| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Preparation of water-soluble 2-sulfanylhydroquinone dimer and derivatized it for a bio-imaging material. We succeeded to detect BSA protein as a model study using this derivative and showed it would be a potential photoluminescence compound for this purpose. We also developed selective demethylation reaction for its tetramethyl ether, and achieved one-step preparation of mono-methyl derivative. Its oxidation form, mono-quinone derivative, showed good photolumenscence when exposed to reductive conditions delivered by ascorbic acid, and found that it would be a potential compound serving as a new reagent for detection of reducing agents.
Several derivatives of deltaarene, a new macrocyclic compounds based on a 2-sulfanylhydroquinone dimer, were prepared and estimated their shape and size of the holes. We also examined several reactions towards their derivatization and chemical modification.
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