| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We demonstrated for the first time that niche-induced Jagged1-Notch signaling activates PKC, subsequently phosphorylates MARCKS, and finally leads to the proliferation, survival and acquired resistance to bortezomib in multiple myeloma cells. as a molecular mechanism of Notch signaling activation through cancer niche. In addition, in order to analyze the interactions that occur specifically between multiple myeloma cells and niches, we performed an interactome analysis using xenograft models and identified nine interactions that may be involved in bortezomib resistance. The effect of SEMA3A-NRP1 on bortezomib susceptibility among the candidates is currently being analyzed in multiple myeloma cells and bone marrow stroma cells.
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