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Drug therapy of chronic phase of spinal cord injury; development of botanical drugs to improve muscle atrophy and axonal disruption

Research Project

Project/Area Number 17H03558
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionUniversity of Toyama

Principal Investigator

Tohda Chihiro  富山大学, 学術研究部薬学・和漢系, 教授 (10272931)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsニクジュヨウ / 脊髄損傷慢性期 / 軸索修復 / acteoside / PKM2 / ロコモティブシンドローム / 頚椎症性脊髄症 / Acteoside / 生薬医薬品 / 脊髄損傷 / 筋萎縮 / 筋委縮 / ニクジュウヨウ / 精髄損傷 / 骨格筋萎縮 / myokine
Outline of Final Research Achievements

Oral administration of Cistanche tubulosa extract (CT extract) improved motor function and muscle mass in chronic phase of spinal cord injured mice. Oral administration of CT extract also improved walking ability of cast-immobilization-evoked muscle atrophy mice. Acteoside, an active compound in CT extract, transferred to the skeletal muscle and the central nervous system after oral administration of CT extract. When acteoside stimulated skeletal muscle, PKM2 was secreted from skeletal muscles as a myokine. PKM2 traveled to the brain and stimulated VCP on neurons, resulting axonal extension. On the other hand, acteoside also directly activated axonal extension via Akt and MEK in the brain. In a clinical study, locomotive syndrome subjects showed improved performance in walking by CT extract intake.

Academic Significance and Societal Importance of the Research Achievements

慢性期の脊髄損傷の機能回復には、断裂した軸索の伸展だけでなく、筋萎縮を改善させることが重要である。ニクジュヨウエキスはまさにこの作用を有し、難治性の脊髄損傷慢性期での機能改善が可能な薬物であることが示された。また本研究は、PKM2がmyokineであること、神経細胞に作用して軸索伸展を促進することを発見した。Myokineが神経細胞に直接作用することを証明した初めての例でもある。
ニクジュヨウエキスの運動機能改善効果に着目し、ロコモティブシンドロームへの有効性と安全性をヒトで示した。この知見は、同疾患に対する医薬品開発の礎になるとともに、現在進行中の、脊髄症に対する臨床研究につながった。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (148 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (38 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 37 results,  Open Access: 30 results,  Acknowledgement Compliant: 1 results) Presentation (100 results) (of which Int'l Joint Research: 16 results,  Invited: 6 results) Book (1 results) Patent(Industrial Property Rights) (9 results) (of which Overseas: 2 results)

  • [Journal Article] A Novel Heptapeptide, GPPGPAG Transfers to the Brain, and Ameliorates Memory Dysfunction and Dendritic Atrophy in Alzheimer’s Disease Model Mice2021

    • Author(s)
      Tohda Chihiro、Kogure Chisato、Nomoto Kaori、Toledo Andreia de、Yang Ximeng、Hirano Eiichi
    • Journal Title

      Frontiers in Pharmacology

      Volume: 12 Pages: 680652-680652

    • DOI

      10.3389/fphar.2021.680652

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of <i>Trigonella foenum-graecum</i> seeds extract on Alzheimer’s disease transgenic model mouse and its potential active compound transferred to the brain2021

    • Author(s)
      Mai M. Farid、長瀬 綸沙、楊 熙蒙、野本 かおり、久保山 友晴、稲田 祐奈、東田 千尋
    • Journal Title

      Japanese Journal of Food Chemistry and Safety

      Volume: 28 Issue: 2 Pages: 63-70

    • DOI

      10.18891/jjfcs.28.2_63

    • NAID

      130008080445

    • ISSN
      1341-2094, 2189-6445
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β2021

    • Author(s)
      de Toledo Andreia、Nomoto Kaori、Hirano Eiichi、Tohda Chihiro
    • Journal Title

      Nutrients

      Volume: 13 Issue: 5 Pages: 1672-1672

    • DOI

      10.3390/nu13051672

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intrathecal Infusion of Diosgenin during the Chronic Phase of Spinal Cord Injury Ameliorates Motor Function and Axonal Density2021

    • Author(s)
      Nakano Aoi、Yang Ximeng、Kuboyama Tomoharu、Inada Yuna、Tohda Chihiro
    • Journal Title

      Neurochemical Journal

      Volume: 15 Issue: 4 Pages: 454-461

    • DOI

      10.1134/s1819712421040085

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skeletal muscle atrophy‐induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease2021

    • Author(s)
      Nagase Tsukasa、Tohda Chihiro
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 12 Issue: 6 Pages: 2199-2210

    • DOI

      10.1002/jcsm.12830

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ジオスゲニンの認知機能改善効果.2021

    • Author(s)
      東田 千尋、楊 熙蒙、稲田 祐奈.
    • Journal Title

      Functional Food(2021) 40号

      Volume: 15(1) Pages: 10-16

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Cistanche tubulosa Wight Extract on Locomotive Syndrome: A Placebo-Controlled, Randomized, Double-Blind Study2021

