| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
|---|
| Outline of Final Research Achievements |
We identified that TUG1 (taurine upregulated gene 1) is an indispensable long noncoding RNA (lncRNA) to regulate intrinsic DNA replication stress (RS)/ DNA repair in cancer cells. When replication was disrupted, the ATR signaling pathway was activated and immediately induced transcription of TUG1. Mechanistically, TUG1 promoted recruitment of replication protein A (RPA) to the replication forks. Our data reveal a novel spatiotemporal role of TUG1 as an indispensable molecule to relieve RS in cancer cells and provide a strong rationale for targeting TUG1 as a specific and potent therapeutic approach for cancer treatment.
|
