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Skeletal muscle differentiation regulated by chromatin composition

Research Project

Project/Area Number 17H03608
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Genome biology
Research InstitutionKyushu University

Principal Investigator

Ohkawa Yasuyuki  九州大学, 生体防御医学研究所, 教授 (80448430)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywordsクロマチン / ヒストンバリアント / 骨格筋分化 / 転写調節 / エピゲノム解析 / 発現制御 / 遺伝子 / 発生・分化 / エピゲノム / クロマチン構造 / 細胞分化
Outline of Final Research Achievements

In cell differentiation, a group of differentiation-related genes are selectively expressed by various epigenome regulations including transcription factors and histone modifications. In recent years, it has been cleared that histone variants form a chromatin structure at a specific composition ratio and are widely involved in the selective gene expression on the genome to the regulation of transcriptional amount. However, there are still many unclear points about the formation mechanism and function. Therefore, in the present study, novel identified skeletal muscle-specific histone variants from the selection of differentiation genes in the process of reaching various precursor cells and mature muscle tissues in the process from skeletal muscle stem cells to mature muscle tissues. We have elucidated the chromatin composition on the genome and its function when controlling the transcription level, some of which have been published and others have been submitted.

Academic Significance and Societal Importance of the Research Achievements

本研究では、骨格筋幹細胞から筋肉を形成する遺伝子発現プログラムの解明を進めた。細胞内の遺伝子発現は、クロマチン構造の変換により制御されている。その構造を担っているのが、ヒストンである。本研究ではヒストンの亜種の解析、特に骨格筋幹細胞に発現するものに焦点を絞って解析を行い、骨格筋分化を促進、あるいは阻害する機能をもつ新規ヒストンを同定した。今後これらヒストンを起点とした筋再生機構の解明や応用が期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (89 results)

All 2020 2019 2018 2017 Other

All Journal Article (46 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 46 results,  Open Access: 43 results,  Acknowledgement Compliant: 3 results) Presentation (39 results) (of which Int'l Joint Research: 9 results,  Invited: 14 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] The role of galanin in the differentiation of mucosal mast cells in mice.2020

    • Author(s)
      Yamaguchi T., Ikeda Y., Tashiro K., Ohkawa Y., Kawabata K.
    • Journal Title

      Eur. J. Immunol.

      Volume: 50 Issue: 1 Pages: 110-118

    • DOI

      10.1002/eji.201848061

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells.2019

    • Author(s)
      Oka M, Mura S, Otani M, Miyamoto Y, Nogami J, Maehara K, Harada A, Tachibana T, Yoneda Y, Ohkawa Y
    • Journal Title

      Elife

      Volume: 8

    • DOI

      10.7554/elife.46667

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo2019

    • Author(s)
      Akieda Yuki、Ogamino Shohei、Furuie Hironobu、Ishitani Shizuka、Akiyoshi Ryutaro、Nogami Jumpei、Masuda Takamasa、Shimizu Nobuyuki、Ohkawa Yasuyuki、Ishitani Tohru
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 4710-4710

    • DOI

      10.1038/s41467-019-12609-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.2019

    • Author(s)
      Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada SI.
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.48284

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme.2019

    • Author(s)
      Witwicka H, Nogami J, Syed SA, Maehara K, Padilla-Benavides T, Ohkawa Y, Imbalzano AN
    • Journal Title

      Mol Cell Biol.

      Volume: 39 Issue: 19

    • DOI

      10.1128/mcb.00063-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis.2019

    • Author(s)
      †Abdalla MOA, †Yamamoto T, Maehara K, Ohkawa Y, Miura H, Hiratani I, Nakayama H, Nakao M, *Saitoh N
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 3778-3778

    • DOI

      10.1038/s41467-019-11378-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biochemical analysis of nucleosome targeting by Tn5 transposase2019

    • Author(s)
      Sato S, Arimura Y, Kujirai T, Harada A, Maehara K, Nogami J, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Open Biol.

      Volume: 9 Issue: 8 Pages: 190116-190116

    • DOI

      10.1098/rsob.190116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes.2019

    • Author(s)
      Konno D, Kishida C, Maehara K, Ohkawa Y, Kiyonari H, Okada S, Matsuzaki F
    • Journal Title

      Development

      Volume: 146 Issue: 15 Pages: 174243-174243

    • DOI

      10.1242/dev.174243

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants.2019

    • Author(s)
      Araki M, Kurihara M, Kinoshita S, Awane R, Sato T, Ohkawa Y, Inoue YH
    • Journal Title

      Dis Model Mech.