    • Author(s)
      Inada Yuna、Tohda Chihiro、Yang Ximeng
    • Journal Title

      Nutrients

      Volume: 13 Issue: 1 Pages: 264-264

    • DOI

      10.3390/nu13010264

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix2021

    • Author(s)
      Kuboyama Tomoharu、Kominato Seiya、Nagumo Misaki、Tohda Chihiro
    • Journal Title

      Phytomedicine

      Volume: 82 Pages: 153452-153452

    • DOI

      10.1016/j.phymed.2020.153452

    • NAID

      130008001435

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recovery of motor function of chronic spinal cord injury by extracellular pyruvate kinase isoform M2 and the underlying mechanism2020

    • Author(s)
      Kikuchi Takahiro、Tohda Chihiro、Suyama Masato
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 19475-19475

    • DOI

      10.1038/s41598-020-76629-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts2020

    • Author(s)
      Yang Ximeng、Nomoto Kaori、Tohda Chihiro
    • Journal Title

      Journal of Natural Medicines

      Volume: 75 Issue: 1 Pages: 207-216

    • DOI

      10.1007/s11418-020-01451-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule2020

    • Author(s)
      Farid Mai M.、Yang Ximeng、Kuboyama Tomoharu、Tohda Chihiro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 16424-16424

    • DOI

      10.1038/s41598-020-73514-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GRP78-Mediated Signaling Contributes to Axonal Growth Resulting in Motor Function Recovery in Spinal Cord-Injured Mice2020

    • Author(s)
      Tanie Yoshitaka、Kuboyama Tomoharu、Tohda Chihiro
    • Journal Title

      Frontiers in Pharmacology

      Volume: 11 Pages: 789-789

    • DOI

      10.3389/fphar.2020.00789

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 局外生規2018に新規収載された単味生薬エキスの確認試験及び定量法の設定について.2020

    • Author(s)
      内山奈穂子,増本直子,丸山卓郎,合田幸広,ほか
    • Journal Title

      生薬学雑誌

      Volume: 74(1) Pages: 20-34

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transported amount of diosgenin to the brain is differed by a solvent fat.2020

    • Author(s)
      Tohda C, Yang X, Nomoto K.
    • Journal Title

      日本食品化学学会誌 Japanese Journal of Food Chemistry and Safety

      Volume: 27(2) Pages: 102-105

    • NAID

      130007893451

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ジオスゲニンによる認知機能の向上2020

    • Author(s)
      東田千尋
    • Journal Title

      Food STYLE 21

      Volume: 24(2) Pages: 34-37

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知機能を制御するファイトケミカル2020

    • Author(s)
      東田千尋、楊熙蒙
    • Journal Title

      医学のあゆみ

      Volume: 270(8) Pages: 605-609

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease2020

    • Author(s)
      Kuboyama Tomoharu、Yang Ximeng、Tohda Chihiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 13 Pages: 4665-4665

    • DOI

      10.3390/ijms21134665

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults2020

    • Author(s)
      Tohda Chihiro、Matsui Mie、Inada Yuna、Yang Ximeng、Kuboyama Tomoharu、Kimbara Yoshiyuki、Watari Hidetoshi
    • Journal Title

      Nutrients

      Volume: 12 Issue: 2 Pages: 303-303

    • DOI

      10.3390/nu12020303

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cistanche tubulosa (Schenk) Wight Extract Enhances Hindlimb Performance and Attenuates Myosin Heavy Chain IId/IIx Expression in Cast-Immobilized Mice2019

    • Author(s)
      Kimbara Yoshiyuki、Shimada Yutaka、Kuboyama Tomoharu、Tohda Chihiro
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2019 Pages: 1-10

    • DOI

      10.1155/2019/9283171

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Porcine placental extract facilitates memory and learning in aged mice2019

    • Author(s)
      Yamauchi Akihiro、Tone Takahiro、Sugimoto Koji、Seok Lim Hong、Kaku Taiichi、Tohda Chihiro、Shindo Takayuki、Tamada Koji、Mizukami Yoichi、Hirano Eiichi
    • Journal Title

      Food Science & Nutrition

      Volume: 7 Issue: 9 Pages: 2995-3005

    • DOI

      10.1002/fsn3.1156

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury2019

    • Author(s)
      Tohda Chihiro、Tanabe Norio、Kuboyama Tomoharu
    • Journal Title

      Neural Regeneration Research

      Volume: 14 Issue: 11 Pages: 1961-1961

    • DOI

      10.4103/1673-5374.259625

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kihito, a Traditional Japanese Kampo Medicine, Improves Cognitive Function in Alzheimer’s Disease Patients2019

    • Author(s)
      Watari Hidetoshi、Shimada Yutaka、Matsui Mie、Tohda Chihiro
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2019 Pages: 1-7

