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Synthesis and characterization of metallo-DNA nanowire with infinite, uninterrupted one-dimensional metal ions array

Research Project

Project/Area Number 17H03033
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic chemistry
Research InstitutionKanagawa University

Principal Investigator

Ono Akira  神奈川大学, 工学部, 教授 (10183253)

Co-Investigator(Kenkyū-buntansha) 近藤 次郎  上智大学, 理工学部, 准教授 (10546576)
實吉 尚郎  滋賀医科大学, 医学部, 助教 (10564784)
山田 亮  大阪大学, 基礎工学研究科, 准教授 (20343741)
田中 好幸  徳島文理大学, 薬学部, 教授 (70333797)
鳥越 秀峰  東京理科大学, 理学部第一部応用化学科, 教授 (80227678)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
KeywordsDNA nanowire / DNA Supermolecule / Molecular architecture / metallo-DNA/RNA / metallo-base pairs / crystal structure / Molecule Conductance / DNA/RNA synthesis / Crystal structure / matallo-base pair / 超分子 / 金属錯体 / オリゴヌクレオチド合成 / 金属含有DNA二重鎖 / DNAナノワイヤー / 結晶構造 / DNA超分子 / Ag-DNA wire / Hg-DNA wire / 単分子導電性 / 金属イオン-核酸 / DNAナノワーヤー / 光連結法 / ナノワイヤー / DNA二重鎖
Outline of Final Research Achievements

For developing functional nanomaterials such as nanowires, we have engaged in synthesizing DNA structure based one dimensional metal complexes (metallo-DNA nanowires). We have reported a crystal structure of Ag-DNA wires in which silver ions are uninterruptedly arrayed in DNA duplexes, and a crystal structure of Hg-DNA wires. Also, we have developed a procedure for preparing DNA duplex in which Ag ions were accumulated in a high density. The reports have been published in highly rated scientific journals and a structure was selected as a cover picture.
We have started to prepare metallo-DNA wires which are stable in solutions. Also, we have started to measure electrical conductance of DNA duplex having metallo-base pairs.

Academic Significance and Societal Importance of the Research Achievements

本研究で合成したDNAを基盤構造とする一次元超錯体(金属ナノワイヤー)は、新規構造を有していること、導電性ナノワイヤーや磁性体開発の基盤構造となる可能性があることが評価され、世界的に著名な学術雑誌に掲載されている。重要論文に認定され、また表紙画像として採用されていること、学術的に高い評価を得ている証である。今すぐに製品開発に結び付く等、実用的に利用されるものではないが、将来、ナノサイエンスの発展に寄与する研究成果である。社会的意義は、将来、科学技術の発展に貢献する可能性を有することである。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (38 results)

All 2021 2020 2019 2018 2017

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (31 results) (of which Int'l Joint Research: 9 results,  Invited: 13 results)

  • [Journal Article] Electrical conductance measurement of HgII-mediated DNA duplex in buffered aqueous solution2020

    • Author(s)
      Ryo Yamada,Issei Nomura,Yuki Yamaguchi,Yosuke Matsuda,Yoshikazu Hattori,Hirokazu Tada,Akira Ono &Yoshiyuki Tanaka
    • Journal Title

      Nucleosides, Nucleoteides & Nucleic Acids

      Volume: 0 Issue: 8 Pages: 0-0

    • DOI

      10.1080/15257770.2020.1755044

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silver(I) ion-mediated cytosine-containing base pairs: Metal ion specificity for duplex stabilization and susceptibility toward DNA polymerases2020

    • Author(s)
      Tatsuya Funai, Megumi Aotani, Risa Kiriu, Junko Nakamura, Yuki Miyazaki, Dr. Osamu Nakagawa, Dr. Shun-ichi Wada, Prof. Dr. Hidetaka Torigoe, Prof. Dr. Akira Ono and Prof. Dr. Hidehito Urata
    • Journal Title

      ChemBioChem

      Volume: 21 Issue: 4 Pages: 517-522

    • DOI

      10.1002/cbic.201900450

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel DNA helical wire containing Hg(II) mediated T:T and T:G pairs2019

    • Author(s)
      Akira Ono, Hiroki Kanazawa, Hikari Ito, Misato Goto, Koudai Nakamura, Hisao Saneyoshi, Jiro Kondo
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 58 Issue: 47 Pages: 16835-16838