      Volume: 12 Issue: 6

    • DOI

      10.1242/dmm.037721

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.2019

    • Author(s)
      Sorida M, Hirauchi T, Ishizaki H, Kaito W, Shimada A, Mori C, Chikashige Y, Hiraoka Y, Suzuki Y, Ohkawa Y, Kato H, Takahata S, Murakami Y
    • Journal Title

      PLoS Genet.

      Volume: 15

    • NAID

      120007002166

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CLEC3A, MMP7, and LCN2 as Novel Markers for Predicting Recurrence in Resected G1 and G2 Pancreatic Neuroendocrine Tumors2019

    • Author(s)
      Miki M, Oono T, Fujimori N, Takaoka T, Kawabe K, Miyasaka Y, Ohtsuka T, Saito D, Nakamura M, Ohkawa Y, Oda N, Suyama M, Ito T, Ogawa Y.
    • Journal Title

      Cancer Medicine

      Volume: in press Issue: 8 Pages: 3748-3760

    • DOI

      10.1002/cam4.2232

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macrophage centripetal migration drives spontaneous healing process after spinal cord injury2019

    • Author(s)
      Kobayakawa K、Ohkawa Y、 Yoshizaki S、T、Saito T、Kijima Ken、Yokota K、Hara M、Kubota K、Matsumoto Y、Harimaya K、Ozato K、Masuda T、Tsuda M、Tamura T、Inoue K、Edgerton V. R、Iwamoto Y、Nakashima Y、Okada S
    • Journal Title

      Science Advances

      Volume: 5 Issue: 5

    • DOI

      10.1126/sciadv.aav5086

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection2019

    • Author(s)
      Kobayakawa Kazu、DePetro Kyleigh Alexis、Zhong Hui、Pham Bau、Hara Masamitsu、Harada Akihito、Nogami Jumpei、Ohkawa Yasuyuki、Edgerton V. Reggie
    • Journal Title

      Neurorehabilitation and Neural Repair

      Volume: 33 Issue: 3 Pages: 225-231

    • DOI

      10.1177/1545968319829456

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation.2019

    • Author(s)
      Kozuka T, Omori Y, Watanabe S, Tarusawa E, Yamamoto H, Chaya T, Furuhashi M, Morita M, Sato T, Hirose S, Ohkawa Y, Yoshimura Y, Hikida T, Furukawa T.
    • Journal Title

      Sci Rep.

      Volume: Mar 5;9(1) Issue: 1 Pages: 3445-3445

    • DOI

      10.1038/s41598-019-38910-2

    • NAID

      120006579467

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites2019

    • Author(s)
      Noguchi Yu-taro、Nakamura Miki、Hino Nobumasa、Nogami Jumpei、Tsuji Sayaka、Sato Takahiko、Zhang Lidan、Tsujikawa Kazutake、Tanaka Toru、Izawa Kohei、Okada Yoshiaki、Doi Takefumi、Kokubo Hiroki、Harada Akihito、Uezumi Akiyoshi、Gessler Manfred、Ohkawa Yasuyuki、Fukada So-ichiro
    • Journal Title

      Development

      Volume: 146 Issue: 4 Pages: 163618-163618

    • DOI

      10.1242/dev.163618

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathological changes of distal motor neurons after complete spinal cord injury2019

    • Author(s)
      Yokota Kazuya、Kubota Kensuke、Kobayakawa Kazu、Saito Takeyuki、Hara Masamitsu、Kijima Ken、Maeda Takeshi、Katoh Hiroyuki、Ohkawa Yasuyuki、Nakashima Yasuharu、Okada Seiji
    • Journal Title

      Molecular Brain

      Volume: 12 Issue: 1

    • DOI

      10.1186/s13041-018-0422-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing2019

    • Author(s)
      Matsuda Akira、Asada Yosuke、Suita Naomasa、Iwamoto Satoshi、Hirakata Toshiaki、Yokoi Norihiko、Ohkawa Yasuyuki、Okada Yukinori、Yokomizo Takehiko、Ebihara Nobuyuki
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 143 Issue: 4 Pages: 1610-1614

    • DOI

      10.1016/j.jaci.2018.11.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones2019

    • Author(s)
      Katoh-Fukui Yuko、Baba Takashi、Sato Tetsuya、Otake Hiroyuki、Nagakui-Noguchi Yuko、Shindo Miyuki、Suyama Mikita、Ohkawa Yasuyuki、Tsumura Hideki、Morohashi Ken-ichirou、Fukami Maki
    • Journal Title