    • DOI

      10.1155/2019/4086749

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain2019

    • Author(s)
      Yamauchi Yui、Ge Yue-Wei、Yoshimatsu Kayo、Komatsu Katsuko、Kuboyama Tomoharu、Yang Ximeng、Tohda Chihiro
    • Journal Title

      Nutrients

      Volume: 11 Issue: 5 Pages: 1142-1142

    • DOI

      10.3390/nu11051142

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression2019

    • Author(s)
      Yang Zhiyou、Kuboyama Tomoharu、Tohda Chihiro
    • Journal Title

      Phytotherapy Research

      Volume: in press Issue: 4 Pages: 1-8

    • DOI

      10.1002/ptr.6305

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury.2019

    • Author(s)
      Kodani A, Kikuchi T, Tohda C.
    • Journal Title

      J Neurotrauma.

      Volume: 35 Issue: 12 Pages: 1-14

    • DOI

      10.1089/neu.2018.6000

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Matrine promotes neural circuit remodeling to regulate motor function in a chronic model of spinal cord injury.2019

    • Author(s)
      Tanabe Norio, Kuboyama Tomoharu, Tohda Chihiro.
    • Journal Title

      Neural Regeneration Research

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice.2018

    • Author(s)
      Tanabe N, Kuboyama T, Tohda C.
    • Journal Title

      Front Pharmacol.

      Volume: 9 Pages: 446-446

    • DOI

      10.3389/fphar.2018.00446

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70).2018

    • Author(s)
      Yang X, Tohda C.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 11707-11707

    • DOI

      10.1038/s41598-018-30102-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 和漢薬創薬を目指した基礎研究と臨床研究.2018

    • Author(s)
      東田千尋、久保山友晴、楊熙蒙、
    • Journal Title

      生体の科学

      Volume: 69 Pages: 354-357

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease2018

    • Author(s)
      Yang X., Tohda C.
    • Journal Title

      Front Pharmacol.

      Volume: 9 Pages: 48-48

    • DOI

      10.3389/fphar.2018.00048

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis. Exp. Neurol.2018

    • Author(s)
      Sakamoto I, Ueyama T, Hayashibe M, Nakamura T, Mohri H, Kiyonari H, Shigyo M, Tohda C, Saito N.
    • Journal Title

      Exp. Neurol.

      Volume: 302 Pages: 57-67

    • DOI

      10.1016/j.expneurol.2017.12.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular cathepsin L stimulates axonal growth in neurons.2017

    • Author(s)
      Tohda C, Tohda M.
    • Journal Title

      BMC Research Note

      Volume: 10 Issue: 1 Pages: 613-613

    • DOI

      10.1186/s13104-017-2940-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polygalae Radix extract prevents axonal degeneration and memory deficits in a transgenic mouse model of Alzheimer’s disease2017

    • Author(s)
      Kuboyama T., Hirotsu K., Arai T., Yamasaki H., Tohda C.
    • Journal Title

      Front Pharmacol.

      Volume: 8 Pages: 805-805

    • DOI

      10.3389/fphar.2017.00805

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults.2017

    • Author(s)
      Tohda C., Yang X., Matsui M., Inada Y., Kadomoto E., Nakada S., Watari H., Shibahara N.
    • Journal Title

      Nutrients

      Volume: 9 Issue: 10 Pages: 1160-1160

    • DOI

      10.3390/nu9101160

    • NAID

      120006375104

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular Cytosolic Aspartate Aminotransferase Promotes Axonal Growth and Object Recognition Memory.2017

    • Author(s)
      Kobayashi R., Tohda C.
    • Journal Title

      Neurochem Res.

      Volume: 42 Issue: 12 Pages: 3465-3473

    • DOI

      10.1007/s11064-017-2394-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human placenta extract ameliorates memory dysfunction and dendritic atrophy in a 5XFAD mouse model of Alzheimer’s disease.2017

    • Author(s)
      Kogure C, Tohda C.
    • Journal Title

      Traditional & Kampo Medicine

      Volume: 4(2) Issue: 2 Pages: 94-104

    • DOI

      10.1002/tkm2.1075

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A systematic strategy for discovering a therapeutic drug for Alzheimer’s disease and its target molecule2017

    • Author(s)
      Yang Z., Kuboyama T., Tohda C.
    • Journal Title

      Frontiers in Pharmacology

      Volume: 8 Pages: 340-340

    • DOI

      10.3389/fphar.2017.00340

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury2017

    • Author(s)
      Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Kuboyama T, Uebi T, Hamada T, Gutmann DH, Aiba A, Kohmura E, Tohda C, Saito N
    • Journal Title

      J Biol Chem

      Volume: 292 Issue: 4 Pages: 1240-1250

    • DOI

      10.1074/jbc.m116.748871

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Diosgenin promotes long-distance axonal regeneration in the brain and recovers memory deficits in a mouse model of Alzheimer’s disease.2022

