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Fabrication of sequential infrared spectroscopy incorporating micro reactor -development in life science and materials science-

Research Project

Project/Area Number 17H02756
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nano/Microsystems
Research InstitutionTokyo University of Science

Principal Investigator

ISHIGURO TAKASHI  東京理科大学, 基礎工学部材料工学科, 教授 (10183162)

Co-Investigator(Kenkyū-buntansha) 山本 貴博  東京理科大学, 理学部, 助教 (30408695)
谷口 淳  東京理科大学, 基礎工学部電子応用工学科, 教授 (40318225)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Keywords赤外顕微分光 / FT-IR / ATP / マイクロリアクタ― / 水熱反応 / マイクロリアクター / 赤外線顕微鏡 / 光触媒 / 細胞 / 光合成 / 二酸化炭素 / 赤外顕微鏡 / マイクロ・ナノデバイス / 生物・生体工学 / 触媒・化学プロセス / ナノ材料
Outline of Final Research Achievements

Many of the chemical reactions we note occur in aqueous solutions. Infrared spectroscopy is excellent for detecting chemical species, but it is difficult to perform quantitative measurement because of strong absorption of water itself. Furthermore, it is inevitable that the sensitivity of the infrared spectrometer changes with the time difference between the reference light and the sample transmitted light measurement. Therefore, in this study, we constructed a transmission infrared spectroscopy system incorporating a microreactor that can simultaneously measure reference light and sample transmitted light in different regions. As a result, stable measurement of chemical species in aqueous solution was realized.

Academic Significance and Societal Importance of the Research Achievements

水溶液中の化学種は、イオンや水素結合状態にあり化学反応の進行を定量的に評価する手段が望まれている.赤外分光法は化学種同定に優れているが、参照光と試料透過光を異なる時刻に計測し、吸光度を算出するのが一般的である.赤外線を水に透過させるために光路長は短くなければならず、加えて無視できない装置感度の時間的変動のため、化学反応の長時間定量評価は困難である.そこで2流路を持つ1μm程度の光路長のマイクロリアクタを作製し、リニアアレーによる同時計測を実現した.これにより長時間の安定的透過赤外分光評価が可能となった.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (23 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (16 results) (of which Int'l Joint Research: 8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Scanning Transmission Electron Microscopy Characterization of Nanostructured Palladium Film Formed by Dealloying with Citric Acid from Al–N–Pd Mother Alloy Film2019

    • Author(s)
      Takuji Ube, Akizumi Kawamoto, Takashi Ishiguro
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 60 Issue: 4 Pages: 525-530

    • DOI

      10.2320/matertrans.MBW201808

    • NAID

      130007618547

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2019-04-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reaction Acceleration of Nanoporous High-Purity Pd Film Formation by Dealloying of Al-Pd-N Film in pH-Controlled EDTA Solution2019

    • Author(s)
      Tomoya Nishi, Syuya Hasegawa, Takuji Ube, and Takashi Ishiguro
    • Journal Title

      MRS Advances

      Volume: 5 Issue: 11 Pages: 531-538

    • DOI

      10.1557/adv.2020.59

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication and Morphological Control of a Palladium Film with a Three-Dimensional Nano-Network Structure as a Hydrogen Gas Sensing Material using Organic Acid Chelation2019

    • Author(s)
      Ube Takuji、Kawamoto Akizumi、Nishi Tomoya、Ishiguro Takashi
    • Journal Title

      MRS Advances

      Volume: - Issue: 5-6 Pages: 1-6

    • DOI

      10.1557/adv.2019.82

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hybrid classical/quantum simulation for infrared spectroscopy of water2018

    • Author(s)
      Yuki Maekawa, Kenji Sasaoka, Takuji Ube, Takashi Ishiguro, Takahiro Yamamoto
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 5 Pages: 058005-058005

    • DOI

      10.7567/jjap.57.058005

    • NAID

      210000149072

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transmission infrared micro-spectroscopic study of lactic acid production in cultured cells2018

    • Author(s)
      Ube Takuji、Yamamoto Kanako、Ishiguro Takashi
    • Journal Title

      Vibrational Spectroscopy

      Volume: 98 Pages: 8-14

    • DOI

      10.1016/j.vibspec.2018.06.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <i>In situ</i> Measurement of the pH-dependent Transmission Infrared Spectra of Aqueous Lactic Acid Solutions2017

    • Author(s)
      Takuji Ube, Yasuko Yoneyama, and Takashi Ishiguro
    • Journal Title

