Development of new functional materials based on hydroquinone dimers
| Project/Area Number |
17H03023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KAMIMURA Akio 山口大学, 大学院創成科学研究科, 教授 (30194971)
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| Co-Investigator(Kenkyū-buntansha) |
川本 拓治 山口大学, 大学院創成科学研究科, 助教 (70756139)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 蛍光材料 / バイオイメージング / 水溶性 / ポリエチレングリコール / 大環状化合物 / ホストゲスト化学 / C3対称性 / アセタール |
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| Outline of Final Research Achievements |
Preparation of water-soluble 2-sulfanylhydroquinone dimer and derivatized it for a bio-imaging material. We succeeded to detect BSA protein as a model study using this derivative and showed it would be a potential photoluminescence compound for this purpose. We also developed selective demethylation reaction for its tetramethyl ether, and achieved one-step preparation of mono-methyl derivative. Its oxidation form, mono-quinone derivative, showed good photolumenscence when exposed to reductive conditions delivered by ascorbic acid, and found that it would be a potential compound serving as a new reagent for detection of reducing agents.
Several derivatives of deltaarene, a new macrocyclic compounds based on a 2-sulfanylhydroquinone dimer, were prepared and estimated their shape and size of the holes. We also examined several reactions towards their derivatization and chemical modification.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により我々が開発した新規蛍光染料である2-スルファニルヒドロキノン二量体がバイオイメージング材料として利用可能であることを明らかにした。この成果は生化学分野に新しい検出材を提供することが期待され、この分野の発展に寄与する成果である。また新規大環状化合物のデルタアレーンの化学の基礎的な研究を進め、この化合物群を新しい分子ホストとして活用できる足がかりを得た。この成果も生化学をはじめ材料開発にも新しい方法論をもたらすことが期待できる。
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Report
(5 results)
Research Products
(22 results)