    • Author(s)
      Ximeng Yang, Chihiro Tohda.
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effects of sibiricose A5, a constituent of Polygalae Radix, on recovery of memory in the mouse model of Alzheimer’s disease.2022

    • Author(s)
      Tomoharu Kuboyama, Yuta Arake, Misaki Nagumo, Seiya Kominato, Chihiro Tohda.
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 局外生規2022に新規収載予定の単味生薬エキスについて2022

    • Author(s)
      内山奈穂子, 新井玲子,田中誠司, 丸山卓郎, 袴塚高志, 伊藤雅文, 若林健一, 武田修己, 小栗志織, 佐々木隆宏, 岡秀樹, 白鳥誠, 秋田幸子, 植村清美, 浅野年紀, 日向野太郎, 杉本智潮, 近藤誠三, 吉田雅昭, 西川加奈子, 山田修嗣, 山本豊, 玉木智生, 木内文之, 東田千尋, 竹林憲司, 小笠原勝, 中村高敏, ほか
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Diosgeninがアルツハイマー病モデルマウスの脳内で軸索を再伸長させる分子メカニズムの解明2022

    • Author(s)
      楊熙蒙、東田千尋..
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Diosgeninはアルツハイマー病モデルマウスの脳内において軸索を再伸長させ記憶障害を改善する。2021

    • Author(s)
      楊熙蒙、東田千尋、
    • Organizer
      日本薬学会第141年会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] Recovery of memory deficits by overexpression of Shati/Nat8l in the hippocampus in a mouse model of Alzheimer’s disease.2021

    • Author(s)
      Chino K, Izuo N, Kuboyama T, Tohda C, Nitta A.
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Diosgeninによって軸索が再伸長し記憶が改善する分子メカニズムの解明.)2021

    • Author(s)
      楊熙蒙、東田千尋.
    • Organizer
      第2回和漢医薬学会若手研究者フォーラム~芽吹け!若手の和漢薬研究~
    • Related Report
      2021 Annual Research Report
  • [Presentation] ニクジュヨウエキスによる後縦靭帯骨化症の運動機能改善作用の検討.2021

    • Author(s)
      須山真聡、楊熙蒙、野本かおり、東田千尋.
    • Organizer
      第38回和漢医薬学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ロコモティブシンドロームに対するニクジュヨウエキスの効果.2021

    • Author(s)
      稲田祐奈、楊熙蒙、東田千尋.
    • Organizer
      第38回和漢医薬学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 運動神経から骨格筋への軸索投射を促進する和漢薬の探索2021

    • Author(s)
      楊熙蒙、近藤麻布、東田千尋.
    • Organizer
      第38回和漢医薬学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ニクジュヨウエキスによる慢性期脊髄損傷の運動機能改善とそのメカニズム2021

    • Author(s)
      東田 千尋、小谷 篤、須山 真聡、野本かおり.
    • Organizer
      第38回和漢医薬学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 遠志成分sibiricose A5による抗アルツハイマー病作用.2021

    • Author(s)
      久保山友晴、荒毛優太、南雲美咲、小湊誠也、東田千尋.
    • Organizer
      第38回和漢医薬学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer’s disease.2021

    • Author(s)
      Nagase T, Tohda C.
    • Organizer
      The 6th Toyama-Basel Joint Symposium 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diosgenin含有山薬エキスによる認知機能向上作用:マウスおよび健常人での検討.2021

    • Author(s)
      東田 千尋,楊 熙蒙、稲田 祐奈.
    • Organizer
      日本生薬学会第67回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effects of Cistanche tubulosa extract on motor function in ossification of posterior longitudinal ligment model mice.2021

    • Author(s)
      Suyama M, Yang X, Nomoto K, Tohda C.
    • Organizer
      第64回日本神経化学学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Investigation of drug effects on optic nerve growth in a mouse model of normal tension glaucoma2021

    • Author(s)
      Shibue S, Tohda C. .
    • Organizer
      第64回日本神経化学学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Skeletal muscle atrophy increases hemopexin secretion and accelerates the onset of cognitive impairment in Alzheimer’s disease.2021

    • Author(s)
      Nagase T, Tohda C.
    • Organizer
      第64回日本神経化学学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Molecular mechanisms for long-distance axonal regeneration in the brain of Alzheimer’s disease model mouse.2021

    • Author(s)
      Yang X, Tohda C.
    • Organizer
      第64回日本神経化学学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Diosgenin-rich yam extract enhances cognitive function: a placebo-controlled, randomized, double-blind, crossover study of healthy adults.2021

    • Author(s)
      Tohda C, Inada Y, Yang X.
    • Organizer
      第64回日本神経化学学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Diosgeninによるアルツハイマー病脳内での軸索修復作用と臨床研究への展開.2021

    • Author(s)
      東田 千尋、楊 熙蒙、稲田祐奈.
    • Organizer
      第94回日本生化学大会 シンポジウム「健康長寿社会に向けた和漢薬研究の新展開」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Diosgenin is a candidate drug for stimulating axonal regeneration in the brain and recovering memory deficits in Alzheimer’s disease.2021