      Analytical Sciences

      Volume: 33 Issue: 12 Pages: 1395-1400

    • DOI

      10.2116/analsci.33.1395

    • NAID

      130006248792

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Formation of high purity nanoporous Pd film by dealloying using pH controlled organic acid chelate solution2019

    • Author(s)
      T. Nishi, A. Kawamoto, T. Ube, T. Ishiguro
    • Organizer
      6th Nano Today Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reaction Acceleration of Nanoporous High Purity Pd Film Formation by Dealloying of Al-Pd-N Film in pH-Controlled EDTA Solution2019

    • Author(s)
      Tomoya Nishi, Syuya Hasegawa, Takuji Ube, and Takashi Ishiguro
    • Organizer
      2019 MRS Fall Meetings & Exhibit
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 水溶液中ラジカルの赤外分光2019

    • Author(s)
      石黒孝、箕浦健人、宇部卓司
    • Organizer
      東京理科大学研究推進機構総合研究院 2019年度イメージングフロンティアセンターシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] アミノアルコールによるヘモグロビン脱色機構2019

    • Author(s)
      友清克哉、早川周作、宇部卓司、石黒孝
    • Organizer
      東京理科大学研究推進機構総合研究院 2019年度イメージングフロンティアセンターシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 透過赤外分光法におけるマイクロ流路デバイスの作製と吸光度逐次評価2019

    • Author(s)
      黒川雄太、後藤拓文、ショウカイラク、宇部卓司、石黒孝
    • Organizer
      東京理科大学研究推進機構総合研究院 2019年度イメージングフロンティアセンターシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 光触媒を用いた水中二酸化炭素還元反応の赤外分光評価2019

    • Author(s)
      小松駿樹、荒木伸太郎、宇部卓司、石黒孝
    • Organizer
      東京理科大学研究推進機構総合研究院 アグリ・バイオ工学研究部門 公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 入射光・試料透過光の同時計測・透過赤外分光顕微鏡システムの開発2019

    • Author(s)
      黒川雄太、石黒孝、宇部卓司、谷口潤、鐘愷楽
    • Organizer
      2019年日本金属学会春期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Sequential Transmission Infrared Spectroscopic Microscope Incorporating Microreactor2018

    • Author(s)
      Takashi Ishiguro, Takuji Ube, and Yuta Kurokawa
    • Organizer
      19th Internataional Microscopy Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] pH Dependence of Transmission Infrared Spectrum of ATP Aqueous Solution2017

    • Author(s)
      Anna Ohwada, Takuji Ube, and Takashi Ishiguro
    • Organizer
      Europian Conference on the Spectroscopy of Biological Molecules 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acceleration of dealloying reaction of Pd-Al-N films using pH controlled citric acid chelate solution and formation of nanoporous Pd-Al films2017

    • Author(s)
      TakujUbe, Akizumi Kawamoto, Takashi Harumoto, and Takashi Ishiguro
    • Organizer
      5th Nano Today Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 有機酸を用いた脱合金反応による3Dナノポーラスパラジウム膜の形態制御と特性評価2017

    • Author(s)
      宇部卓司、河本明純、石黒孝
    • Organizer
      2018年日本金属学会春期大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クエン酸を用いたPd-Al-N膜の脱合金反応によるナノポーラス膜形態制御2017

    • Author(s)
      河本明純、宇部卓司、石黒孝
    • Organizer
      2017年日本金属学会秋期大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of in situ transmission infrared microscopy system and its application to observation of living cell2017

    • Author(s)
      Takashi Ishiguro, T. Ube, and Y. Yoneyama
    • Organizer
      Microscopy Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transmission FT-IR spectroscopy of DPPC membrane modified by using ScaleA22017

    • Author(s)
      Katsura Masukawa, Takuji Ube, and Takashi Ishiguro
    • Organizer
      International Symposium on Imaging Frontier 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of transmission infrared spectroscopy to living cells and biomaterials evaluation in aqueous solution2017

    • Author(s)
      Takuji Ube and Takashi Ishiguro
    • Organizer
      International Symposium on Imaging Frontier 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 透過赤外分光顕微鏡による細胞代謝その場観察2017

    • Author(s)
      宇部卓司、米山靖子、石黒 孝
    • Organizer
      日本顕微鏡学会 第73回学術講演会
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 分光測定装置、及び分光測定方法2019

    • Inventor(s)
      石黒孝
    • Industrial Property Rights Holder
      石黒孝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2022-12-28  

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