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Ultrahigh accuracy of ultrasound theragnostic systems realized by technologizing and digitizing medical professional skills

Research Project

Project/Area Number 17H03200
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionThe University of Electro-Communications

Principal Investigator

KOIZUMI NORIHIRO  電気通信大学, 大学院情報理工学研究科, 准教授 (10396765)

Co-Investigator(Kenkyū-buntansha) 小木曽 公尚  電気通信大学, 大学院情報理工学研究科, 准教授 (30379549)
月原 弘之  東京大学, 大学院工学系研究科(工学部), 助教 (50431862)
西山 悠  電気通信大学, 大学院情報理工学研究科, 准教授 (60586395)
宮嵜 英世  国立研究開発法人国立国際医療研究センター, その他部局等, 診療科長 (80323666)
葭仲 潔  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (90358341)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords医療技能のデジタル化 / 医デジ化 / Me-DigIT / Medical Digitalization / 超音波ロボット / Robotic Ultrasound / NIUTS / 医療のデジタル化 / 超音波診断ロボット / 超音波診断・治療ロボット / 非侵襲超音波診断・治療統合システム / Non-Invasive Ultrasound Theragnostic System / 強力集束超音波 / 医療用ロボティックベッド / 医療ロボティクス / Robotic ultrasound / Non-Invasive ultrasound theranostic system / ロボティクス
Outline of Final Research Achievements

The purpose of this research is to establish a method for constructing an integrated ultrasonic diagnosis / treatment system that operates robustly and with high accuracy, and excellent research results regarding the core basic technology related to robot mechanism / control / image processing algorithm technology for this purpose. Have been piled up.
In particular, medical image processing technology has made epoch-making breakthroughs in the field of image processing by machine learning such as deep learning in recent years, and this project also started research on medical robot vision technology that incorporates deep learning. The results have been steadily accumulating (received the 25th Robotics Symposia Student Encouragement Award (2020), the 21st and 22nd Japan Society of Ultrasonics Medicine Encouragement Award (2020, 2021), etc.).

Academic Significance and Societal Importance of the Research Achievements

医療技能のデジタル化(医デジ化)を加速させることで時間(いつでも)・空間(どこでも)・人間(医療専門家や患者)によらず、一定水準以上の医療を実現することができるものと強く期待されている。2015年に深層学習を援用したU-Netと呼ばれる臓器抽出における強力な医用画像処理アルゴリズムが開発された。これを踏まえて本研究においても同技術を援用することで患部抽出・追従・モニタリングに関する新規のアルゴリズムをこれまでに提案してきている。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (35 results)

All 2020 2019 2018 2017 Other

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 11 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 13 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 3 results)

  • [Journal Article] Use of intra-procedural fusion imaging combining contrast-enhanced ultrasound using a perflubutane-based contrast agent and auto sweep three-dimensional ultrasound for guiding radiofrequency ablation and evaluating its efficacy in patients with hepatocellular carcinomaInternational2020

    • Author(s)
      Katsuyuki Sanga, Kazushi Numata, Hiromi Nihonmatsu, Katsuaki Ogushi, Hiroyuki Fukuda, Makoto Chuma, Hiroshi Hashimoto, Norihiro Koizumi, Shin Maeda
    • Journal Title

      Journal of Hyperthermia (IJH)

      Volume: 37 Issue: 1 Pages: 202-211

    • DOI

      10.1080/02656736.2020.1729422

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sagittal alignment in an MR-TRUS fusion biopsy using only the prostate contour in the axial image2020

    • Author(s)
      Riki Igarashi, Norihiro Koizumi, Yu Nishiyama, Kyohei Tomita, Yuka Shigenari, Sunao Shoji
    • Journal Title

      ROBOMECH Journal

      Volume: 7 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s40648-020-0155-9

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of computer-aided diagnosis system in evaluating severity of benign prostatic hyperplasia, using a super-ellipse model to characterize changes in prostate contours2020

    • Author(s)
      Sunao Shoji, Yuka Shigenari, Izumi Hanada, Tatsuya Otaki, Takahiro Ogawa, Masayoshi Kawakami, Hakushi Kim, Masanori Hasegawa,Yoshiaki Kawamura, Norihiro Koizumi, Akira Miyajima
    • Journal Title

      The Journal of Urology

      Volume: 203 Issue: Supplement 4 Pages: 605-606

    • DOI

      10.1097/ju.0000000000000891.07

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Method of Medical DigITalization (Me-DigIT) and Its Effects and Social Impacts2019