    • Author(s)
      Ximeng Yang, Chihiro Tohda.
    • Organizer
      第16回国際伝統医薬シンポジウム・富山2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Skeletal muscle atrophy accelerates onset of cognitive impairment in Alzheimer’s disease via hemopexin delivery from muscle to the brain.2021

    • Author(s)
      Nagase T, Tohda C.
    • Organizer
      ISN-APSN School, Behavioral Analysis Models for Neurocjemical Research.
    • Related Report
      2021 Annual Research Report
  • [Presentation] Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix 遠志によるマイクログリアM2化を介した脊髄損傷からの回復.2021

    • Author(s)
      久保山友晴、小湊誠也、南雲美咲、東田千尋.
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Recovery of memory deficits by overexpression of Shati/Nat8l in the hippocampus in a mouse model of Alzheimer’s disease2021

    • Author(s)
      Chino K, Izuo N, Kuboyama T, Tohda C, Nitta A. .
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 海馬でのShati/Nat8lの過剰発現はアルツハイマー病モデルマウスの認知機能低下を改善する.2020

    • Author(s)
      千野翔、泉尾直孝、久保山友晴、東田千尋、新田淳美.
    • Organizer
      富山薬学研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新規マイオカインPKM2の慢性期脊髄損傷改善作用と分泌様式の検討.2020

    • Author(s)
      須山真聡、東田千尋.
    • Organizer
      富山薬学研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 緑内障における視神経の保護および修復に対するdiosgeninの作用.2020

    • Author(s)
      真継理子、楊熙蒙、東田千尋.
    • Organizer
      富山薬学研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 認知症発症を加速する新規骨格筋分泌因子.2020

    • Author(s)
      長瀬綸沙、東田千尋.
    • Organizer
      富山薬学研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脊髄損傷慢性期の機能回復に有効な薬物と分子2020

    • Author(s)
      東田千尋
    • Organizer
      第63回 日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Diosgeninがアルツハイマー病モデルマウスの脳内において軸索を再伸長させる分子メカニズムの解明2020

    • Author(s)
      楊熙蒙、東田千尋.
    • Organizer
      第63回 日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 認知症発症を加速する骨格筋分泌性因子2020

    • Author(s)
      長瀬綸沙,東田千尋.
    • Organizer
      第63回 日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新規マイオカインのPKM2 は慢性期脊髄損傷の運動機能を回復する2020

    • Author(s)
      須山真聡、菊池高広、中野葵、東田千尋.
    • Organizer
      第63回 日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ジオスゲニンによってアルツハイマー病の記憶障害が回復することに関与する、脳内の内分泌的作用の探索2020

    • Author(s)
      真継理子,楊熙蒙、中野葵,東田千尋.
    • Organizer
      第63回 日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アミロイドβによる軸索変性に着目したアルツハイマー病予防・治療法の開発.2020

    • Author(s)
      久保山友晴, 楊熙蒙、東田千尋.
    • Organizer
      第37回和漢医薬学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] エゾウコギ葉エキスと骨砕補エキスの合剤による認知機能とストレス抵抗性に対するランダム化二重盲検試験2020

    • Author(s)
      東田千尋、松井三枝、稲田祐奈、楊熙蒙、久保山友晴、金原嘉之、渡り英俊..
    • Organizer
      第37回和漢医薬学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Diosgeninはアルツハイマー病の脳内において軸索を正しく再伸長させる.2020

    • Author(s)
      楊熙蒙、東田千尋
    • Organizer
      第37回和漢医薬学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Trigonelline: A promising compound for the treatment of Alzheimer’s Disease2020

    • Author(s)
      Farid M. Mai, Yang X, Kuboyama T, Tohda C.
    • Organizer
      International Conference on Medicinal Plants, Pharmacognosy, Phytochemistry and Natural Products
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HDAC3 inhibition ameliorates dystrophic axons and memory function via M2 microglia in a transgenic mouse model of Alzheimer’s disease. アルツハイマー病モデルマウスにおいて、HDAC3阻害はマイクログリアのM2化を介して変性軸索を正常化させ、記憶回復作用を示す。2020

    • Author(s)
      Kuboyama T, Tohda C.
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] HDAC3 inhibition ameliorates dystrophic axons and memory function via M2 microglia in a transgenic mouse model of Alzheimer’s disease.2020

    • Author(s)
      Kuboyama T, Tohda C.
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Axonal growth may lead to recovery from anxiety.2019

    • Author(s)
      Kuboyama T, Iseki R, Hosokawa H, Tohda C.
    • Organizer
      Toyama Forum for Academic Summit on “Dynamic Brain”
    • Related Report
      2019 Annual Research Report
  • [Presentation] Trigonelline: A promising compound for the treatment of Alzheimer’s Disease.2019

