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Microscopic Chemical State Analysis Based on Chemical Shift in Soft X-ray Inner-shell Excitation

Research Project

Project/Area Number 17H03013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical chemistry
Research InstitutionHigh Energy Accelerator Research Organization (2018-2019)
Institute for Molecular Science (2017)

Principal Investigator

KOSUGI Nobuhiro  大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 所長 (20153546)

Co-Investigator(Kenkyū-buntansha) 大東 琢治  分子科学研究所, 極端紫外光研究施設, 助教 (50375169)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords量子ビーム / 内殻励起 / X線顕微分光 / その場観測 / マイクロ流路 / 薬物伝達 / X線顕微分光
Outline of Final Research Achievements

Our theoretical approaches have predicted small chemical shifts in molecular inner-shell excitations at chemically different sites. Based on this idea, we have developed and improved nanoscale and microscale soft X-ray absorption spectromicroscopic techniques with in situ sample cells and successfully applied them to binary liquid reactions in microfluidic devices and to transdermal drug delivery systems, to get chemical shift images by less than 10 meV for chemical state mappings of reactive sites and inhomogeneous molecular distributions.

Academic Significance and Societal Importance of the Research Achievements

独自開発した軟X線吸収試料セルを組み込んだナノスケール、マイクロスケールの顕微鏡の集光系を、対象となる試料の状態に応じて、改良・最適化することに成功したことは、国際的に独創的な技術革新となっている。新しい反応系を設計できるマイクロ流路や効率的な塗り薬開発に重要な経皮薬物輸送の研究にこれらの装置を応用し、特定分子の化学的環境のナノスケール及びマイクロスケールのイメージングが実現したことは、放射光顕微技術の発展に伴って研究対象が均一系から不均一系に拡大している放射光軟X線分野における学術研究の新しい展開につながるものとなっている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (51 results)

All 2020 2019 2018 2017 2015 Other

All Int'l Joint Research (14 results) Journal Article (17 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 17 results,  Open Access: 9 results) Presentation (19 results) (of which Int'l Joint Research: 11 results,  Invited: 5 results) Remarks (1 results)

  • [Int'l Joint Research] ベルリン自由大学(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] SOLEIL放射光研究所(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] オウル大学(フィンランド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 台湾淡江大学/国立放射光研究所NSRRC(台湾)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ベルリン自由大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] オウル大学(フィンランド)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 台湾淡江大学/国立放射光研究所NSRRC(台湾)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] SOLEIL放射光研究所(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ベルリン自由大学/ヘルムホルツ協会ベルリン研究センター(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] SOLEIL放射光研究施設(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] オウル大学(フィンランド)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ローレンス・バークレー国立研究所(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 台湾放射光研究センター/淡江大学(台湾)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Soft X-ray Absorption Spectroscopy of Liquids for Understanding Chemical Processes in Solution2020

    • Author(s)
      NAGASAKA Masanari, YUZAWA Hayato, KOSUGI Nobuhiro
    • Journal Title

      Analytical Sciences

      Volume: 36 Issue: 1 Pages: 95-105

    • DOI

      10.2116/analsci.19R005

    • NAID

      130007783842

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2020-01-10
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microheterogeneity in Aqueous Acetonitrile Solution Probed by Soft X-ray Absorption Spectroscopy2020

    • Author(s)
      Nagasaka Masanari, Yuzawa Hayato, Kosugi Nobuhiro
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 124 Issue: 7 Pages: 1259-1265

    • DOI

      10.1021/acs.jpcb.0c00551

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Fe2O3 coating on ZnO nanowires in photoelectrochemical water splitting: A synchrotron x-ray spectroscopic and spectromicroscopic investigation2020

    • Author(s)
      Lu Y.R., Wang Y.F., Chang H.W., Huang Y.C., Chen J.L., Chen C.L., Lin Y.C., Lin Y.G., Pong Way-Faung, Ohigashi Takuji, Kosugi Nobuhiro, Kuo C.H., Chou W.C., Dong C.L.
    • Journal Title

