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Development of non-invasive blood glucose measurement system using quantum cascade lasers with multiple wavelengths

Research Project

Project/Area Number 17H03242
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Electron device/Electronic equipment
Research InstitutionTohoku University

Principal Investigator

Matsuura Yuji  東北大学, 医工学研究科, 教授 (10241530)

Co-Investigator(Kenkyū-buntansha) 片桐 崇史  富山大学, 学術研究部工学系, 教授 (90415125)
木野 彩子  東北大学, 医工学研究科, 学術研究員 (30536082)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords血糖値測定 / 赤外分光 / 量子カスケードレーザ / 中空光ファイバ / 赤外分光法 / ATR分光 / ATR分光
Outline of Final Research Achievements

We developed a system using multiple single wavelength quantum cascade lasers (QCL) for non-invasive blood glucose measurement based on infrared absorption spectroscopy. First, we selected two wavelengths: 1152 cm-1 which is one of the absorption wavelengths of glucose molecule, and 1186 cm-1 which does not show absorption. After that, we constructed a system using two QCLs of these wavelengths and measured the absorption spectrum of the lips. In order to reduce the dispersion of the measured values, we solved the non-uniformity of the optical power distribution on the prism surface. Thus, the divergence angle of the incident light was expanded and the incident angle was further reduced. As a result, the variability during repeated measurements was greatly reduced, and a correlation was observed between human blood glucose level and optical absorption level.

Academic Significance and Societal Importance of the Research Achievements

本研究では,大型の分光装置によって得られる従来の連続的なスペクトルではなく,離散的な複数の波長での吸収値のみから血糖値を導きだす手法を見出した.本研究で光源として使用した量子カスケードレーザは,小型化にはきわめて有利であり,その製造コストは,将来,飛躍的に低減されることが期待できる.そのため,本研究の成果により,今後は小型かつ安価な実用的な無侵襲血糖値測定システムの実現が期待される.非侵襲測定法が確立されれば,簡易なスクリーニングが可能となり,重症化以前にはほぼ症状が現れない早期の糖尿病を検出し,爆発的に増加しつつある患者数の増大を抑制することに貢献するものと考えられる.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (47 results)

All 2020 2019 2018 2017

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (30 results) (of which Int'l Joint Research: 15 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] Diagnosis and Healthcare Monitoring Systems Based on Infrared Spectroscopy2019

    • Author(s)
      松浦祐司
    • Journal Title

      Journal of Japanese Society of Oral Implantology

      Volume: 32 Issue: 3 Pages: 205-209

    • DOI

      10.11237/jsoi.32.205

    • NAID

      130007748793

    • ISSN
      0914-6695, 2187-9117
    • Year and Date
      2019-09-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accuracy Improvement of Blood Glucose Measurement System Using Quantum Cascade Lasers2019

    • Author(s)
      T. Koyama, S. Kino, Y. Matsuura
    • Journal Title

      Optics and Photonics Journal

      Volume: 9 Issue: 10 Pages: 155-164

    • DOI

      10.4236/opj.2019.910014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中空光ファイバを用いた赤外分光測定―無侵襲血糖値測定システム―2019

    • Author(s)
      松浦祐司
    • Journal Title

      機能材料

      Volume: 39 Pages: 39-45

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 中赤外分光法による全血中のグルコース濃度計測2019

    • Author(s)
      木野彩子, 小川貴大, 曽山俊輔, 松浦祐司
    • Journal Title

      レーザー研究

      Volume: 47 Pages: 169-172

    • NAID

      130008074021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-Invasive Blood Glucose Measurement Using Quantum Cascade Lasers2018

    • Author(s)
      Yoshioka Kiriko、Koyama Takuya、Kino Saiko、Matsuura Yuji
    • Journal Title

      Nippon Laser Igakkaishi

      Volume: 39 Issue: 2 Pages: 105-110

    • DOI

      10.2530/jslsm.jslsm-39_0018

    • NAID

      130007498270

    • ISSN
      0288-6200, 1881-1639
    • Year and Date
      2018-07-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infrared hollow optical fiber probe for localized carbon dioxide measurement in respiratory tracts2018

    • Author(s)
      T. Katagiri, K. Shibayama, T. Iida, Y. Matsuura
    • Journal Title

      Sensors

      Volume: 18 Issue: 4 Pages: 995-1002

    • DOI

      10.3390/s18040995

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Feasibility Study of Photoacoustic Detection of Hidden Dental Caries Using a Fiber-Based Imaging System2018

    • Author(s)
      Koyama Takuya、Kakino Satoko、Matsuura Yuji
    • Journal Title

      Applied Sciences

      Volume: 8 Issue: 4 Pages: 621-621

    • DOI

      10.3390/app8040621

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of Shatter-Proof Metal Hollow-Core Optical Fibers for Endoscopic Mid-Infrared Laser Applications2018

