| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
|---|
| Outline of Final Research Achievements |
In order to control various stereo- and substrate-specific functions of an enzyme with a large molecular weight by small molecular catalysts, it is necessary to overcome the limit of the design of the conventional catalysts. In the present study, we designed several small key molecules with appropriate acid and base points, and the corresponding chiral supramolecular catalysts were generated in situ driven by dynamic attractive interactions among the acid and base functions. The functions of keyhole and active site of the artificial-enzyme could be created in the chiral cavity of the supramolecular catalysts, and the cage effect could be induced effectively. Overall, we have succeeded in the purpose of this research to create a tailor-made chiral supramolecular catalysts that enables difficult multiselective catalytic reactions while maximizing the reaction efficiency.
|
