| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
In this research, we tried to develop a new catalyst for enantio-induction. The generation of active metal species for C-H activation under unique chiral environment was the key. To achieve original and novel chiral system, dinucleating Schiff base system was designed. After intensive optimization of the catalyst structure and catalysts modules, we found that the chiral dinuclear Schiff base catalyst consisted of chiral binaphthyl diamine, chiral sulfoxide unit, palladium and copper was the best, showing high catalytic activity as well as enantioselctivity in intramolecular allylic C-H amination reactions. Broad substrate scope was also confirmed using the Pd-Cu Schiff base catalyst.
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