| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
This project is aimed at establishing ELISA quantification of CSF tau protein D279-4R, that is abundant in AD but not in PSP brains. This difference is now patented as a potential marker to distinguish AD and PSP. However, trials to establish an IgG clone with exclusive affinity to D279-4R were not successful but yielded a clone with affinity to both D279-4R and N279-4R. We are now characterizing this clone in comparison with RD4 with exclusive affinity to N279-4R. It is possible that this comparison will provide a tool to distinguish AD and PSP based on their difference in 4R tau species.
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