Molecular epidemiologic studies of colorectal cancer for understanding the etiology and development of preventive measures based on Japanese population including Japanese descent

• Project/Area Number: 17H03588
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Iwasaki Motoki 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 部長 (60392338)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: 分子疫学 / 大腸がん / 日系移民 / 交互作用

Outline of Final Research Achievements

We examined a gene-environment interaction to clarify whether genetic factors may modify an association between environmental factors and risk of colorectal cancer and performed a mediation analysis to decompose total effect of obesity on colorectal cancer risk into direct effect and indirect effects by inflammatory and metabolic biomarkers based on epidemiological studies for colorectal neoplasia among Japanese population including Japanese descent. Evidence from these studies might contribute to further understand colorectal carcinogenesis and develop preventive measures.

Academic Significance and Societal Importance of the Research Achievements

遺伝環境交互作用は、同じ環境要因を曝露しても遺伝的素因の違いにより発がんリスクが異なるかどうかを明らかにするもで、個別化予防につながる重要なエビデンスとなる。効果の分解により、血漿バイオマーカーを介した発がん経路が明らかとなれば、メカニズムの解明に貢献するだけでなく、予防介入試験のターゲットやその効果判定の中間指標にも繋がり得るエビデンスとなる。

Research Products

• [Int'l Joint Research] University of Hawaii(米国)
• [Int'l Joint Research] Nikkei Disease Prevention Center(ブラジル)
• [Int'l Joint Research] Nikkei Disease Prevention Center(ブラジル)
• [Int'l Joint Research] University of Hawaii(米国)
• [Int'l Joint Research] University of Hawaii(米国)
• [Int'l Joint Research] Nikkei Disease Prevention Center(ブラジル)
• [Journal Article] Dietary Intake of Branched-Chain Amino Acids and Risk of Colorectal Cancer. (2020)
  • Author(s): Katagiri R, Song M, Zhang X, Lee DH, Tabung FK, Fuchs CS, Meyerhardt JA, Nishihara R, Chan AT, Joshi AD, Iwasaki M, Ogino S, Willett WC, Giovannucci E, Wu K.
  • Journal Title: Cancer Prev Res Volume: 13 Issue: 1 Pages: 65-72
  • DOI: 10.1158/1940-6207.capr-19-0297
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians. (2019)
  • Author(s): Budhathoki S, Iwasaki M, Yamaji T, Hamada GS, Miyajima NT, Zampieri JC, Sharma S, Pakseresht M, Kolahdooz F, Ishihara J, Takachi R, Charvat H, Le Marchand L, Tsugane S.
  • Journal Title: Eur J Cancer Prev. Volume: 印刷中 Issue: 1 Pages: 7-14
  • DOI: 10.1097/cej.0000000000000506
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between plasma concentrations of branched-chain amino acids and adipokines in Japanese adults without diabetes (2018)
  • Author(s): Katagiri Ryoko、Goto Atsushi、Budhathoki Sanjeev、Yamaji Taiki、Yamamoto Hiroshi、Kato Yumiko、Iwasaki Motoki、Tsugane Shoichiro
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1043-1043
  • DOI: 10.1038/s41598-018-19388-w
  • Peer Reviewed / Open Access
• [Journal Article] Association of plasma concentrations of branched-chain amino acids with risk of colorectal adenoma in a large Japanese population (2017)
  • Author(s): Budhathoki S.、Iwasaki M.、Yamaji T.、Yamamoto H.、Kato Y.、Tsugane S.
  • Journal Title: Annals of Oncology Volume: 28 Issue: 4 Pages: 818-823
  • DOI: 10.1093/annonc/mdw680
  • Peer Reviewed
• [Presentation] 住民ベースコホートデータを用いた多因子疾患としてのがんのリスク予測 (2019)
  • Author(s): 岩崎 基
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 血液中分岐鎖アミノ酸濃度と膵臓がん罹患の関連について：コホート 内症例対照研究 (2019)
  • Author(s): 片桐諒子、後藤温、西海信、小林隆、日高章寿、山地太樹、澤田典絵、島津太一、井上真奈美、岩崎基、吉田優、津金昌一郎
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 糖尿病のない日本人集団における血液中分岐鎖アミノ酸濃度とアディポカイン濃度の関連 (2019)
  • Author(s): 片桐諒子、後藤温、Sanjeev Budhathoki、山地太樹、山本浩史、加藤由美子、岩崎基、津金昌一郎
  • Organizer: 第89回日本衛生学会学術総会
• [Presentation] Dietary carcinogens and cancer risk: findings from Japanese Studies (2018)
  • Author(s): Motoki Iwasaki
  • Organizer: 2018 World Cancer Congress
  • Int'l Joint Research
• [Presentation] がん罹患リスクに対する環境発がん要因と遺伝素因の交互作用の検討 (2017)
  • Author(s): 岩崎 基
  • Organizer: 第76回日本癌学会学術総会
• [Remarks] 国立がん研究センターのがん検診受診者を対象とした研究
  • URL: http://epi.ncc.go.jp/mstudy/491/7888.html