    • Author(s)
      Iwai Katsumasa、Takaku Hiroyuki、Miyagi Mitsunobu、Shi Yi-Wei、Matsuura Yuji
    • Journal Title

      Fibers

      Volume: 6 Issue: 2 Pages: 24-24

    • DOI

      10.3390/fib6020024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time-domain terahertz gas spectroscopy using hollow-optical-fiber gas cell2018

    • Author(s)
      Katagiri Takashi、Suzuki Takahiro、Matsuura Yuji
    • Journal Title

      Optical Engineering

      Volume: 57 Issue: 05 Pages: 1-1

    • DOI

      10.1117/1.oe.57.5.054104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unsupervised calibration for noninvasive glucose-monitoring devices using mid-infrared spectroscopy2018

    • Author(s)
      Kasahara Ryosuke、Kino Saiko、Soyama Shunsuke、Matsuura Yuji
    • Journal Title

      Journal of Innovative Optical Health Sciences

      Volume: 11 Issue: 06 Pages: 1850038-1850038

    • DOI

      10.1142/s1793545818500384

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中赤外光を用いた診断・ヘルスケアモニタリング2018

    • Author(s)
      松浦祐司, 小山卓耶
    • Journal Title

      光アライアンス

      Volume: 29 Pages: 36-40

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 中空光ファイバを用いた中赤外分光システムによる非侵襲血糖値測定2018

    • Author(s)
      松浦祐司
    • Journal Title

      応用物理

      Volume: 87 Pages: 171-174

    • NAID

      130007715722

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity improvement of optical fiber acoustic probe for all-optical photoacoustic imaging system2017

    • Author(s)
      A. Seki, K. Iwai, T. Katagiri, and Y. Matsuura
    • Journal Title

      Applied Physics Express

      Volume: 10 Issue: 7 Pages: 0725031-0725034

    • DOI

      10.7567/apex.10.072503

    • NAID

      210000135908

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensitivity improvement of midinfrared gas sensing system using single-wavelength quantum cascade laser and hollow-waveguide gas cell2017

    • Author(s)
      T. Katagri, K. Yaegashi, Y. Matsuura
    • Journal Title

      Opt. Eng.

      Volume: 56 Issue: 08 Pages: 080503-080503

    • DOI

      10.1117/1.oe.56.8.080503

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers2017

    • Author(s)
      R. Kasahara, S. Kino, S. Soyama, Y. Matsuura
    • Journal Title

      Biomed. Opt. Express

      Volume: 9 Issue: 1 Pages: 289-302

    • DOI

      10.1364/boe.9.000289

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中赤外光を用いたヘルスケア機器開発-非侵襲血糖測定システムの現状とこれから-2017

    • Author(s)
      松浦祐司
    • Journal Title

      OplusE

      Volume: 39 Pages: 1060-1064

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Transmission properties of dielectric-coated hollow optical fibers based on Ni-Ti tube2020

    • Author(s)
      K. Iwai, H. Takaku, M. Miyagi, Y. Shi, X. Zhu, Y. Matsuura
    • Organizer
      SPIE Conference on Quantum Sensing and Nano Electronics and Photonics XX
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-invasive measurement of blood glucose by attenuated total reflection spectroscopy with fixed-wavelength quantum cascade lasers2019

    • Author(s)
      T. Koyama, S. Kino, Y. Matsuura
    • Organizer
      Biomedical Imaging and Optical Sensing Conference (BISC) 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-invasive blood glucose measurement by using fast swept-wavelength quantum cascade laser2019

    • Author(s)
      N. Shibata, S. Kino, N. Akikusa, A. Sugiyama, Y. Matsuura
    • Organizer
      Biomedical Imaging and Optical Sensing Conference (BISC) 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of oral mucosa moisture without touching it using near-infrared2019

    • Author(s)
      S .Sugawara, Y. Matsuura
    • Organizer
      Biomedical Imaging and Optical Sensing Conference (BISC) 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] All-fiber imaging system for ultra-thin flexible endoscope based on compressed image reconstruction2019

    • Author(s)
      T. Kubota, T. Katagiri, Y. Matsuura
    • Organizer
      Micro Optics Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Compact fluorescence endoscope with speckle-generating fiber probe2019

    • Author(s)
      T. Okubo, T. Katagiri, Y. Matsuura
    • Organizer
      Micro Optics Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hollow optical fibers for laser applications2019

    • Author(s)
      Y. Matsuura
    • Organizer
      2019 International Conference on Laser Interaction with Material and Applied Laser Technology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中赤外バイオセンシング用光導波路型デバイスの高感度化2019

    • Author(s)
      菅原 崇弘, 木野 彩子, 松浦 祐司
    • Organizer
      レーザー学会学術講演会第39回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 波長掃引量子カスケードレーザを用いた血糖測定システムの測定精度向上の検討2019