    • Author(s)
      小泉憲裕, 西山 悠, 江浦史生,今泉飛翔, 大塚研秀, 佐々木雄大, 重成佑香, 五十嵐立樹, 草原健太, 小林賢人, 月原弘之, 松本直樹, 小川眞広
    • Journal Title

      Journal of the Japan Society for Precision Engineering

      Volume: 85 Issue: 9 Pages: 749-752

    • DOI

      10.2493/jjspe.85.749

    • NAID

      130007703006

    • ISSN
      0912-0289, 1882-675X
    • Year and Date
      2019-09-05
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Open Access
  • [Journal Article] Automatic Diagnosis by Compact Portable Ultrasound Robot : State Estimation of Internal Organs with Steady-State Kalman Filter2019

    • Author(s)
      Yudai Sasaki, Fumio Eura, Kento Kobayashi, Ryosuke Kondo, Kyohei Tomita, Yu Nishiyama, Hiroyuki Tsukihara, Naoki Matsumoto, and Norihiro Koizumi
    • Journal Title

      Proc. of 2019 IEEE Healthcare Innovations and Point of Care Technologies Conference (HI-POCT)

      Volume: 2019 Pages: 29-32

    • DOI

      10.1109/hi-poct45284.2019.8962758

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of compact portable ultrasound robot for home healthcare2019

    • Author(s)
      Sasaki Yudai、Eura Fumio、Kobayashi Kento、Kondo Ryosuke、Tomita Kyohei、Nishiyama Yu、Tsukihara Hiroyuki、Matumoto Naoki、Koizumi Norihiro
    • Journal Title

      The Journal of Engineering

      Volume: 2019 Issue: 14 Pages: 495-499

    • DOI

      10.1049/joe.2018.9406

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Method for Extracting Acoustic Shadows to Construct an Organ Composite Model in Ultrasound Images2018

    • Author(s)
      Akihide Otsuka, Norihiro Koizumi, Izumu Hosoi, Hiroyuki Tsukihara, Yu Nishiyama
    • Journal Title

      Proc. of 2018 15th International Conference on Ubiquitous Robots (UR2018)

      Volume: 2018 Pages: 719-722

    • DOI

      10.1109/urai.2018.8441771

    • NAID

      130007551002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Out-of-Plane Motion Detection System Using Convolutional Neural Network for US-guided Radiofrequency Ablation Therapy2018

    • Author(s)
      Ryosuke Kondo, Norihiro Koizumi, Yu Nishiyama, Naoki Matsumoto and Kazushi Numata
    • Journal Title

      Proc. of 2018 15th International Conference on Ubiquitous Robots (UR2018)

      Volume: 2018 Pages: 729-731

    • DOI

      10.1109/urai.2018.8441865

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Automatic Fascia Extraction and Classification for Measurement of Muscle Layer Thickness2018

    • Author(s)
      Tsubasa Imaizumi, Norihiro Koizumi, Ryosuke Kondo, Yu Nishiyama, Naoki Matsumoto
    • Journal Title

      Proc. of 2018 15th International Conference on Ubiquitous Robots (UR2018)

      Volume: 2018 Pages: 493-496

    • DOI

      10.1109/urai.2018.8441877

    • NAID

      130007551007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medical and bio are new digitals - Realization of ultrasound diagnosis and treatment with ultra-high precision by Me-DigIT-2018

    • Author(s)
      KOIZUMI Norihiro、SEO Joonho、LEE Deukhee、KAYASUGA Atsushi、KONDO Ryosuke、TOMITA Kyohei、HOSOI Izumu、NISHIYAMA Yu、TSUKIHARA Hiroyuki、MIYAZAKI Hideyo、FUKUDA Hiroyuki、NUMATA Kazushi、YOSHINAKA Kiyoshi、AZUMA Takashi、SUGITA Naohiko、HONMA Yukio、MATSUMOTO Yoichiro、MITSUISHI Mamoru
    • Journal Title

      Choonpa Igaku

      Volume: 45 Issue: 2 Pages: 173-182

    • DOI

      10.3179/jjmu.JJMU.R.125

    • NAID

      130006496705

    • ISSN
      1346-1176, 1881-9311
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Servoing Performance Enhancement via a Respiratory Organ Motion Prediction Model for a Non-Invasive Ultrasound Theragnostic System2017

    • Author(s)
      Tatsuya Fujii, Norihiro Koizumi, Atsushi Kayasuga, Dongjun Lee, Hiroyuki Tsukihara, Hiroyuki Fukuda, Kiyoshi Yoshinaka, Takashi Azuma,Hideyo Miyazaki, Naohiko Sugita, Kazushi Numata, Yukio Honma, Yoichiro Matsumoto, Mamoru Mitsuishi
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: 29 Issue: 2 Pages: 434-446

