| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
The cerebrum of higher mammals exhibits folds (i.e. gyrus and sulcus) on its surface. The gyrus is thought to be important for the acquisition of higher brain functions, but the mechanisms of its formation still remain unclear. In this study, we analyzed the mechanisms of gyrus formation using gyrencephalic carnivore ferrets. We found that FGF signaling is essential for gyrus formation. Our findings suggest that FGF promotes the division of neural progenitors and gyrus formation. We investigated the cell biological processes that are important for gyrus formation and found that migration of neurons into the surface layers of the cerebral cortex is important. Furthermore, we found that sonic hedgehog signaling increases the number of progenitors by maintaining their immature state and as a result, promotes gyrus formation.
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