      Bone

      Volume: 120 Pages: 219-231

    • DOI

      10.1016/j.bone.2018.10.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A chromatin integration labelling method enables epigenomic profiling with lower input2018

    • Author(s)
      Harada Akihito、Maehara Kazumitsu、Handa Tetsuya、Arimura Yasuhiro、Nogami Jumpei、Hayashi-Takanaka Yoko、Shirahige Katsuhiko、Kurumizaka Hitoshi、Kimura Hiroshi、Ohkawa Yasuyuki
    • Journal Title

      Nature Cell Biology

      Volume: 21 Issue: 2 Pages: 287-296

    • DOI

      10.1038/s41556-018-0248-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells2018

    • Author(s)
      Shima Yuichi、Miyabayashi Kanako、Sato Tetsuya、Suyama Mikita、Ohkawa Yasuyuki、Doi Masao、Okamura Hitoshi、Suzuki Kentaro
    • Journal Title

      Development

      Volume: 145 Issue: 23 Pages: 169136-169136

    • DOI

      10.1242/dev.169136

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors2018

    • Author(s)
      Takashima Yasuo、Horisawa Kenichi、Udono Miyako、Ohkawa Yasuyuki、Suzuki Atsushi
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 11 Pages: 3543-3553

    • DOI

      10.1111/cas.13798

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome2018

    • Author(s)
      Arimura Yasuhiro、Ikura Masae、Fujita Risa、Noda Mamiko、Kobayashi Wataru、Horikoshi Naoki、Sun Jiying、Shi Lin、Kusakabe Masayuki、Harata Masahiko、Ohkawa Yasuyuki、Tashiro Satoshi、Kimura Hiroshi、Ikura Tsuyoshi、Kurumizaka Hitoshi
    • Journal Title

      Nucleic Acids Research

      Volume: - Pages: 10007-10018

    • DOI

      10.1093/nar/gky661

    • NAID

      120006545208

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MNase, as a probe to study the sequence-dependent site exposures in the +1 nucleosomes of yeast2018

    • Author(s)
      Luo Di、Kato Daiki、Nogami Jumpei、Ohkawa Yasuyuki、Kurumizaka Hitoshi、Kono Hidetoshi
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: 14 Pages: 7124-7137

    • DOI

      10.1093/nar/gky502

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells2018

    • Author(s)
      Sugimoto Nozomi、Maehara Kazumitsu、Yoshida Kazumasa、Ohkawa Yasuyuki、Fujita Masatoshi
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: 13 Pages: 6683-6696

    • DOI

      10.1093/nar/gky476

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of miR-305, a microRNA that promotes aging, and its target mRNAs in Drosophila2018

    • Author(s)
      Ueda Makiko、Sato Tetsuya、Ohkawa Yasuyuki、Inoue Yoshihiro H.
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 2 Pages: 80-93

    • DOI

      10.1111/gtc.12555

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration2018

    • Author(s)
      Harada Akihito、Maehara Kazumitsu、Ono Yusuke、Taguchi Hiroyuki、Yoshioka Kiyoshi、Kitajima Yasuo、Xie Yan、Sato Yuko、Iwasaki Takeshi、Nogami Jumpei、Okada Seiji、Komatsu Tetsuro、Semba Yuichiro、Takemoto Tatsuya、Kimura Hiroshi、Kurumizaka Hitoshi、Ohkawa Yasuyuki
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1400-1400

    • DOI

      10.1038/s41467-018-03845-1

    • NAID

      120006949474

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids2018

    • Author(s)
      Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro Ishihara, Ju-Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, Lixiang Wang, Ryuichiro Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man Ho Choi, Yasuyuki Ohkawa & Ken-ichirou Morohashi
    • Journal Title

      Communications Biology

      Volume: 1 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s42003-018-0020-z

    • NAID

      120006799378

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sensitive detection of fluorescence in western blotting by merging images2018

    • Author(s)
      Kondo Yukari、Higa Shinichiro、Iwasaki Takeshi、Matsumoto Tomoya、Maehara Kazumitsu、Harada Akihito、Baba Yoshihiro、Fujita Masatoshi、Ohkawa Yasuyuki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: 0191532-0191532

