Molecular epidemiologic studies of colorectal cancer for understanding the etiology and development of preventive measures based on Japanese population including Japanese descent
| Project/Area Number |
17H03588
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Iwasaki Motoki 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 部長 (60392338)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | 分子疫学 / 大腸がん / 日系移民 / 交互作用 |
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| Outline of Final Research Achievements |
We examined a gene-environment interaction to clarify whether genetic factors may modify an association between environmental factors and risk of colorectal cancer and performed a mediation analysis to decompose total effect of obesity on colorectal cancer risk into direct effect and indirect effects by inflammatory and metabolic biomarkers based on epidemiological studies for colorectal neoplasia among Japanese population including Japanese descent. Evidence from these studies might contribute to further understand colorectal carcinogenesis and develop preventive measures.
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| Academic Significance and Societal Importance of the Research Achievements |
遺伝環境交互作用は、同じ環境要因を曝露しても遺伝的素因の違いにより発がんリスクが異なるかどうかを明らかにするもで、個別化予防につながる重要なエビデンスとなる。効果の分解により、血漿バイオマーカーを介した発がん経路が明らかとなれば、メカニズムの解明に貢献するだけでなく、予防介入試験のターゲットやその効果判定の中間指標にも繋がり得るエビデンスとなる。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Dietary Intake of Branched-Chain Amino Acids and Risk of Colorectal Cancer.2020
Author(s)
Katagiri R, Song M, Zhang X, Lee DH, Tabung FK, Fuchs CS, Meyerhardt JA, Nishihara R, Chan AT, Joshi AD, Iwasaki M, Ogino S, Willett WC, Giovannucci E, Wu K.
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Journal Title
Cancer Prev Res
Volume: 13
Issue: 1
Pages: 65-72
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians.2019
Author(s)
Budhathoki S, Iwasaki M, Yamaji T, Hamada GS, Miyajima NT, Zampieri JC, Sharma S, Pakseresht M, Kolahdooz F, Ishihara J, Takachi R, Charvat H, Le Marchand L, Tsugane S.
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Journal Title
Eur J Cancer Prev.
Volume: 印刷中
Issue: 1
Pages: 7-14
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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