| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
Splicing specific knockout mouse of neurexin3 exon25b was established, which has been suggested to bind to C1ql family molecules. With a specific antibody both, co-localized synapses were identified. But the interaction of these two molecules was not responsible for either synaptic localization. In splicing specific knockout mouse of neurexin3 exon25b, common abnormality in presynaptic function, defects in synaptic vesicle pooling was observed as C1ql knockout mouse. This indicate that both collaborated and worked on the presynaptic region.In addition, it was discovered that N-terminal region in kainate receptor subunits have ability of presynaptic differentiation. This function was specific in glutamatergic synapse, and the combination with C1ql was not indispensable and there was not the participation of neurexin.
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