| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
We conducted comprehensive search of the molecular basis of RB1 function in the context of various malignant progresses, and found that SREBP transcription factors and PGAM1 and 2 are important targets of RB1. Based on these findings, we proposed a concept that RB1 regulates undifferentiated behavior of cells by controlling the metabolism in addition to regulating the cell cycle and coordinating with tissue-specific transcription factors. By analyzing in detail the mechanism by which RB1 regulates metabolism and its physiological significance, we are clarifying the true nature of cancer metabolism as a target for cancer treatment. We also obtained POCs for some of the target genes of RB1 as therapeutic targets.
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