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Study of nuclear reaction model for precise estimation of secondary exposure in carbon-ion therapy

Research Project

Project/Area Number 17H03522
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nuclear engineering
Research InstitutionKyushu University

Principal Investigator

Uozumi Yusuke  九州大学, 工学研究院, 准教授 (00232801)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords炭素線がん治療 / 原子核反応 / 二重微分断面積 / 原子核反応模型 / 重粒子治療 / 核反応断面積 / 核反応模型 / 重粒子線治療 / アルファ粒子 / 陽子 / 二次粒子 / 炭素イオン / 原子核反応断面積 / 粒子輸送計算
Outline of Final Research Achievements

In heavy ion radiotherapy, carbon ions are used to attack cancers in the patient's body. During carbon ions travel in the body, they can undergo nuclear reactions with elements of body. It is known that the most reaction products appear along the primary beam direction. Since there are concerns about long-term late effects due to low dose exposure, highly accurate prediction of dose is required, and it is necessary to measure double-differential cross-section (DDX) data and develop a theoretical model.
We developed the experimental equipment and measured DDXs. Experiments were carried out at the Heavy Ion Medical Accelerator In Chiba (HIMAC). The energy of emitted particles was measured with two types of crystal spectrometers. The notable point is that high-energy particles are observed at large angles. This fact suggests that the high-energy heavy-ions can have a long range over the beam diameter.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、炭素イオンによる多様な荷電粒子生成に関する原子核反応二重微分断面積データを測定する環境が整備されて、生体構成元素に対する二重微分断面積データを測定することが出来た。学術的には、新しいデータが得られ、その分析から未解決の問題が発見できたと期待される。理論的分析により炭素イオン反応に関する知見が深まり、高精度計算のための原子核反応模型の検討が大きく進展した。社会的には、大きな期待が持たれる小児がんの重粒子線がん治療において晩発効果の評価に要する低線量被ばく量を推定するための知見など基盤形成に向けてデータが整えられており、大きな意義がある。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (10 results)

All 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Joint Institute for Nuclear Research(ロシア連邦)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Joint Institute for Nuclear Research(ロシア連邦)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Charged Particle Emission Reactions by 100-MeV/u 12C Ions2020

    • Author(s)
      Kazuhito Yoshida, Yuji Yamaguchi, Ryota Imamura, Tatsuki Kakebayashi, Mizuki Yamada, Yuki Fukuda, Tomoe Katayama, Toshiya Sanami, Yosuke Iwamoto, Naruhiro Matsufuji, Yusuke Koba, Zviadi Tsamalaidze, Petr Evtoukhovitch, Yusuke Uozumi
    • Journal Title

      Proceedings of the 2019 Symposium on Nuclear Data

      Volume: 1 Pages: 137-142

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 重イオン治療に伴うフラグメント生成反応断面積の測定2018

    • Author(s)
      魚住裕介, 山口雄司, 藤井基晴, 吉田和人, 今村亮太, 福田雄基, 渡邊岳, 松藤成弘, 古場裕介, 岩元洋介
    • Journal Title

      バイオメディカル・ファジィ・システム学会誌

      Volume: 20 Pages: 9-14

    • NAID

      130007998335

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An intranuclear cascade model for inelastic scattering and breakup reactions involving deuterons and alpha particles2018

    • Author(s)
      Monira Jannatul Kobra, Gaku Watanabe, Yuji Yamaguchi, Yusuke Uozumi, Masahiro Nakano
    • Journal Title

      Journal of Nuclear Science and Technology

      Volume: 55 Issue: 2 Pages: 209-216

    • DOI

      10.1080/00223131.2017.1389313

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 重粒子線がん治療に関する炭素イオン反応二重微分断面積の測定2020

    • Author(s)
      掛林達樹, 魚住 裕介
    • Organizer
      バイオメディカル・ファジィ・システム学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 100MeV/u 12Cビーム入射荷電粒子生成反応の研究2019

    • Author(s)
      吉田 和人、藤井 基晴、山口 雄司、佐波 俊哉、松藤 成弘、古場 裕介、岩元 洋介、魚住 裕介
    • Organizer
      原子力学会2019年秋の大会, 2019.09
    • Related Report
      2019 Annual Research Report
  • [Presentation] Charged particle emission reactions induced by 100-MeV/u 12C ions2019

    • Author(s)
      Kazuhito YOSHIDA, Yuji YAMAGUCHI, Ryota IMAMURA, Tatsuki KAKEBAYASHI, Mizuki YAMADA, Yuki FUKUDA, Tomoe KATAYAMA, Toshiya SANAMI, Yosuke IWAMOTO, Naruhiro MATSUFUJI, Yusuke KOBA, Zviadi TSAMALAIDZE, Petr EVTOUKHOVITCH, Yusuke UOZUMI
    • Organizer
      2019 Symposium on Nuclear Data
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 数百 MeV/u α粒子入射における分解反応の研究(2)2018

    • Author(s)
      吉田和人,山口雄司,藤井基晴,佐波俊哉,松藤成弘,古場裕介,魚住裕介
    • Organizer
      原子力学会2018年秋の大会(岡山大学)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数百MeV/u α粒子入射における分解反応の研究2018

    • Author(s)
      山口 雄司、荒木 優佑、藤井 基晴、渡邉 岳、佐波 俊哉、松藤 成弘、古場 裕介、岩元 洋介、魚住 裕介
    • Organizer
      日本原子力学会 2018年春の年会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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