    • Author(s)
      Farid M. Mai, Yang X, Kuboyama T, Tohda C.
    • Organizer
      Toyama Forum for Academic Summit on “Dynamic Brain”
    • Related Report
      2019 Annual Research Report
  • [Presentation] Diosgenin prootes proper axonal regrowth in the brain and recovers memory deficits in a mouse model of Alzheimer’s disease.2019

    • Author(s)
      Yang X, Tohda C.
    • Organizer
      Toyama Forum for Academic Summit on “Dynamic Brain”
    • Related Report
      2019 Annual Research Report
  • [Presentation] 認知症発症を加速する骨格筋分泌性因子2019

    • Author(s)
      長瀬綸沙、東田千尋.
    • Organizer
      本薬学会北陸支部第131回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] New myokine-mediated improvement of motor function and muscle atrophy in chronic spinal cord injury.2019

    • Author(s)
      Tohda C, Kodani A, Kikuchi T
    • Organizer
      Society for Neuroscience 49th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A new unbeneficial myokine secreted from atrophied skeletal muscle accelerates the onset of Alzheimer’s disease.2019

    • Author(s)
      Nagase T, Tohda C.
    • Organizer
      Society for Neuroscience 49th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diosgenin improve memory deficits in a mouse model of Alzheimer’s disease by promoting axonal regrowth in the brain.2019

    • Author(s)
      Yang X, Tohda C.
    • Organizer
      Society for Neuroscience 49th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HDAC3 inhibition ameliorates memory function via M2 microglia in a transgenic mouse model of Alzheimer’s disease.2019

    • Author(s)
      Kuboyama T, Tohda C.
    • Organizer
      Society for Neuroscience 49th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Naringenin promotes aβ clearance and ameliorates cognitive deficiency in Alzheimer’s disease and underlying mechanisms.2019

    • Author(s)
      Yang Z, Kuboyama T, Tohda C.
    • Organizer
      Society for Neuroscience 49th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 和漢薬創薬に向けた基礎研究と臨床研究2019

    • Author(s)
      東田千尋
    • Organizer
      第 36 回 和漢医薬学会学術大会 シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 植物性医薬品の開発と薬用植物供給に向けた新たなアプローチ2019

    • Author(s)
      小松かつ子、東田千尋
    • Organizer
      第 36 回 和漢医薬学会学術大会 シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 山薬エキスによる記憶力亢進作用の検討2019

    • Author(s)
      楊 熙蒙,東田 千尋
    • Organizer
      第 36 回 和漢医薬学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 苦参成分matrineは神経伝導路再構築により慢性期脊髄損傷マウスの運動機能を回復させる2019

    • Author(s)
      久保山友晴、田辺紀生、東田千尋
    • Organizer
      第 36 回 和漢医薬学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Diosgenin elicits axonal regrowth in the brain and improves memory deficits in a mouse model of Alzheimer’s disease.2019

    • Author(s)
      Yang X, Tohda C.
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of diosgenin on motor function and axonal outgrowth in chronic phase of spinal cord injury.2019

    • Author(s)
      Nakano A, Tohda C.
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] HDAC3 inhibition ameliorates memory function via M2 skewing of microglia in a transgenic mouse model of Alzheimer’s disease.2019

    • Author(s)
      Kuboyama T, Tohda C.
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Acteoside improves muscle atrophy and motor function by inducing new myokine secretion in chronic spinal cord injury.2019

    • Author(s)
      Tohda C, Kodani A, Kikuchi T.
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] The molecular mechanism in the brain, as a New myokine PKM2 in chronic spinal cord injury.2019

    • Author(s)
      Kikuchi T, Kodani A, Tohda C.
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neuroleukin enhances neuroleukin secretion from astrocytes and promotes axonal growth.2019

    • Author(s)
      Tanie Y, Tanabe N, Kuboyama T, Tohda C.
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 認知機能改善を目指した和漢薬からのアプローチ.2019

    • Author(s)
      東田千尋
    • Organizer
      国立大学附置研究所・センター会議 第2部会シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 和漢薬を基盤とした神経疾患治療薬開発.2019

    • Author(s)
      東田千尋
    • Organizer
      日本学術会議 in 富山「富山から発信する学術研究とSDGs対応」
    • Related Report
      2019 Annual Research Report
  • [Presentation] 和漢薬研究による認知症治療への挑戦(Development of promising therapeutic drugs for dementia)2019

    • Author(s)
      東田千尋
    • Organizer
      富山・ミャンマー・医薬品・プライマリーヘルスケアシンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経疾患の治療戦略創出に向けた和漢薬研究.2018

    • Author(s)
      東田千尋、楊熙蒙、
    • Organizer
      第65回日本動物学会総会 企画シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Diosgenin-induced reduction of HSC70 results in axonal regeneration. and improvement of memory function in a mouse model of Alzheimer’s disease2018

    • Author(s)
      Yang Ximeng, Tohda Chihiro.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acteoside-induced PKM2 secretion from skeletal muscle is associated with functional recovery of chronic spinal cord injury.2018

