Kohama, Chika Suwabe, Haruyuki Ishii, Kumiko Hayashi, Daisuke Nagao
    • Journal Title

      Colloids and Surfaces A: Physicochemical and Engineering Aspects

      Volume: 568 Pages: 141-146

    • DOI

      10.1016/j.colsurfa.2019.02.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasmonic properties of gold nanoparticle clusters formed via applying AC electric field2018

    • Author(s)
      Kanako Watanabe, Eri Tanaka, Haruyuki Ishii and Daisuke Nagao
    • Journal Title

      Soft Matter

      Volume: 印刷中 Issue: 17 Pages: 3372-3377

    • DOI

      10.1039/c8sm00097b

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uniform formation of mesoporous silica shell on micron-sized cores in the presence of hydrocarbon used as a swelling agent2018

    • Author(s)
      Haruyuki Ishii, Mitsunobu Nara, Yuri Hashimoto, Arata Kanno, Shunho Ishikawa, Daisuke Nagao, Mikio Konno
    • Journal Title

      Journal of Sol-Gel Science and Technology

      Volume: 85 Issue: 3 Pages: 539-545

    • DOI

      10.1007/s10971-018-4589-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 細胞内観察へ向けた蛍光磁性複合粒子の分散・凝集制御2020

    • Author(s)
      亀田涼太、新井しおり、渡部花奈子、林久美子、長尾大輔
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 金コア-シリカシェル粒子の単分散な球状集積体作製プロセスの検討2020

    • Author(s)
      持明佳祐、渡部花奈子、長尾大輔
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 蛍光シリカナノ粒子を利用したフレキシブルな蛍光ナノコンポジット膜の作製2020

    • Author(s)
      末田良樹、佐藤昌紀、渡部花奈子、長尾大輔
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 金ナノ粒子が3次元に非最密集積した構造体の作製2020

    • Author(s)
      長谷川将史、渡部花奈子、長尾大輔
    • Organizer
      マテリアル・ファブリケーション・デザインセミナー
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of silica encapsulation on plasmon characteristics of gold nanotriangle2019

    • Author(s)
      K. Nakamura, K. Watanabe, D. Nagao
    • Organizer
      OKINAWA COLLOIDS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 金ナノトライアングルのシリカ被覆プロセスとプラズモン特性に関する研究2019

    • Author(s)
      中村幸佑、黒田昂太郎、渡部花奈子、長尾大輔
    • Organizer
      第21回先端研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シリカカプセル化金ナノトライアングルの作製とそのプラズモン特性2019

    • Author(s)
      中村幸佑、黒田昂太郎、渡部花奈子、石井治之、長尾大輔
    • Organizer
      化学工学会第84年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 単分散な微粒子を集めて作れる新材料2019

    • Author(s)
      長尾大輔
    • Organizer
      マテリアル・ファブリケーション・デザインセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 蛍光シリカ粒子を充填したフレキシブル蛍光ナノコンポジット膜の作製2019

    • Author(s)
      前田悠希、金澤惇、石井治之、長尾大輔
    • Organizer
      第21回化学工学会学生発表会【東京大会】
    • Related Report
      2018 Annual Research Report
  • [Presentation] 触媒担体粒子に向けた単分散磁性複合粒子の特性に及ぼす粒径の影響2018

    • Author(s)
      小濵奈月、石井治之、今野幹男、長尾大輔
    • Organizer
      化学工学会第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 金-ポリマー二成分ナノ粒子配列体によるプラズモン特性の制御2018

    • Author(s)
      八幡あゆみ、石井治之、長尾大輔
    • Organizer
      化学工学会第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis of fluorescently-labelled magnetic composite particles using double electrostatic heterocoagulation2018

    • Author(s)
      S. Arai, N. Kohama, H. Ishii, D. Nagao
    • Organizer
      32nd Conference of the European Colloid and Interface Society (ECIS)2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヘテロ凝集法を用いた蛍光磁性複合粒子の合成2018

    • Author(s)
      新井しおり、小濵奈月、石井治之、長尾大輔
    • Organizer
      第20回先端研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Preparation of magnetic composite particles toward precise separation of target biomolecules2018

    • Author(s)
      N. Kohama, K. Watanabe, H. Ishii, M. Konno, D. Nagao
    • Organizer
      16th Conference of the International Association of Colloid and Interface Scientists
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fabrication of Ordered Structure Incorporating Gold Nanoparticles for Highly Sensitive Detection of Chemical Components2018

    • Author(s)
      A. Yahata, H. Ishii, D. Nagao
    • Organizer
      The 6th Asian Symposium on Emulsion Polymerization and Functional Polymeric Microspheres
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微量化学成分検出に向けた金ナノ粒子内包周期構造体の作製2017

    • Author(s)
      八幡あゆみ、石井治之、長尾大輔
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高感度分子センサーへの応用に向けた金ナノ粒子集積システムの提案2017

    • Author(s)
      渡部花奈子、石井治之、長尾大輔
    • Organizer
      化学工学会第49回秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A new method for controlling the clustering of nanoparticles in their assembly2017

    • Author(s)
      K. Watanabe, H. Ishii, D. Nagao
    • Organizer
      UK Colloids 2017 : An International Colloids and Interface Science Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 高分子微粒子ハンドブック「Yolk/Shell 構造粒子」2017

    • Author(s)
      渡部花奈子、 長尾大輔
    • Total Pages
      10
    • Publisher
      株式会社シーエムシー出版
    • Related Report
      2017 Annual Research Report
  • [Remarks] 長尾研究室HP

    • URL

      https://www.che.tohoku.ac.jp/~mpe/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東北大学大学院工学研究科 化学工学専攻 長尾研究室HP

    • URL

      https://www.che.tohoku.ac.jp/~mpe/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学大学院工学研究科 化学工学専攻 長尾研究室HP

    • URL

      http://www.che.tohoku.ac.jp/~mpe/index.html

    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2023-12-25  

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