| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
In this study, a novel catalytic reaction between conjugated dienes and alkynes catalyzed by Ru(0) complexes to form conjugated trienes and tetraenes was established. In particular, following reactions between the boron-substituted conjugated dienes and alkynes, cross-coupling reactions led to the total synthesis of the marine natural product Navenone B and the formal synthesis of the apoptosis control molecule Bongkrekic acid. In addition, a novel method for the synthesis of polysubstituted pyrroles was discovered, in which the reaction of an iminoalkyne with a conjugated diene leads to the formation of a conjugated triene with a nitrogen substituent followed by aromatization. The reaction was also found to be effective for the π-conjugation extension of organic semiconducting materials and other materials.
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