    • Author(s)
      Tohda Chihiro., Kodani Atsushi.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polygalae Radix extract prevents axonal degeneration and memory deficits in a transgenic mouse model of Alzheimer’s disease.2018

    • Author(s)
      Kuboyama Tomoharu., Tohda Chihiro.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルツハイマー病の認知機能に及ぼす帰脾湯の効果の研究.2018

    • Author(s)
      渡り英俊 嶋田豊 東田千尋、
    • Organizer
      第 35 回 和漢医薬学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Diosgeninによる脳内の軸索修復を介したアルツハイマー病の記憶回復作用.2018

    • Author(s)
      楊熙蒙、東田千尋、
    • Organizer
      第 35 回 和漢医薬学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 日本発の植物性医薬品開発に向けたアカデミアでの研究.2018

    • Author(s)
      東田千尋、
    • Organizer
      第 35 回 和漢医薬学会学術大会第 35 回 和漢医薬学会学術大会 公募シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マイクログリアのM2/M1比を増加させる遠志による脊髄損傷の改善2018

    • Author(s)
      小湊誠也、久保山友晴、東田千尋、
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アクテオサイドによる骨格筋活性化を介した慢性期脊髄損傷の改善.2018

    • Author(s)
      菊池高弘、小谷篤、東田千尋、
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脊髄損傷マウスの運動機能回復と軸索修復へのジオスゲニンの作用.2018

    • Author(s)
      中野葵、東田千尋、
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] エゾウコギ葉水エキス経口投与による記憶向上作用と脳に移行する活性成分の同定2018

    • Author(s)
      山内唯、葛躍偉、吉松嘉代、小松かつ子、東田千尋、.
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞外ニューロロイキンはアストロサイトからのニューロロイキン分泌を促し、神経細胞の軸索伸展を促す.2018

    • Author(s)
      谷江良崇、田辺紀生、久保山友晴、東田千尋、
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DiosgeninによるHSC70の減少はアルツハイマー病における軸索萎縮と記憶障害を改善する.2018

    • Author(s)
      楊熙蒙、東田千尋、
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アルツハイマー病モデルマウスにおいてHDAC3阻害はマイクログリアの表現型制御を介して記憶を改善させる.2018

    • Author(s)
      久保山友晴、東田千尋、
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ジオスゲニン高濃度含有ヤマイモエキスによる健常人の認知機能向上:ランダム化二重盲検プラセボ対照クロスオーバー試験による検討.2018

    • Author(s)
      東田千尋、楊熙蒙、稲田祐奈、松井三枝、
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Promising Therapeutic Drugs for Neurodegenerative Diseases.2018

    • Author(s)
      Chihiro Tohda.
    • Organizer
      4th 2018 Joint Symposium between Institute of Natural Medicine at University of Toyama and Natural Products Research Institute at Seoul National University.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アルカニンのアミロイドβ凝集・神経細胞毒性に対する作用.2018

    • Author(s)
      細井 徹、今田 理裕、俵 明里、矢澤 恭介、東田 千尋 、野村 靖幸、小澤 光一郎、
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アルツハイマー病モデルマウスにおいてHDAC3阻害はマイクログリアのM2化を介して記憶を改善させる.2018

    • Author(s)
      久保山友晴、東田千尋、
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 局外生規2018 に新規収載された単味生薬エキス等について.2018

    • Author(s)
      内山奈穂子, 増本直子, 丸山卓郎,ほか
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アルカニンのアミロイドβ凝集に対する抑制作用の検討.2018

    • Author(s)
      細井 徹、今田 理裕、俵 明里、矢澤 恭介、東田 千尋、野村 靖幸、小澤 光一郎、
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of promising therapeutic drugs for cognitive function.2018

    • Author(s)
      Chihiro Tohda,
    • Organizer
      北京大学薬学院富山大学和漢医薬学総合研究所学術交流会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 遠志エキスはアルツハイマー病モデルマウスの軸索変性及び記憶障害の誘発を予防する.2018

    • Author(s)
      久保山友晴、東田千尋、
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cytosolic aspartate aminotransferase, a direct binding protein of kamikihito, regulates axon growth.2017

    • Author(s)
      Watari H. Shimada Y, Tohda C.
    • Organizer
      The 6th Joint Symposium -WHO CCs for Traditional Medicine in Korea & Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diosgenin improves memory function in a mouse model of Alzheimer’s disease via the reduction of HSC70.2017

    • Author(s)
      Yang X., Tohda C.
    • Organizer
      第40回日本神経科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chronic spinal cord injury repair mediated by skeletal muscle-secreted new myokine.2017

    • Author(s)
      Kodani A., Tanabe N., Tohda C.
    • Organizer
      第40回日本神経科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Neuroleukin enhanced axonal growth in neurons and self secretion from astrocytes.2017

    • Author(s)
      Tohda C., Tanie Y., Tanabe N., Kuboyama T.
    • Organizer
      第40回日本神経科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Polygalae Radix extract induces M2 microglia predominance and improves spinal cord injury.2017

