| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
This research program aims at the development of efficient catalytic processes for the production of high-value chemicals via an ingenious design of catalyst system. Catalytic asymmetric carbon-carbon bond-forming reactions utilizing 7-azaindoline amides has reached its completion, incorporating carbon-, nitrogen-, oxygen-, sulfur-, halogen-functionalized amides at alpha-position to provide a wide range of acyclic chiral building blocks in a highly diastereo- and enantioselective fashion. As for DATB catalysis for efficient amide production from carboxylic acids and amines, mechanistic details have been revealed by systematic kinetic and DFT studies. Further investigation identified a readily accessible new catalyst derivative that is synthesized from inexpensive materials in a 3-step column free process, which is now commercial available on a worldwide basis.
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