    • DOI

      10.20965/jrm.2017.p0434

    • NAID

      130007519865

    • ISSN
      0915-3942, 1883-8049
    • Year and Date
      2017-04-20
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel and Simple Ultrasonographic Methods for Estimating the Abdominal Visceral Fat Area2017

    • Author(s)
      Asano Takeharu、Kubota Naoto、Koizumi Norihiro、Itani Kazunori、Mitake Tsuyoshi、Yuhashi Kazuhito、Liao Hongen、Mitsuishi Mamoru、Takeishi Shigemi、Takahashi Toshiaki、Ohnishi Shin、Sasaki Shiro、Sakuma Ichiro、Kadowaki Takashi
    • Journal Title

      Int J Endocrinol.

      Volume: 2017 Pages: 1-12

    • DOI

      10.1155/2017/8796069

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new device for fiducial registration of image-guided navigation system for liver RFA2017

    • Author(s)
      Doba Nobutaka、Fukuda Hiroyuki、Numata Kazushi、Hao Yoshiteru、Hara Kouji、Nozaki Akito、Kondo Masaaki、Chuma Makoto、Tanaka Katsuaki、Takebayashi Shigeo、Koizumi Norihiro、Kobayashi Akira、Tokuda Junichi、Maeda Shin
    • Journal Title

      International Journal of Computer Assisted Radiology and Surgery

      Volume: 13 Issue: 1 Pages: 115-124

    • DOI

      10.1007/s11548-017-1647-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Deep Learning Based 3-Dimensional Liver Motion Estimation Using 2-Dimensional Ultrasound Images2019

    • Author(s)
      Tsubasa Imaizumi, Ryosuke Kondo, Kenta Kusahara, Yu Nishiyama, Hiroyuki Tsukihara, Naoki Matsumoto, Kazushi Numata, Norihiro Koizumi
    • Organizer
      2019 IEEE International Conference on Cyborg and Bionic Systems (CBS 2019)
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lesion Tracking Method Using CNN in Non-Invasive Ultrasound Diagnostic Treatment Integrated System2019

    • Author(s)
      Riki Igarashi, Kyohei Tomita, Yu Nishiyama, Yuka Shigenari, Norihiro Koizumi
    • Organizer
      2019 IEEE International Conference on Cyborg and Bionic Systems (CBS 2019)
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Bed-Type Ultrasound Diagnosis and Therapeutic Robot2019

    • Author(s)
      Kento Kobayashi, Yudai Sasaki, Fumio Eura, Ryosuke Kondo, Kyohei Tomita, Takahiro Kobayashi, Yusuke Watanabe, Akihide Otsuka, Hiroyuki Tsukihara, Naoki Matsumoto, Kazushi Numata, Hidetoshi Nagaoka, Toshiyuki Iwai, Hideyuki Iijima, Yu Nishiyama, Norihiro Koizumi
    • Organizer
      2019 IEEE International Conference on Cyborg and Bionic Systems (CBS 2019)
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Matching axial images of magnetic resonance imaging and transrectal ultrasound based on deep learning2019

    • Author(s)
      Riki Igarashi, Norihiro Koizumi, Yu Nishiyama, Kyohei Tomita, Yuka Shigenari, Sunao Shoji
    • Organizer
      33rd International Congress and Exhibition on computer assisted radiology and surgery (CARS 2019)
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Segmentation of liver parenchyma in ultrasound images for automatic diagnosis of liver cirrhosis2019

    • Author(s)
      Tsubasa Imaizumi, Norihiro Koizumi, Yu Nishiyama, Naoki Matsumoto, Masahiro Ogawa
    • Organizer
      33rd International Congress and Exhibition on computer assisted radiology and surgery (CARS 2019)
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Method for Shape Extraction and Modeling of Prostate Contours by Using Sperellipses2018

    • Author(s)
      Yuka Shigenari, Norihiro Koizumi, Kyohei Tomita, Yu Nishiyama, Sunao Shoji
    • Organizer
      2018 15th International Conference on Ubiquitous Robots (UR2018)
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Out-of-Plane Motion Detection System Using Convolutional Neural Network for US-guided Radiofrequency Ablation Therapy2018

    • Author(s)
      Ryosuke Kondo, Norihiro Koizumi, Yu Nishiyama, Naoki Matsumoto and Kazushi Numata
    • Organizer
      2018 15th International Conference on Ubiquitous Robots (UR2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Method for Extracting Acoustic Shadows to Construct an Organ Composite Model in Ultrasound Images2018