    • DOI

      10.1002/anie.201910029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of a DNA duplex cross-linked by 6-thioguanine-6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(II) ions and glutathione2019

    • Author(s)
      Akira Ono, Takahiro Atsugi, Misato Goto, Hisao Saneyoshi, Takahito Tomori, Kohji Seio, Takenori Dairaku and Jiro Kondo
    • Journal Title

      RSC Adv

      Volume: 9 Issue: 40 Pages: 22859-22862

    • DOI

      10.1039/c9ra03515j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct observation of the double-stranded DNA formation through metal ion-mediated base pairing in the nanoscale structure2019

    • Author(s)
      X. Xing, Y. Feng, Z. Yu, K. Hidaka, F. Liu, A.Ono, H. Sugiyama, M. Endo
    • Journal Title

      Chemistry - A European Journal

      Volume: 25 Issue: 6 Pages: 1446-1450

    • DOI

      10.1002/chem.201805394

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crystal structure of a DNA duplex containing four Ag(I) ions in consecutive dinuclear Ag(I)-mediated base pairs: 4-thiothymine-2Ag(I)-4-thiothymine2017

    • Author(s)
      Akira Ono, Toru Sugawara, Hisao Saneyoshi, Jiro Kondo
    • Journal Title

      Chemical Communications

      Volume: 53 Issue: 86 Pages: 11747-11750

    • DOI

      10.1039/c7cc06153f

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A metallo-DNA nanowire with uninterrupted one-dimensional silver array2017

    • Author(s)
      Jiro Kondo, Yoshinari Tada, Takenori Dairaku, Yoshikazu Hattori, Hisao Saneyoshi, Akira Ono, Yoshiyuki Tanaka,
    • Journal Title

      Nature Chemistry

      Volume: 9 Issue: 10 Pages: 956-960

    • DOI

      10.1038/nchem.2808

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 短鎖 Ag-DNAワイヤーの溶液中での形成と結晶構造2021

    • Author(s)
      厚木 隆裕、近藤 次郎、小野 晶
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] チオール側鎖を有するオリゴヌクレオチドの合成と高次構造形成2021

    • Author(s)
      三上 智紀、小野 晶
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 塩基部修飾オリゴヌクレオチドの合成と高次構造形成2021

    • Author(s)
      鈴木 海斗、藤原 章司、小野 晶
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] DMSO中におけるシチジン/AgI (2:1)錯体の還元電位2020

    • Author(s)
      川井 李佳、大樂 武範、小野 哲也、吉田 健太郎、近藤 次郎、小野 晶、田中 好幸、柏木 良友
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 2 本鎖 DNA の融解温度の上昇が金属イオンとミスマッチ塩基 対の特異的結合を必ずしも示すわけではない2020

    • Author(s)
      荒川章 裕、木田隼英、安達咲希、小野 晶、浦田秀仁、平林 佳、鳥越秀峰
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Novel Structures of modified oligonucleotides and oligonucleotide-metal complexes Akira Ono, Takahiro Atsugi, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo2019

    • Author(s)
      Akira Ono, Takahiro Atsugi, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo
    • Organizer
      The 46th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of metal-DNA wires containing metallo-base pairs2019

    • Author(s)
      Takahiro Atsugi, Akira Ono
    • Organizer
      The 46th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparations of modified oligonucleotides with mirror image helical structures.2019

    • Author(s)
      Hiroyuki Fujita, Naoki Fushimi, Akira Ono
    • Organizer
      The 46th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] サイクリックボルタンメトリーを用いたメタロ塩基対の酸化還元特性の解析2019

    • Author(s)
      奥山 まりん, 大樂 武範, 小野 哲也, 吉田 健太郎, 金場 哲平, 佐藤 一, 近藤 次郎, 小野 晶, 田中 好幸, 柏木 良友
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 5-フルオロウラシル塩基を含むミスマッチ塩基対と金属イオンの特異的結合2019

    • Author(s)
      安達咲希, 荒川章裕, 小野晶, 鳥越秀峰
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Thermodynamic Properties of the Specific Binding of 4-Thiothymine to Each of Thymine and Cytosine in Mismatched Duplex DNA by Different Metal Ions2018

    • Author(s)
      Ayami Yaguchi, Akira Ono, Jiro Kondo, Hidetaka Torigoe
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Metal-mediated base pairs; the modification of DNA for future nano-electronics2018

