Basic Research Study on Drug Delivery System Using Design and Synthesis of Two-Photon Responsive New Chromophore
| Project/Area Number |
17H03022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Abe Manabu 広島大学, 理学研究科, 教授 (30273577)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | ケージド化合物 / 近赤外光 / ２光子励起 / 生物活性物質 / 光解離性保護基 / 近赤外２光子 / ドラッグデリバリー / 生理活性物質 / 2光子励起反応 / 2光子吸収 / クマリン / スチルベン / ２光子吸収 |
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| Outline of Final Research Achievements |
In this study, we designed and synthesized a D-π-D type caged benzoic acid based on a π-expanded coumarin chromophore with a relatively high two-photon absorption cross section (σ2 = 855 GM). Its photoreactivity was investigated. As a result, benzoic acid was obtained in a yield of about 50%, and 4 types of coumarin-derived products were successfully isolated. In addition, we designed a caged benzoic acid with an indene skeleton that can be expected to undergo skeletal changes before and after light irradiation. Its photochemical properties and the generation of benzoic acid by the photodissociation reaction were investigated. As a result, the process of quantitatively releasing benzoic acid with time was confirmed by 1H NMR, and efficient uncaging was achieved.
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| Academic Significance and Societal Importance of the Research Achievements |
生理活性物質が生体内組織の「どの場所」で「どのように」機能するのかを明らかにする研究は，生命現象の解明に直結し，人類が直面している疾患に対する薬剤の開発に貢献でき，豊かな社会の形成とその持続的な発展に寄与する．本研究では，「近赤外領域の２光子を効率よく吸収する新規光解離性保護基(PPG)」を開発し，細胞毒が低い近赤外領域の光を使用可能なPPGの開発は、生体試料の深部において高い解像度での生理活性物質（＝薬剤）の放出を実現する．研究期間内に，ヒトの記憶と学習に関与する神経伝達物質や抗がん作用のある薬剤を特定の場所で人工的に発生させることができる治療システムの構築に寄与する．
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] B(MIDA)-Containing Diborons2017
Author(s)
Hiroto Yoshida, Michinari Seki, Ikuo Kageyuki, Itaru Osaka, Sayaka Hatano, Manabu Abe
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Journal Title
ACS Omega
Volume: 2
Issue: 9
Pages: 5911-5916
DOI
NAID
Related Report
Peer Reviewed / Open Access
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