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Semiconductor-based chemical imaging sensor platform for realization of high-definition images of 10 megapixels

Research Project

Project/Area Number 17H03074
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Analytical chemistry
Research InstitutionTohoku University

Principal Investigator

Yoshinobu Tatsuo  東北大学, 医工学研究科, 教授 (30243265)

Co-Investigator(Kenkyū-buntansha) 宮本 浩一郎  東北大学, 工学研究科, 准教授 (70447142)
WERNER Frederik  京都工芸繊維大学, 電気電子工学系, 助教 (90791434)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords化学センサ / LAPS / 化学イメージセンサ
Outline of Final Research Achievements

For realization of a high-definition chemical imaging sensor system, methods to improve the spatial resolution, to shorten the measurement time, and to use a large-area sensing plate were developed. The spatial resolution was improved by using a hybrid illumination that suppressed the lateral diffusion of photocarriers in the semiconductor layer. The measurement time was shortened by parallel readout of data using a plurality of light probes. A distributed-element model was constructed to evaluate the influence of a large-area sensing plate, and the dependence on various parameters such as the frequency, the conductivity of the solution, and the series resistance was investigated. The developed chemical imaging sensor system was applied to visualization of the corrosion process on a metal surface and the metabolism of microorganisms.

Academic Significance and Societal Importance of the Research Achievements

化学イメージセンサは、試料をセンサ面に載せるだけの簡便な操作によって無機・有機・生物試料などさまざまな試料内のpHやイオン・分子の濃度分布を画像化することができる汎用的な測定プラットフォームであり、想定される応用範囲は非常に広い。本研究によって、化学イメージセンサの高画素数化に必要な、空間分解能の向上、測定時間の短縮、大面積センサ基板使用のための指針が得られたことにより、試料の細部を高精細に観察することが可能になったため、電気化学、材料科学、生物学のさまざまな分野における化学物質の可視化ツールとしての有用性が向上したほか、微小流体デバイスとの複合による診断デバイスへの応用の可能性が広がった。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (45 results)

All 2021 2020 2019 2018 2017

All Journal Article (13 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 13 results,  Open Access: 5 results) Presentation (32 results) (of which Int'l Joint Research: 24 results,  Invited: 4 results)

  • [Journal Article] Miniature multiplexed label-free pH probe in vivo2021

    • Author(s)
      Guo Yuanyuan、Werner Carl Frederik、Handa Shoma、Wang Mengyun、Ohshiro Tomokazu、Mushiake Hajime、Yoshinobu Tatsuo
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 174 Pages: 112870-112870

    • DOI

      10.1016/j.bios.2020.112870

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-addressable potentiometric sensors for cell monitoring and biosensing2021

    • Author(s)
      Yoshinobu Tatsuo、Schoening Michael J.
    • Journal Title

      Current Opinion in Electrochemistry

      Volume: 28 Pages: 100727-100727

    • DOI

      10.1016/j.coelec.2021.100727

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SUS304のすきま内pHと金属溶解速度に基づく再不働態化過程の考察2021

    • Author(s)
      野瀬清美, 松橋亮, 梶村治彦, 宮本浩一郎, 吉信達夫
    • Journal Title

      材料と環境

      Volume: 70 Pages: 131-139

    • NAID

      130008102198

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Hydrogen Permeation through Pure Iron with a Semiconductor-based Chemical Sensor2021

    • Author(s)
      K. Miyamoto, M. Kaneko, M. Wang, C. F. Werner, T. Yoshinobu
    • Journal Title

      ISIJ International

      Volume: 61

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimation of Potential Distribution during Crevice Corrosion through Analysis of I?V Curves Obtained by LAPS2020

    • Author(s)
      Nose Kiyomi、Miyamoto Ko-ichiro、Yoshinobu Tatsuo
    • Journal Title

      Sensors

      Volume: 20 Issue: 10 Pages: 2873-2873

    • DOI

      10.3390/s20102873

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 半導体化学センサで測定したステンレス鋼のすきま内pHとすきま腐食挙動との関係2020

