Shape optimization of Thermal-Fluids Systems by Learning from Vascular Network Remodeling
| Project/Area Number |
17H03170
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Fluid engineering
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
松永 行子 (津田行子) 東京大学, 生産技術研究所, 准教授 (00533663)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Keywords | 毛細血管網 / 流路ネットワーク最適化 / プルーニング / ネットワーク最適化 / 流体工学 / 熱工学 / 流体力学 |
|---|
| Outline of Final Research Achievements |
Focusing on the processes of vascular network formation in mouth retina, we develop a scheme for obtaining the structures of vascular network before and after pruning from a confocal image of a single sample. This allows us to analyze the impact of pruning on blood flow distribution by using computational fluid dynamics. Through the analysis, we found clear and distinct trends of pruning close to the inlet of the artery and the angiogenic front. Based on such findings, we develop a new strategy for optimizing fluid network structure.
|
| Academic Significance and Societal Importance of the Research Achievements |
一般に、悪性腫瘍の周辺の血管網は、正常な組織のそれと比べて、より密な構造となることが知られている。本研究の結果は、このような血管の異常化を伴う患部近傍における流れは、血流分布に大きな影響を受けるとともに、血流に伴う薬剤等の輸送に対しても影響を与えることを示唆するものであり、これまでの医療指針に見直しを迫るものである。また、本研究で構築されたプルーニングモデルは、様々な熱流体機器における流路ネットワークの最適化において新しい設計指針を与えるものである。
|
Report
(4 results)
Research Products
(55 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Transcriptomic Analysis of Breast Cancer Stem Cells and Development of a pALDH1A1:mNeptune Reporter System for Live Tracking2019
Author(s)
N. Bidan, J. Bailleul-Dubois, J. Duval, M. Winter, M. Denoulet, K. Hannebicque, IY El-Sayed, C. Ginestier, V. Forissier, Y.T. Matsunaga, S. Meignan, F. Anquez, S. Julien, A. Bonnefond, M. Derhourhi, X.L., Bourhis, C. Lagadec
-
Journal Title
Proteomics
Volume: 19
Issue: 21-22
Pages: 21-22
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Comparison of Multi-scale Models for Blood Flow in Zebrafish Brain2019
Author(s)
Yin, M., Zheng, X., Blumers, A., Nakakura, M., Nakajima, H., Hasegawa, Y., Karniadakis, G.
Organizer
72nd Annual Meeting of the APS Division of Fluid Dynamics
Related Report
Int'l Joint Research
-
[Presentation] Numerical study on Hemodynamics of brain vasculature in eartly ebrafish life2019
Author(s)
Yin, M., Zheng, X., Blumers, A., Nakakura, M., Nakajima, H., Hasegawa, Y., Karniadakis, G.
Organizer
Biomedical Engineering Society 2019 (BMES2019)
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
