| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
To investigate programmable metal array fabrication based on metalated amino acids and peptides, where various transition-metal complexes are covalently conjugated to the alpha-side chains of amino acids and peptides. We successfully achieved the syntheses of various transition-metal complex-bound glutamines and norvalines and their peptides and finally succeeded to find their unique catalysis and self-assembly properties with the applications of supramolecular aggregates of metalated amino acids in various organic transformations, such as the cyclization of alkynes and oxidations of alcohols and methoxybenzenes under aqueous conditions. A detailed research of the mechanism of the self-assembly process and the catalytic reactions have been also achieved to prove the effectiveness of metalated amino acid- and peptide-based metal array fabrication in the design of advanced smart materials based on bioorganometallic compounds.
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