    • Author(s)
      野瀬清美, 梶村治彦, 宮本浩一郎, 吉信達夫
    • Journal Title

      材料と環境

      Volume: 69 Pages: 40-48

    • NAID

      130007884393

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymer-Fiber-Coupled Field-Effect Sensors for Label-Free Deep Brain Recordings2020

    • Author(s)
      Y. Guo, C. F. Werner, A. Canales, L. Yu, X. Jia, P. Anikeeva and T. Yoshinobu
    • Journal Title

      PLoS ONE

      Volume: 15 Issue: 1 Pages: e0228076-e0228076

    • DOI

      10.1371/journal.pone.0228076

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sensors and techniques for visualization and characterization of local corrosion2019

    • Author(s)
      Ko-ichiro Miyamoto and Tatsuo Yoshinobu
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 58 Issue: SB Pages: SB0801-SB0801

    • DOI

      10.7567/1347-4065/ab01da

    • NAID

      210000157683

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modeling of the Return Current in a Light-Addressable Potentiometric Sensor2019

    • Author(s)
      T. Yoshinobu, D. Sato, Y. Guo, C. F. Werner and K. Miyamoto
    • Journal Title

      Sensors

      Volume: 19 Issue: 20 Pages: 4566-4566

    • DOI

      10.3390/s19204566

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Gas-Sensitive SPIM Sensor for Detection of Ethanol Using SnO2 as Sensing Element2019

    • Author(s)
      Wang Mengyun、Truong Hoang A.、Werner Carl F.、Miyamoto Ko-ichiro、Yoshinobu Tatsuo
    • Journal Title

      physica status solidi (a)

      Volume: - Issue: 12 Pages: 1800766-1800766

    • DOI

      10.1002/pssa.201800766

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Modified Chemical Imaging Sensor System for Real-Time pH Imaging of Accelerated Crevice Corrosion of Stainless Steel2018

    • Author(s)
      Miyamoto Ko-ichiro、Sakakita Sakura、Werner Carl Frederik、Yoshinobu Tatsuo
    • Journal Title

      physica status solidi (a)

      Volume: 215 Issue: 15 Pages: 1700963-1700963

    • DOI

      10.1002/pssa.201700963

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers2018

    • Author(s)
      Miyamoto Ko-ichiro、Seki Kosuke、Suto Takeyuki、Werner Carl Frederik、Wagner Torsten、Schoning Michael J.、Yoshinobu Tatsuo
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 273 Pages: 1328-1333

    • DOI

      10.1016/j.snb.2018.07.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multi-Well Sensor Platform Based on a Partially Etched Structure of a Light-Addressable Potentiometric Sensor2018

    • Author(s)
      Truong Hoang Anh、Werner Carl Frederik、Miyamoto Ko-ichiro、Yoshinobu Tatsuo
    • Journal Title

      physica status solidi (a)

      Volume: 215 Issue: 12 Pages: 1800764-1800764

    • DOI

      10.1002/pssa.201800764

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Imaging Detection of Ethanol Vapor by Scanning Photo-induced Impedance Microscopy with Suspended-gate Structure2019

    • Author(s)
      M. Wang, H. A. Truong, C. F. Werner, K. Miyamoto and T. Yoshinobu
    • Organizer
      18th International Symposium on Olfaction and Electronic Nose (ISOEN 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In situ Observation of Crevice Corrosion by a Modified Chemical Imaging Sensor System2019

    • Author(s)
      K. Miyamoto and T. Yoshinobu
    • Organizer
      8th Kurt Schwabe Symposium (jointly organized with RSE-SEE 7)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Scanning Photo-induced Impedance Microscopy to Characterize Biodegradable Polymers2019

    • Author(s)
      C. F. Werner, S. Aoki, K. Miyamoto, T. Wagner, M. J. Schoning and T. Yoshinobu
    • Organizer
      10th International Conference on Molecular Electronics & BioElectronics (M&BE10)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SPIM Gas Sensor Equipped with a Ti/Au Thin-film Micro-heater2019

