Simultaneous analysis of Aβ oligomers, Aβ fibrils and phosphrylated tau protein using fluroine-MRI
| Project/Area Number |
17H03560
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Tooyama Ikuo 滋賀医科大学, 医学部, 理事 (20207533)
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| Co-Investigator(Kenkyū-buntansha) |
赤津 裕康 名古屋市立大学, 医薬学総合研究院(医学), 教授 (00399734)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 脳神経疾患 / アルツハイマー病 / 核磁気共鳴画像 / ベータアミロイド / アミロイドオリゴマー / タウタンパク / 診断 / 治療 / 脳神経 / タウ / 神経科学 / 認知症 / 神経化学 / タウプロテイン |
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| Outline of Final Research Achievements |
Molecular imaging is a useful method to detect brain regions in living patients with dementia. Although amyloid and tau imaging using positron emission tomography (PET) are clinically available, no clinical studies using magnetic resonance imaging (MRI) have been conducted. Recently, molecular imaging for dementia using Fluorine-19 (19F) MRI has received an attention. Because 19F displays an intense nuclear magnetic resonance (NMR) signal and is almost non-existent in the body, a target can be detected with a high signal-to-noise ratio using fluorinated contrast agents using fluorine-MRI. We have developed several probes for molecular imaging of dementia using fluorine-MRI. These include Shiga-X22 and Shiga-Y5 for amyloid imaging and Shiga-X35 for tau imaging. In addition, we describe double-MR images of Shiga-Y5 and Shiga-X22 in the brains of APP/PS1 mice using 19F chemical shift imaging in order to detect amyloid oligomers.
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病モデルマウスを用いて、フッ素MR画像法においては、世界2例目となるアミロイドイメージグ、世界初となるタウイメージング、フッ素2重画像法による世界初のAβオリゴマーの画像化に成功した。フッ素MR画像法は、PETに比べ放射性同位体を使わない、くり返し測定が可能、サイクロトロンのような高価な施設がいらない、など利点が多い。多重フッ素MR画像法のように複数の病変を同時に画像化することも可能である。こうした点から、フッ素MR画像法は次世代の分子イメージング技術として期待されている。フッ素MR画像技術など革新的な基礎技術をわが国で開発しておくことは、国際競争に打ち勝つためにも重要である。
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Report
(5 results)
Research Products
(41 results)
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[Journal Article] Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils2021
Author(s)
Yanagisawa D, Kato T, Taguchi H, Shirai N, Hirao K, Sogabe T, Tomiyama T, Gamo K, Hirahara Y, Kitada M, Tooyama I
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Journal Title
Biomaterials
Volume: 270
Pages: 120686-120686
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020
Author(s)
Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
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Journal Title
Journal of Alzheimer's Disease
Volume: -
Issue: 1
Pages: 45-60
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.2019
Author(s)
Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Makpol S, Wan Ngah WZ, Damanhuri HA, Tooyama I
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Journal Title
Alzheimers Dis.
Volume: 72
Issue: 1
Pages: 229-246
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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