    • Author(s)
      柴田 尚登, 木野 彩子, 杉山 厚志, 秋草 直大, 松浦 祐司
    • Organizer
      レーザー学会学術講演会第39回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 耳たぶを対象とした中赤外分光法による血糖値測定2019

    • Author(s)
      曽山 俊輔, 木野 彩子, 松浦 祐司
    • Organizer
      レーザー学会学術講演会第39回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 量子カスケードレーザを用いた非侵襲血糖値測定システム ―プリズムへの光入射法改善による測定精度の向上―2019

    • Author(s)
      小山 卓耶, 木野 彩子, 松浦 祐司
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Non-invasive blood glucose measurement using fixed-wavelength quantum cascade lasers2019

    • Author(s)
      T. Koyama, S. Kino, Y. Matsuura
    • Organizer
      SPIE Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fabrication of 75-um-bore hollow optical fibers for infrared transmission2019

    • Author(s)
      K. Iwai, Y. Sasaki, H. Takaku, M. Miyagi, Y. Shi, X.Zhu, Y. Matsuura
    • Organizer
      SPIE Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-invasive blood glucose measurement using quantum cascade lasers2019

    • Author(s)
      Y. Matsuura, T. Koyama
    • Organizer
      SPIE Conference on Quantum Sensing and Nano Electronics and Photonics XVI
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中赤外光を用いた非侵襲血糖値センシング ─ヘルスケア機器の開発に向けて─2018

    • Author(s)
      松浦 祐司, 吉岡 希利子, 木野 彩子
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 中赤外バイオセンシングに向けた導波路デバイスの検討2018

    • Author(s)
      菅原 崇弘, 木野 彩子, 松浦 祐司
    • Organizer
      2018年電子情報通信学会ソサイエティ大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 時間領域分光法を用いた誘電体内装テラヘルツ中空光ファイバの損失および伝搬モード特性評価2018

    • Author(s)
      柴田 諒介, 片桐 崇史, 松浦 祐司
    • Organizer
      2018年電子情報通信学会ソサイエティ大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 赤外分光法による診断・ヘルスケアモニタリング ―非侵襲血糖値測定などー2018

    • Author(s)
      松浦 祐司
    • Organizer
      第48回日本口腔インプラント学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 固定波長量子カスケードレーザを用いた無侵襲血糖値測定2018

    • Author(s)
      小山 卓耶, 吉岡 希利子, 木野 彩子, 松浦 祐司
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 波長掃引型パルス量子カスケードレーザを用いた非侵襲血糖値測定2018

    • Author(s)
      柴田 尚登, 木野 彩子, 杉山 厚志, 秋草 直大, 松浦 祐司
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中赤外ATR分光法による血中中性脂肪の代謝モニタリングの試み2018

    • Author(s)
      小川 貴大, 木野 彩子, 松浦 祐司
    • Organizer
      日本光学会年次学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Terahertz gas sensing based on time-domain-spectroscopy using a hollow optical fiber gas cell2018

    • Author(s)
      T. Suzuki, T. Katagiri, Y. Matsuura
    • Organizer
      SPIE Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Blood glucose measurement with multiple quantum cascade lasers using hollow optical fiber-based ATR spectroscopy2018

    • Author(s)
      K. Yoshioka, S. Kino, Y. Matsuura
    • Organizer
      SPIE Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fabrication of terahertz hollow-optical fiber with inner dielectric layer2017

    • Author(s)
      T. Suzuki, T. Katagiri, Y. Matsuura
    • Organizer
      Advanced Lasers and Photon Sources, ALPS’17
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Noninvasive measurement of blood glucose level using mid-infrared quantum cascade lasers2017

    • Author(s)
      K.Yoshioka, S. Kino, Y. Matsuura
    • Organizer
      Biomedical Imaging and Optical Sensing Conference (BISC) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-invasive measurement of blood glucose by using mid-infrared light2017

    • Author(s)
      Y. Matsuura
    • Organizer
      2017 International Advanced Laser Application Summit Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中赤外ATR分光法による全血の血糖値測定の試み2017

    • Author(s)
      小川 貴大, 木野 彩子, 松浦 祐司, 松浦 祐司
    • Organizer
      平成29年度電気関係学会東北支部連合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 耳たぶを対象とした赤外ATR法による非侵襲血糖値測定2017

    • Author(s)
      曽山 俊輔, 木野 彩子, 松浦 祐司
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 中赤外ATR分光法による非侵襲血糖値測定2017

    • Author(s)
      松浦 祐司
    • Organizer
      日本分析化学会第66年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 量子カスケードレーザを用いた無侵襲血糖値測定システムの開発2017

    • Author(s)
      吉岡 希利子, 木野 彩子, 松浦 祐司
    • Organizer
      第38回日本レーザー医学会総会
    • Related Report
      2017 Annual Research Report
  • [Book] 生体情報センシングとヘルスケアへの最新応用2017

    • Author(s)
      松浦祐司
    • Total Pages
      12
    • Publisher
      技術情報協会
    • ISBN
      4861046610
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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