    • Author(s)
      M. Wang, H. A. Truong, C. F. Werner, K. Miyamoto and T. Yoshinobu
    • Organizer
      12th International Workshop on Engineering of Functional Interfaces (EnFI 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time Monitoring of Ion Concentration Distributions with LAPS2019

    • Author(s)
      C. F. Werner, S. Taharima, K. Miyamoto, T. Wagner, M. J. Schoning and T. Yoshinobu
    • Organizer
      12th International Workshop on Engineering of Functional Interfaces (EnFI 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] pH Change in Rhizosphere Measured by a LAPS2019

    • Author(s)
      C. F. Werner, D. Sato, K. Miyamoto, T. Wagner, M. J. Schoning and T. Yoshinobu
    • Organizer
      12th International Workshop on Engineering of Functional Interfaces (EnFI 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大面積化学イメージセンサシステムの構築と植物根圏pHの観察2019

    • Author(s)
      宮本浩一郎, 佐藤大介, WERNER Frederik, 吉信達夫
    • Organizer
      第66回化学センサ研究発表会(2019年電気化学秋季大会シンポジウム)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Biochemical Sensors Coupled with Multifunctional Fibers for Label-free Imaging in the Brain and Beyond2019

    • Author(s)
      Y. Guo, S. Handa, C. F. Werner, K. Miyamoto, P. Anikeeva and T. Yoshinobu
    • Organizer
      13th Asian Conference on Chemical Sensors (ACCS 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impedance Mapping of Cell Layer Cultured on Field-Effect Chemical Sensor2019

    • Author(s)
      K. Miyamoto, D. Suzuki, C. F. Werner and T. Yoshinobu
    • Organizer
      8th International Symposium on Control of Semiconductor Interfaces (ISCSI-VIII)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 半導体化学センサによるイメージング法と応用2019

    • Author(s)
      宮本浩一郎
    • Organizer
      電気化学会東北支部第50回セミコンファレンス/第32回東北若手の会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Multi-well Sensor Platform Based on a Partially Etched Structure of Light-addressable Potentiometric Sensor2018

    • Author(s)
      H. A. Truong, K. Miyamoto, C. F. Werner and T. Yoshinobu
    • Organizer
      22nd Topical Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization of the Barrier Function of an Epithelial Cell Layer by Chemical Imaging Sensor and its Future Application2018

    • Author(s)
      K. Miyamoto, D. Suzuki, S. Uno, C. F. Werner, Y. Yanase and T. Yoshinobu
    • Organizer
      22nd Topical Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gas-imaging Sensor Based on Metal Oxide and Field Effect Structure2018

    • Author(s)
      M. Wang, K. Miyamoto, H. A. Truong, C. F. Werner and T. Yoshinobu
    • Organizer
      22nd Topical Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Light Intensity towards the Signal of a Light-addressable Potentiometric Sensor2018

    • Author(s)
      C. F. Werner, K. Miyamoto, M. J. Schoning, T. Wagner and T. Yoshinobu
    • Organizer
      22nd Topical Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Gas-sensitive SPIM Sensor for Detection of Ethanol Using SnO2 as Sensing Element2018

    • Author(s)
      M. Wang, H. A. Truong, C. F. Werner, K. Miyamoto and T. Yoshinobu
    • Organizer
      11th International Workshop on Engineering of Functional Interfaces (EnFI 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of Biodegradable Polymers with Scanning Photo-induced Impedance Microscopy2018

    • Author(s)
      C. F. Werner, S. Aoki, K. Miyamoto, T. Wagner, M. J. Schoning and T. Yoshinobu
    • Organizer
      11th International Workshop on Engineering of Functional Interfaces (EnFI 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] pH Imaging of Ion Diffusion at Laminar Flow Interface and Estimation of Diffusion Coefficients2018

