Artificial Enzymes base on Metalated Peptides
| Project/Area Number |
17H03056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
Takaya HIkaru 京都大学, 化学研究所, 准教授 (50304035)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | メタル化アミノ酸 / メタル化ペプチド / 金属配列制御 / 超分子錯体 / 人工酵素 / ペプチド中分子 / リグニン / リグニン親和性ペプチド / 木質バイオマス / Ru触媒 / 過酸化水素酸化 / マイクロ波 / マイクロ波有機合成 / ペプチド / リグニン認識ペプチド / 鉄触媒 / 酸化反応 / アミノ酸 / ファージディスプレイ |
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| Outline of Final Research Achievements |
To investigate programmable metal array fabrication based on metalated amino acids and peptides, where various transition-metal complexes are covalently conjugated to the alpha-side chains of amino acids and peptides. We successfully achieved the syntheses of various transition-metal complex-bound glutamines and norvalines and their peptides and finally succeeded to find their unique catalysis and self-assembly properties with the applications of supramolecular aggregates of metalated amino acids in various organic transformations, such as the cyclization of alkynes and oxidations of alcohols and methoxybenzenes under aqueous conditions. A detailed research of the mechanism of the self-assembly process and the catalytic reactions have been also achieved to prove the effectiveness of metalated amino acid- and peptide-based metal array fabrication in the design of advanced smart materials based on bioorganometallic compounds.
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| Academic Significance and Societal Importance of the Research Achievements |
人類社会の物質生産基盤を担う様々な金属錯体触媒は，天然の酵素にない触媒機能を実現し，活性や耐久性は酵素のそれを遥かに凌駕する。しかし，多種多様な分子が高密度に混在する分子夾雑系における基質選択的反応については，酵素を凌駕する金属触媒は開発されていない。特に生体組織の様に夾雑な分子環境において，狙った基質から，必要な反応のみを引き起こし，所望の物質を生産できる人工酵素の開発は，有機合成化学における未踏領域の開拓につながる。本研究では木質夾雑系からリグニンを認識して精密分解できる人工酵素の開発に成功し，将来のSDGs達成に必要な未利用バイオマスからの触媒的な有用物質生産法に先鞭をつけた。
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Report
(4 results)
Research Products
(91 results)
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[Presentation] Comprehensive Spectroscopic Sutdies for Identification of the Root of "Hinomaru", the Japanese Emperor Go-Daigo's Flag of the Rising Sun2019
Author(s)
Hikaru Takaya, Misao Yokoyama, Takahito Inoue, Hiroshi Uchihara , Mayu Onoda, Shinsuke Kashiwagi, Eishi Iso, Akira Ogasawara, Makoto Yamamoto, Katsuya Yamamo, Sachio Yoshioka
Organizer
Kyoto International Conference Center, ICOM 2019 Kyoto
Related Report
Int'l Joint Research / Invited
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[Presentation] Oxidative Degradation of Lignin and Its Related Compounds Catalyzed by Metalated Amino Acids Bearing ONO-PincerRuthenium Complexes2018
Author(s)
Takafumi Shanoh, Ryota Yoshida, Tomoya Yokoi, Katsuhiro Isozaki, Hiroshi Nishimura,Satoshi Oshiro, Keiko Kondo, Takashi Watanabe, Masato Katahira, Hikaru Takaya, Masaharu Nakamura
Organizer
The 43rd International Conference on Coordination Chemistry
Related Report
Int'l Joint Research
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