    • Author(s)
      Kominato S., Kuboyama T., Tohda C.
    • Organizer
      第40回日本神経科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel pharmacological effects of matrine: Axonal growth activity overcoming an inhibitory environment and improvement of spinal cord injury.2017

    • Author(s)
      Tanabe N., Kuboyama T., Tohda C.
    • Organizer
      第40回日本神経科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エゾウコギ葉水エキスによる記憶向上作用と活性成分の検討2017

    • Author(s)
      山内唯、葛躍偉、吉松嘉代、小松かつ子、東田千尋、
    • Organizer
      第34回和漢医薬学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 芍薬エキスおよび芍薬由来化合物の筋細胞に対する効果.2017

    • Author(s)
      金原嘉之、嶋田豊、東田千尋、
    • Organizer
      第34回和漢医薬学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遠志によるアルツハイマー病予防作用.2017

    • Author(s)
      久保山友晴、弘津圭祐、荒井哲也、山﨑寛生、和田篤敬、東田千尋.
    • Organizer
      第34回和漢医薬学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルツハイマー病の記憶障害を改善する帰脾湯・加味帰脾湯.2017

    • Author(s)
      東田 千尋.
    • Organizer
      第34回和漢医薬学会学術大会 大会特別企画 「日本東洋医学会との合同シンポジウム」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Polygalae Radix extract induces M2 microglia and improves the locomotor function in the spinal cord injury.2017

    • Author(s)
      Kominato S, Kuboyama T, Tohda C.
    • Organizer
      International Symposium on Scientific Research of Traditional Medicine.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acteoside improves chronic spinal cord injury via a skeletal muscle-secreted new myokine.2017

    • Author(s)
      Kodani A., Tohda C.
    • Organizer
      Society for Neuroscience 47th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diosgenin restores axonal degeneration via the reduction of HSC70, resulting in improvement of memory function in Alzheimer’s disease.2017

    • Author(s)
      Yang X., Tohda C.
    • Organizer
      Society for Neuroscience 47th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cognitive enhancement by diosgenin treatment.2017

    • Author(s)
      Tohda C., Yang X.
    • Organizer
      Society for Neuroscience 47th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規マイオカインを介したアクテオシドによる慢性期脊髄損傷改善作用の研究.2017

    • Author(s)
      小谷篤、東田千尋、
    • Organizer
      日本薬学会北陸支部第129回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] DiosgeninによるHSC70の減少はアルツハイマー病の軸索萎縮と記憶障害を改善する2017

    • Author(s)
      楊熙蒙、東田千尋、.
    • Organizer
      日本薬学会北陸支部第129回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脊髄損傷の運動麻痺および骨格筋萎縮を改善する薬物の研究.2017

    • Author(s)
      東田千尋、
    • Organizer
      平成29年度中部地区医療・バイオ系シーズ発表会
    • Related Report
      2017 Annual Research Report
  • [Book] 認知症に有効な漢方薬・生薬.漢方薬・生薬薬剤師講座テキスト第5版2021

    • Author(s)
      東田千尋
    • Total Pages
      12
    • Publisher
      財団法人 日本薬剤師研修センター
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経変性疾患の予防、治療及び/又は改善剤2021

    • Inventor(s)
      東田千尋、長瀬綸沙
    • Industrial Property Rights Holder
      国立大学法人富山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-077150
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] ユビキチン―プロテアソーム系の活性化剤、およびその利用2020

    • Inventor(s)
      甲斐田大輔、東田千尋、伊野部智由、
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-114185
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 軸索伸展剤2020

    • Inventor(s)
      東田千尋、楊熙蒙
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-139980
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] ペリオスチン及びPKM2の分泌促進剤 PCT出願:PCT/JP2018/25119 出願日 :平成30年7月2日 出願人 :国立大学法人富山大学2018

    • Inventor(s)
      東田千尋、小谷篤
    • Industrial Property Rights Holder
      東田千尋、小谷篤
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 記憶改善用ペプチド2017

    • Inventor(s)
      東田千尋、郭太乙、宮崎博之
    • Industrial Property Rights Holder
      株式会社日本生物製剤、国立大学法人富山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ペリオスチン及びPKM2の分泌促進剤2017

    • Inventor(s)
      東田千尋、小谷篤
    • Industrial Property Rights Holder
      富山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-201435
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤2017

    • Inventor(s)
      東田千尋、松谷裕二、杉本健士、
    • Industrial Property Rights Holder
      レジリオ株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-119963
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経回路網の再構築・賦活剤2017

    • Inventor(s)
      東田千尋、小松かつ子
    • Industrial Property Rights Holder
      レジリオ株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-119960
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 記憶改善用ペプチド2017

    • Inventor(s)
      東田千尋、郭太乙、宮崎博之
    • Industrial Property Rights Holder
      株式会社日本生物製剤、富山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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