    • Author(s)
      Vladimir Sychrovsky, Jakub Sebera, Yoshiyuki Tanaka, Akira Ono, Jiri Fukal, Magdalena Hromadova, Viliam Kolivoska
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Consecutive formation of thymine-HgII -thymine base pairs catalyzed by DNA polymerases2018

    • Author(s)
      Hidehito Urata, Tatsuya Funai, Chizuko Tagawa, Akira Ono, Shun-ichi Wada
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Effects of Hg(II) and Ag(I) on the structure of the rRNA A site molecular switches2018

    • Author(s)
      Miki Nagashima, Chiharu Suzuki, Akari Tsudura, Yuriko Uchida, Kenta Kubodera, Akira Ono, Jiro Kondo
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Crystal structures of DNA and RNA duplexes containing gold- and copper-mediated base pairs2018

    • Author(s)
      Erika Iwase, Yoshinari Tada, Akira Ono, Jiro Kondo
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Thermodynamic Properties of the Specific Binding between Metal Ion and Mismatched Base Pairs Involving 5-Hydroxyuracil or 5-Hydroxycytosines2018

    • Author(s)
      Fumihiro Arakawa, Ayami Yaguchi, Akira Ono, Jiro Kondo, Hidetaka Torigoe
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Specific Binding between Metal Ion and Mismatched Base Pair Involving 5-Carboxycytosines2018

    • Author(s)
      Saki Adachi, Fumihiro Arakawa, Akira Ono, Hidetaka Torigoe
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Structure analyses of a novel DNA helical wire containing Hg(II) -mediated T:T and T:G base pairs2018

    • Author(s)
      Akira Ono, Hiroki Kanazawa, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Preparations and structure elucidations of metallo-DNAs: DNA nanowire with uninterrupted one-dimensional silver ion array2018

    • Author(s)
      Akira Ono, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
    • Organizer
      23th International Round Table on Nucleosides, Nucleotides and Nucleic Acids
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Synthesis and metal ion binding properties of duplexes containing thymine analogs with 1,2-diamine groups2018

    • Author(s)
      Takahiro Atsugi, Hisao Saneyoshi, Akira Ono
    • Organizer
      23th International Round Table on Nucleosides, Nucleotides and Nucleic Acids
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 多核NMR 分光法によるメタロ塩基対の構造決定2018

    • Author(s)
      大樂 武範, 古板 恭子, 佐藤 一, 小野 哲也, 吉田 健太郎, 柏木 良友, 中島 勝幸, 近藤 次郎, 根東 義則, 小野 晶, 児嶋 長次郎, 田中 好幸
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Crystallographic studies of metallo-DNA nanostructures2017

    • Author(s)
      近藤次郎
    • Organizer
      Symposium on Frontier of Biofunctional Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA構造バイオナノテクノロジー2017

    • Author(s)
      近藤次郎
    • Organizer
      平成29年度日本結晶学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 金・銅仲介塩基対を含むRNAのX線結晶解析2017

    • Author(s)
      岩瀬襟伽、多田能成、近藤次郎
    • Organizer
      平成29年度日本結晶学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Specific Binding between Metal Ion and Mismatched Base Pair Involving 5-Position Modified Cytosines2017

    • Author(s)
      Fumihiro Arakawa, Ayami Yaguchi, Akira Ono, Hidetaka Torigoe
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of long DNA wires containing metallo-base pairs2017

    • Author(s)
      Kenta Ishikawa, Hisao Saneyoshi, Akira Ono
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crystal structures of oligonucleotides having metallo-base pairs2017

    • Author(s)
      Akira Ono, Toru Sugawara, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and duplex formation of oligonucleotides with 1,2-diamine groups2017

    • Author(s)
      Takahiro Atsugi, Hisao Saneyoshi, Akira Ono
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Specific Binding between Metal Ion and Mismatched Base Pair Involving 4-Thiothymine2017

    • Author(s)
      Yaguchi, A., Ono, A., Torigoe, H
    • Organizer
      第27回金属の関与する生体関連反応シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Specific Binding between Metal Ion and Mismatched Base Pair Involving 5-Hydroxyuracil2017

    • Author(s)
      Arakawa, F., Yaguchi, A., Ono, A., Torigoe, H
    • Organizer
      第27回金属の関与する生体関連反応シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characterization of DNA duplexes containing metal ion mediated base pairs2017

    • Author(s)
      Akira Ono, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
    • Organizer
      17th Symposium on Chemistry of Nucleic Acid Components
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2022-01-27  

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