      Solar Energy Materials and Solar Cells

      Volume: 209 Pages: 110469-110469

    • DOI

      10.1016/j.solmat.2020.110469

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a sample holder for synchrotron radiation-based computed tomography and diffraction analysis of extraterrestrial materials2020

    • Author(s)
      Uesugi Masayuki、Hirahara Kaori、Uesugi Kentaro、Takeuchi Akihisa、Karouji Yuzuru、Shirai Naoki、Ito Motoo、Tomioka Naotaka、Ohigashi Takuji、Yamaguchi Akira、Imae Naoya、Yada Toru、Abe Masanao
    • Journal Title

      Review of Scientific Instruments

      Volume: 91 Issue: 3 Pages: 035107-035107

    • DOI

      10.1063/1.5122672

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laminar flow in microfluidics investigated by spatially-resolved soft X-ray absorption and infrared spectroscopy2019

    • Author(s)
      Nagasaka Masanari, Yuzawa Hayato, Takada Noriko, Aoyama Masaki, Ruehl Eckart, Kosugi Nobuhiro
    • Journal Title

      The Journal of Chemical Physics

      Volume: 151 Issue: 11

    • DOI

      10.1063/1.5115191

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative Distribution of DNA, RNA, Histone and Proteins Other than Histone in Mammalian Cells, Nuclei and a Chromosome at High Resolution Observed by Scanning Transmission Soft X-Ray Microscopy (STXM)2019

    • Author(s)
      K. Shinohara, S. Tone, T. Ejima, T. Ohigashi, A. Ito
    • Journal Title

      Cells

      Volume: 8 Issue: 2 Pages: 164-164

    • DOI

      10.3390/cells8020164

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hybrid films of cellulose nanofibrils, chitosan and nanosilica?Structural, thermal, optical, and mechanical properties2019

    • Author(s)
      Ismail Mostafa Y., Patanen Minna, Sirvioe Juho Antti, Visanko Miikka, Ohigashi Takuji, Kosugi Nobuhiro, Huttula Marko, Liimatainen Henrikki
    • Journal Title

      Carbohydrate Polymers

      Volume: 218 Pages: 87-94

    • DOI

      10.1016/j.carbpol.2019.04.065

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intermolecular Interactions of Pyridine in Liquid Phase and Aqueous Solution Studied by Soft X-ray Absorption Spectroscopy2018

    • Author(s)
      M. Nagasaka, H. Yuzawa, N. Kosugi
    • Journal Title

      Z. Phys. Chem.

      Volume: 232 Issue: 5-6 Pages: 705-722

    • DOI

      10.1515/zpch-2017-1054

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temperature-Dependent Structural Changes in Liquid Benzene2018

    • Author(s)
      M. Nagasaka, H. Yuzawa, K. Mochizuki, E. Ruehl, N. Kosugi
    • Journal Title

      J. Phys. Chem. Lett.

      Volume: 9 Issue: 19 Pages: 5827-5832

    • DOI

      10.1021/acs.jpclett.8b02615

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Highly Efficient 2D/3D Hybrid Perovskite Solar Cells via Low-Pressure Vapor-Assisted Solution Process2018

    • Author(s)
      M-H. Li, H-H Yeh, U-S. Jeng, C-J. Su, H-W. Shiu, Y-J. Hsu, N. Kosugi, T. Ohigashi, Y-A. Chen, P-S. Shen, P. Chen, T-F. Guo
    • Journal Title

      Advanced Materials

      Volume: 30 Issue: 30 Pages: 1801401-1801401

    • DOI

      10.1002/adma.201801401

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative analysis of mammalian chromosome by scanning transmission soft X-ray microscopy2018

    • Author(s)
      K. Shinohara, T. Ohigashi, S. Tone, M. Kado, A. Ito
    • Journal Title

      Ultramicroscopy,

      Volume: 194 Pages: 1-6

    • DOI

      10.1016/j.ultramic.2018.07.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Origin of Magnetic properties in carbon Implanted ZnO nanowires2018

