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Study on highly sensitive detection of chemical substances that affect living body using broadband mid infrared laser

Research Project

Project/Area Number 17H03278
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionTokai University

Principal Investigator

Asobe Masaki  東海大学, 工学部, 教授 (60522000)

Co-Investigator(Kenkyū-buntansha) 立崎 武弘  東海大学, 工学部, 講師 (20632590)
鄭 和翊  東海大学, 理学部, 教授 (70399335)
加藤 明  東海大学, 医学部, 准教授 (70546746)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords波長変換 / 広帯域 / ガス / 吸収分光 / 中赤外 / 生体 / 計測システム / ガスセンシング / 広帯域分光 / 分光 / センシング
Outline of Final Research Achievements

In order to enable highly sensitive and rapid measurement of chemical substances, mid-infrared laser was used to take advantage of strong absorption of various gases. The laser was generated by using tele-com lasers and waveguide type wavelength converter. The waveguide type device had an issue of the conversion efficiency fluctuation during wavelength sweep, but this has been solved by signal processing. The frequency stability of the fiber laser was an issue, but frequency stabilization was achieved by devising the structure of the laser. We measured the absorption spectra of various organic compounds precisely by using the broadband mid-infrared laser. We also demonstrated the real time monitoring of gas concentration. In addition, by combining the real-time measurement of gas concentration and eye movement measurement of mice, we examined the effect of gas concentration on the living body and demonstrated its benefit.

Academic Significance and Societal Importance of the Research Achievements

室内の化学物質による過敏症の研究、呼気中の微量ガスの計測による疾病の予防・診断など、各種の化学物質の高感度かつ迅速な計測が期待されている。本研究では半導体レーザやファイバレーザの高効率な波長変換により、化学物質分子の基本振動による強い吸収が得られる中赤外光を発生し、微量ガスを高感度に検出する技術を開発した。特に広帯域な中赤外光を利用することにより、複雑な分子構造のガスの吸収スペクトルを計測し、ガス検出が可能な技術の開発を行った。また、生体運動計測を組み合わせることで、環境の生体に与える影響を解析し、高感度ガスセンシング技術の疾病の予防、診断や研究における有用性を実証した。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (14 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning2018

    • Author(s)
      Kakegawa, W., Katoh, A., Narumi, S., Miura, E., Motohashi, J., Takahashi, A., Kohda, K., Fukazawa, Y., Yuzaki, M., Matsuda, S.
    • Journal Title

      Neuron

      Volume: 99 Pages: 985-998

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 広帯域中赤外レーザの発生手法と期待される分光応用2017

    • Author(s)
      遊部 雅生、酒井 駿一、立崎 武弘
    • Journal Title

      Optoronics

      Volume: 36 Pages: 101-104

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 空間認知における前庭動眼反射適応のメカニズム2017

    • Author(s)
      加藤明
    • Journal Title

      Journal of the Society of Biomechanisms

      Volume: 41 Issue: 4 Pages: 171-175

    • DOI

      10.3951/sobim.41.4_171

    • ISSN
      0285-0885
    • Related Report
      2017 Annual Research Report
  • [Presentation] 波長変換による3um帯光コムを用いた真菌由来MVOCセンシング2020

    • Author(s)
      加藤 翔太,土屋 順平,萩原 武士,遠藤 祐介,遊部 雅生
    • Organizer
      レーザー学会学術講演会第40回年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 波長変換による3u;m帯光コムを用いた真菌由来MVOCの分光計測2020

    • Author(s)
      萩原 武士,遠藤 祐介,加藤 翔太,土屋 順平,遊部 雅生
    • Organizer
      第20回レーザー学会東京支部研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Wavelength Modulation Spectroscopy of Linalool using Broadband 3um Difference Frequency Laser2019

    • Author(s)
      S. Kato, H. Ishikawa, K. Uchiyama, A. Maruyama, M. Asobe, K. Tei , S. Yamaguchi, and N. Hirayama
    • Organizer
      ALPS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuropathy Target Esteraseと神経機能遺伝子操作マウスを用いた解析2019

    • Author(s)
      木村穣、阿部如子、本杉奈美、坂部貢、加藤明
    • Organizer
      第28回日本臨床環境医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neuropathy Target Esterase遺伝子操作マウスの機能解析ー神経機能解析を中心に2019

    • Author(s)
      木村穰、阿部如子、本杉奈美、坂部貢、加藤明
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PPLN based frequency mixer for optical communication and sensing application2019

    • Author(s)
      M. Asobe, M. Katoh, K. Kugiyama, J. Tsuchiya and S.Katoh
    • Organizer
      Annual Congress of Smart Materials 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 広帯域中赤外DFG レーザを用いたガス吸収分光2019

    • Author(s)
      石川 大樹、内山 一樹、丸山 歩、遊部 雅生、鄭 和翊、山口 滋、平山 令明
    • Organizer
      レーザー学会学術講演会第39 回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Broadband mid-infrared spectroscopy for highly sensitive gas analysis2018

    • Author(s)
      K. Uchiyama, D. Ishikawa, A.yumu Maruyama, M. Asobe, K. Tei, S. Yamaguchi, and N. Hirayama
    • Organizer
      東京-モスクワ国際医学フォーラム 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PPLN based frequency mixer for optical signal processing and sensing application2018

    • Author(s)
      M. Asobe, M. Katoh, S. Punhavan, K. Uchiyama, D. Ishikawa
    • Organizer
      PIERS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ホルムアルデヒドガス曝露による反射性眼球運動への影響2018

    • Author(s)
      加藤 明、酒井 駿一、遊部 雅生、立崎 武弘、坂部 貢、木村 穣
    • Organizer
      ホルムアルデヒドガス曝露による反射性眼球運動への影響
    • Related Report
      2018 Annual Research Report
  • [Presentation] 3μm 帯レーザを用いたホルムアデヒド暴露条件モニタリング2018

    • Author(s)
      酒井 駿一,遊部 雅生,加藤 明, 内山 一樹,石川 大樹
    • Organizer
      ALPS 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Real time measurement of Folmaldehyde using 3μm difference frequency laser2017

    • Author(s)
      S. Sakai, M. Asobe, A. Katoh, A. Tokura
    • Organizer
      ALPS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 疑似位相整合LiNbO3導波路による広帯域中赤外レーザーの発生と分光応用2017

    • Author(s)
      遊部 雅生
    • Organizer
      月刊オプトロニクスセミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 前庭動眼反射の運動学習を引き起こす instructive signal2017

    • Author(s)
      加藤明
    • Organizer
      Life Engineering Symposium 2017
    • Related Report
      2017 Annual Research Report
  • [Book] ヒトの動きの神経科学シリーズ IV 運動学習の脳・神経科学―その基礎から臨床まで―2020

    • Author(s)
      加藤明
    • Total Pages
      210
    • Publisher
      市村出版
    • ISBN
      9784902109535
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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