| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
Chronic obstructive pulmonary disease (COPD) is mainly characterized by pulmonary obstruction caused by chronic mucus hypersecretion and inflammation, that ultimately lead to death from respiratory failure. We have established airway-specific overexpression of the epithelial Na+ channel β subunit in mice with C57BL/6J background (C57BL/6J-βENaC-Tg mice) as a pathophysiologically highly useful COPD mouse model. The study aimed to identify and prove pulmo-modulatory factors that affect COPD phenotype by experimental analysis of C57BL/6J-βENaC-Tg mice and a cross-sectional and a retrospective longitudinal studies with Japanese participants in a health screening program. We determined glucagon-like peptide-1 and palmitic acid as exacerbating factors, while uric acid as a protective factor specifically in female, in the pathogenesis of COPD. Moreover, we identified Melinjo seed extracts as well as macloride Azithromycin as useful agents that suppress COPD phenotypes.
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