    • Author(s)
      Y.F. Wang, Y.C. Shao, S.H. Hsieh, Y.K. Chang, P.H. Yeh, H.C. Hsueh, J.W. Chiou, H.T. Wang, S.C. Ray, H.M. Tsai, C.W. Pao, C.H. Chen, H.J. Lin, J.F. Lee, C.T. Wu, J.J. Wu, Y.M. Chang, K. Asokan, K.H. Chae, T. Ohigashi, Y. Takagi, T. Yokoyama, N. Kosugi, W.F. Pong
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1

    • DOI

      10.1038/s41598-018-25948-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reliable absorbance measurement of liquid samples in soft X-ray absorption spectroscopy in transmission mode2018

    • Author(s)
      M. Nagasaka, H. Yuzawa, T. Horigome, N. Kosugi
    • Journal Title

      J. Electron Spectrosc. Relat. Phenom.

      Volume: 224 Pages: 93-99

    • DOI

      10.1016/j.elspec.2017.05.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] orphology control in polymerized high internal phase emulsion templated via macro-RAFT agent composition: Visualizing surface chemistry2018

    • Author(s)
      A. Khodabandeh, R.D. Arrua, B.R. Coad, T. Rodemann, T. Ohigashi, N. Kosugi, S.C. Thickett and E. Hilder
    • Journal Title

      Polymer Chemistry

      Volume: 9 Issue: 2 Pages: 213-220

    • DOI

      10.1039/c7py01770g

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Interaction between Water and Alkali Metal Ions and Its Temperature Dependence Revealed by Oxygen K-Edge X-ray Absorption Spectroscopy2017

    • Author(s)
      M. Nagasaka, H. Yuzawa, N. Kosugi
    • Journal Title

      J. Phys. Chem. B

      Volume: 121 Issue: 48 Pages: 10957-10964

    • DOI

      10.1021/acs.jpcb.7b09789

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of measurement condition for 3-dimensional spectroscopy by scanning transmission X-ray microscopy2017

    • Author(s)
      T. Ohigashi,, Y. Inagaki, A. Ito, K. Shinohara, N. Kosugi
    • Journal Title

      IOP Conf. Series: Journal of Physics: Conf. Series

      Volume: 849 Pages: 012044-012044

    • DOI

      10.1088/1742-6596/849/1/012044

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Local Structure Analysis of Electrochemical Reaction by Soft X-ray Absorption Spectroscopy2015

    • Author(s)
      長坂将成, 小杉信博
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 64 Issue: 3 Pages: 163-172

    • DOI

      10.2116/bunsekikagaku.64.163

    • NAID

      130005060602

    • ISSN
      0525-1931
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 走査型透過X線顕微鏡を用いたリチウムの顕微分析手法2020

    • Author(s)
      長坂将成, 湯沢勇人, 小杉信博
    • Organizer
      第33回日本放射光学会年会・放射光科学合同シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Intermolecular Interactions Revealed by Precise Energy Shift Analysis in Soft X-ray Absorption Spectroscopy for Liquid2019

    • Author(s)
      M. Nagasaka, N. Kosugi
    • Organizer
      The 40th International Conference on Vacuum Ultraviolet and X-ray Physics (VUVX19)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent Status and Developments of a Scanning Transmission X-ray Microscopy Beamline in UVSOR-III Synchrotron2019

    • Author(s)
      T. Ohigashi
    • Organizer
      The 25th NSRRC User’s Meeting and Workshop
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 軟X線吸収分光法によるアセトニトリル水溶液の微小不均一性の解明2019

    • Author(s)
      長坂将成, 湯沢勇人, 小杉信博
    • Organizer
      第22回XAFS討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 3d遷移金属化合物の内殻励起から何がわかるか2019

    • Author(s)
      小杉信博
    • Organizer
      第22回XAFS討論会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 軟X線吸収分光法によるアセトニトリル水溶液の微小不均一性の解明2019

    • Author(s)
      長坂将成, 湯沢勇人, 小杉信博
    • Organizer
      第13回分子科学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 軟X線吸収分光法によるマイクロ流路上の層流の構造解析2019

