Elucidation of the neuronal mechanisms of plastic changes in the neural circuit for chronic pain-induced negative emotion such as depression and anxiety
| Project/Area Number |
17H03556
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 薬理学 / 神経科学 / 薬学 / 慢性痛 / 抑うつ / 不安 / 情動 / 分界条床核 |
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| Outline of Final Research Achievements |
The comorbidity of chronic pain and depression has long been recognized. Although dysfunction of the mesolimbic dopaminergic system has been implicated in both chronic pain and depression, the underlying mechanisms remain to be elucidated. In this study, we show that the inhibitory inputs to the neuronal pathway from the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area increase during chronic pain. This neuroplastic change is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST that leads to tonic suppression of the mesolimbic dopaminergic system, which may be involved in the depression-like symptoms under the chronic pain condition. These findings provide useful insights that may lead to the development of new treatments for chronic pain and depression.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性痛とうつ病は併発率が高いことが知られており、慢性痛による抑うつ状態とうつ病との間には共通の脳内メカニズムがあることが推測される。本研究成果は、慢性痛によるうつ病様症状に、脳内の分界条床核におけるCRF神経情報伝達活性化と、それによるドパミン神経活動抑制が関与することを明らかにしたものであり、慢性痛による抑うつや不安を改善するだけでなく、うつ病の治療にも役立つ新しい治療薬の開発に貢献することが期待される。
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Report
(4 results)
Research Products
(20 results)