    • Author(s)
      K. Miyamoto, S. Naito, C. F. Werner. S. Uno and T. Yoshinobu
    • Organizer
      17th International Meeting on Chemical Sensors (IMCS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microwell-based Microfluidic Device to Estimate the Living Cell Concentration2018

    • Author(s)
      C. F. Werner, S. Kawashima, K. Miyamoto and T. Yoshinobu
    • Organizer
      6th International Symposium on Sensor Science (I3S 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Chemical Imaging Sensor with Multi-well Structure for High-throughput Analysis2018

    • Author(s)
      H. A. Truong, C. F. Werner, K. Miyamoto and T. Yoshinobu
    • Organizer
      6th International Symposium on Sensor Science (I3S 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impedance Mapping of a Defect in a Cell Layer Cultured Directly on a Chemical Imaging Sensor2018

    • Author(s)
      K. Miyamoto, D. Suzuki, C. F. Werner and T. Yoshinobu
    • Organizer
      Electrochemical Micro & Nano System Technologies 2018 (EMNT 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Applications of Chemical Imaging Sensor in the Field of Electrochemistry2018

    • Author(s)
      K. Miyamoto and T. Yoshinobu
    • Organizer
      2018 International Conference on Solid-State Devices and Materials (SSDM 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 隙間腐食に伴うpH変化と表面形態変化の同時観察2018

    • Author(s)
      宮本浩一郎, 平光凛也, 榊田さくら, C. F. Werner, 吉信達夫
    • Organizer
      腐食防食学会 材料と環境2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化学イメージセンサを用いた細胞層創傷の経時変化観察2018

    • Author(s)
      鈴木大輔, Frederik Werner, 宮本浩一郎, 吉信達夫
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化学イメージセンサ表面の疎水・親水パターニングによる自発的液滴形成2018

    • Author(s)
      鑓水大和, Frederik Werner, 宮本浩一郎,吉信達夫
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大面積化学イメージセンサの開発と評価2018

    • Author(s)
      佐藤大介, Frederik Werner, 宮本浩一郎, 吉信達夫
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A Gas-Sensitive SPIM Sensor with Suspended Gate for Detection of Ethanol Vapor Using SnO2 as Sensing Element2018

    • Author(s)
      王孟云, チューン ホアンアン, フレデリック ヴェルナー, 宮本浩一郎, 吉信達夫
    • Organizer
      第64回化学センサ研究発表会(2018年電気化学秋季大会シンポジウム)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Applications of a Chemical Imaging Sensor to Micro-volume Samples2017

    • Author(s)
      K. Miyamoto and T. Yoshinobu
    • Organizer
      Engineering of Functional Interfaces 2017 (EnFI2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A Partially Etched Structure of Light-addressable Potentiometric Sensor for High-resolution and High-speed Chemical Imaging2017

    • Author(s)
      H. A. Truong, C. F. Werner, K. Miyamoto and T. Yoshinobu
    • Organizer
      Engineering of Functional Interfaces 2017 (EnFI2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lateral Resolution of a Light-addressable Sensor with Regard to Modulation Frequency and Light Intensity2017

    • Author(s)
      C. F. Werner, K. Miyamoto, T. Wagner, M. J. Schoening and T. Yoshinobu
    • Organizer
      Engineering of Functional Interfaces 2017 (EnFI2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor2017

    • Author(s)
      T. Suto, K. Miyamoto, C. F. Werner, T. Wagner, M. J. Schoening and T. Yoshinobu
    • Organizer
      Eurosensors 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multi-sample pH Sensor Based on Chemical Imaging Sensor with a Partially Etched Structure2017

    • Author(s)
      H. A. Truong, C. F. Werner, K. Miyamoto and T. Yoshinobu
    • Organizer
      第78会応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] On the Possibility of LAPS as a Sensing Element in Microfluidic Devices2017

    • Author(s)
      T. Yoshinobu
    • Organizer
      12th Asian Conference on Chemical Sensors (ACCS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2022-01-27  

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