    • Author(s)
      Akihide Otsuka, Norihiro Koizumi, Izumu Hosoi, Hiroyuki Tsukihara, Yu Nishiyama
    • Organizer
      2018 15th International Conference on Ubiquitous Robots (UR2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Automatic Fascia Extraction and Classification for Measurement of Muscle Layer Thickness2018

    • Author(s)
      Tsubasa Imaizumi, Norihiro Koizumi, Ryosuke Kondo, Yu Nishiyama, Naoki Matsumoto
    • Organizer
      2018 15th International Conference on Ubiquitous Robots (UR2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Compact Portable Ultrasound Robot for Home Healthcare2018

    • Author(s)
      Yudai Sasaki, Fumio Eura, Kento Kobayashi, Ryosuke Kondo, Kyohei Tomita, Yu Nishiyama, Hiroyuki Tsukihara, Naoki Matumoto and Norihiro Koizumi
    • Organizer
      14th Annual Asian Conference on Computer Aided Surgery(ACCAS2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A study for tracking focal lesions in non-invasive ultrasound theragnostic system2017

    • Author(s)
      Kyohei Tomita, Norihiro Koizumi, Atsushi Kayasuga, Yu Nishiyama, Hiroyuki Tsukihara, Hideyo Miyazaki, Kiyoshi Yoshinaka, Mamoru Mitsuishi
    • Organizer
      2017 14th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An automatic templates selection method for ultrasound guided tumor tracking2017

    • Author(s)
      Ryosuke Kondo, Norihiro Koizumi, Kyohei Tomita, Yu Nishiyama, Hidenori Sakanashi, Hiroyuki Fukuda, Hiroyuki Tsukihara, Kazushi Numata, Mamoru Mitusishi, Yoichiro Matsumoto
    • Organizer
      2017 14th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of portable ultrasound guided physiological motion compensation device2017

    • Author(s)
      Fumio Eura, Rika Aizawa, Ryosuke Kondo, Kyohei Tomita, Yu Nishiyama, Norihiro Koizumi
    • Organizer
      2017 IEEE International Conference on Cyborg and Bionic Systems (CBS 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 人工知能と社会2018

    • Author(s)
      AIX(人工知能先端研究センター)、栗原 聡、長井 隆行、小泉 憲裕、内海 彰、坂本 真樹、久野美和子
    • Total Pages
      240
    • Publisher
      株式会社オーム社
    • ISBN
      9784274221811
    • Related Report
      2017 Annual Research Report
  • [Remarks] 電気通信大学 小泉研究室

    • URL

      http://www.medigit.mi.uec.ac.jp/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 小泉 憲裕の研究ブログ

    • URL

      http://blog2009nkoizumi.japanprize.jp/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 小泉 憲裕の研究ブログ

    • URL

      http://blog2009nkoizumi.japanprize.jp

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体内運動追跡方法およびプログラム2018

    • Inventor(s)
      小泉憲裕,西山 悠,近藤亮祐,冨田恭平,江浦史生,沼田和司
    • Industrial Property Rights Holder
      小泉憲裕,西山 悠,近藤亮祐,冨田恭平,江浦史生,沼田和司
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2020
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 生体内運動追跡方法およびプログラム2018

    • Inventor(s)
      小泉憲裕, 西山 悠, 近藤亮祐, 冨田恭平, 江浦史生, ほか
    • Industrial Property Rights Holder
      小泉憲裕, 西山 悠, 近藤亮祐, 冨田恭平, 江浦史生, ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 生体内運動追跡装置2018

    • Inventor(s)
      小泉憲裕, 栢菅 篤, 冨田恭平, 細井泉澄, 西山 悠, ほか
    • Industrial Property Rights Holder
      小泉憲裕, 栢菅 篤, 冨田恭平, 細井泉澄, 西山 悠, ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 生体内運動追跡装置2017

    • Inventor(s)
      小泉憲裕, 栢菅 篤, 冨田恭平, 細井泉澄, 西山 悠, ほか
    • Industrial Property Rights Holder
      小泉憲裕, 栢菅 篤, 冨田恭平, 細井泉澄, 西山 悠, ほか
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-040348
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体内運動追跡方法およびプログラム2017

    • Inventor(s)
      小泉憲裕, 西山 悠, 近藤亮祐, 冨田恭平, 江浦史生, ほか
    • Industrial Property Rights Holder
      小泉憲裕, 西山 悠, 近藤亮祐, 冨田恭平, 江浦史生, ほか
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-158071
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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