    • Author(s)
      長坂将成, 湯沢勇人, 高田紀子, 青山正樹, E. Ruehl, 小杉信博
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Microfluidics of Liquid Mixtures Observed by Spatially Resolved Soft X‐ray Absorption Spectroscopy2018

    • Author(s)
      M. Nagasaka, A. A. Vu, H. Yuzawa, N. Takada, M. Aoyama, E. Ruehl, N. Kosugi
    • Organizer
      International Workshop on Trends in Advanced Spectroscopy in Materials Science, TASPEC
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 3-Dimentional Chemical Mapping of an Isolated Cell Nucleus2018

    • Author(s)
      T. Ohigashi, K. Shinohara, S. Tone, H. Yuzawa, A. Ito, N. Kosugi
    • Organizer
      International Workshop on Trends in Advanced Spectroscopy in Materials Science, TASPEC
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Progress in Molecular Inner-shell Spectroscopy2018

    • Author(s)
      N. Kosugi
    • Organizer
      International Workshop on Trends in Advanced Spectroscopy in Materials Science, TASPEC
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] STXM Chemical Mapping of Norway Spruce Knotwood Lignans2018

    • Author(s)
      M. Huttula, M. Patanen, R. Piispanen, T. Ohigashi, N. Kosugi, S. Swaraj, R. Belkhou, A. Pranovich, T. Jyske, P. Kilpelainen, A. Karkonen, R. Korpinen, T. Laakso, S. Valkonen and P. Saranpaa
    • Organizer
      14th International Conference on X-ray Microscopy, XRM2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 3-Dimentional Chemical Structures of an Isolated Cell Nucleus by a Scanning X-ray Transmission Microscope2018

    • Author(s)
      T. Ohigashi, A. Ito, K. Shinohara, S. Tone, Y. Inagaki, H. Yuzawa, N. Kosugi
    • Organizer
      14th International Conference on X-ray Microscopy, XRM2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Probing the Electronic Structure of BiVO4 Coated ZnO Nanodendrite Core- Shell Nanocomposite Using X-ray Spectroscopic and Spatially Resolved Scanning Transmission2018

    • Author(s)
      M.M. Shirolkar, Y.F. Wang, Y.C. Shao, K.H. Chen, H.T. Wang, X.S. Qiu, J.S. Yang, J.J. Wu, J.W. Chiou, T. Ohigashi, N. Kosugi, W.F. Pong
    • Organizer
      14th International Conference on X-ray Microscopy, XRM2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interactions of organic molecules with water in aqueous solutions studied by soft X-ray absorption spectroscopy2018

    • Author(s)
      M. Nagasaka
    • Organizer
      Freigeist Workshop 2018 on Carbon Nanomaterials in Aqueous Environment: From Characterization to Applications
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 軟X線吸収分光法による液体の局所構造解析と溶液反応のオペランド観測2018

    • Author(s)
      長坂将成
    • Organizer
      日本分光学会遠紫外分光部会 第3回講演会「遠/深紫外分光と材料物性」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 走査型透過X線顕微鏡を用いた3次元化学状態マッピング法の開発2018

    • Author(s)
      大東琢治、稲垣裕一、伊藤敦、篠原邦夫、刀祢重信、小杉信博
    • Organizer
      日本放射光学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Advances in Scanning Transmission X-ray Microscopy at UVSOR-III Synchrotron2017

    • Author(s)
      T. Ohigashi, Y. Inagaki, N. Kosugi
    • Organizer
      24th Congress of the International Commission for Optics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Advanced Analyses in Scanning Transmission X-ray Microscopy at UVSOR-III Synchrotron2017

    • Author(s)
      T. Ohigashi, Y. Inagaki, N. Kosugi
    • Organizer
      24th International Congress on X-ray Optics and Microanalysis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] UVSORの走査型透過X線顕微鏡の現状2017

    • Author(s)
      大東琢治、稲垣裕一、小杉信博
    • Organizer
      X線結像光学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Remarks] BL4U STXM Beamline

    • URL

      https://www.uvsor.ims.ac.jp/staff/BL4U/index.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-08-22  

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