| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
This study was aimed at understanding molecular mechanisms underlying the meshwork-like migration of neural progenitors of the enteric nervous system (ENS). We used RET9-Y1015 mice whose ENS progenitors display impaired meshwork-like migration. Because these ENS progenitors are defective in PLCgamma signaling downstream of RET tyrosine kinase, we sought to identify the signaling molecules/pathways by performing phospho-proteomics analyses of ENS progenitors. With this method, we have discovered that PLCgamma signaling cascade and RET isoform-specific cooperates to achieve meshwork-like migration.
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