    • DOI

      10.1371/journal.pone.0191532

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis2018

    • Author(s)
      Kita Yasuyuki、Katayama Yuta、Shiraishi Taichi、Oka Takeru、Sato Tetsuya、Suyama Mikita、Ohkawa Yasuyuki、Miyata Keishi、Oike Yuichi、Shirane Michiko、*Nishiyama Masaaki、*Nakayama Keiichi I.
    • Journal Title

      Cell Reports

      Volume: 23 Issue: 7 Pages: 1988-2000

    • DOI

      10.1016/j.celrep.2018.04.050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence2018

    • Author(s)
      Takizawa Yoshimasa、Tanaka Hiroki、Machida Shinichi、Koyama Masako、Maehara Kazumitsu、Ohkawa Yasuyuki、Wade Paul A.、Wolf Matthias、Kurumizaka Hitoshi
    • Journal Title

      Open Biology

      Volume: 8 Issue: 3 Pages: 170255-170255

    • DOI

      10.1098/rsob.170255

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Direct Reprogramming of Spiral Ganglion Non-neuronal Cells into Neurons: Toward Ameliorating Sensorineural Hearing Loss by Gene Therapy2018

    • Author(s)
      Noda T, Meas SJ, Nogami J, Amemiya Y, Uchi R, Ohkawa Y, Nishimura K, Dabdoub A
    • Journal Title

      Front Cell Dev Biol

      Volume: 6:16 Pages: 1-14

    • DOI

      10.3389/fcell.2018.00016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Temporal regulation of chromatin during myoblast differentiation2017

    • Author(s)
      Harada Akihito、Ohkawa Yasuyuki、Imbalzano Anthony N.
    • Journal Title

      Seminars in Cell & Developmental Biology

      Volume: 72 Pages: 77-86

    • DOI

      10.1016/j.semcdb.2017.10.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of histone H3.5 in human spermatogenesis and spermatogenic disorders2017

    • Author(s)
      Shiraishi K.、Shindo A.、Harada A.、Kurumizaka H.、Kimura H.、Ohkawa Y.、Matsuyama H.
    • Journal Title

      Andrology

      Volume: 6 Issue: 1 Pages: 158-165

    • DOI

      10.1111/andr.12438

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi2017

    • Author(s)
      Kajitani Takuya、Kato Hiroaki、Chikashige Yuji、Tsutsumi Chihiro、Hiraoka Yasushi、Kimura Hiroshi、Ohkawa Yasuyuki、Obuse Chikashi、Hermand Damien、Murakami Yota
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 114 Issue: 52

    • DOI

      10.1073/pnas.1714579115

    • NAID

      120006539374

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone methyltransferase G9a is a key regulator of the starvation-induced behaviors in Drosophila melanogaster.2017

    • Author(s)
      Shimaji, K., Tanaka, R., Maeda, T., Ozaki, M., Yoshida, H., Ohkawa, Y., Sato, T., Suyama, M. and Yamaguchi, M.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14763-14763

    • DOI

      10.1038/s41598-017-15344-2

    • NAID

      120006368029

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms.2017

    • Author(s)
      Adachi Y, Umeda M, Kawazoe A, Sato T, Ohkawa Y, Kitajima S, Izawa S, Sagami I, Taketani S.
    • Journal Title

      Arch Biochem Biophys.

      Volume: 631 Pages: 19-29

    • DOI

      10.1016/j.abb.2017.08.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1.2017

    • Author(s)
      Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, Ohkawa Y, Yokomizo T
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: 0185133-0185133

    • DOI

      10.1371/journal.pone.0185133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation2017

    • Author(s)
      Kudou Kensuke、Komatsu Tetsuro、Nogami Jumpei、Maehara Kazumitsu、Harada Akihito、Saeki Hiroshi、Oki Eiji、Maehara Yoshihiko、Ohkawa Yasuyuki
    • Journal Title

      Open Biology

      Volume: 7 Issue: 9 Pages: 170119-170119

    • DOI

      10.1098/rsob.170119

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability2017

    • Author(s)
      Fukuda Kei、Inoguchi Yukihiro、Ichiyanagi Kenji、Ichiyanagi Tomoko、Go Yasuhiro、Nagano Masashi、Yanagawa Yojiro、Takaesu Noboru、Ohkawa Yasuyuki、Imai Hiroo、Sasaki Hiroyuki
    • Journal Title

      Human Molecular Genetics

      Volume: 26 Issue: 18 Pages: 3508-3519

    • DOI

      10.1093/hmg/ddx236

    • NAID

      120006367980

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Persistent detection of alternatively spliced BCR-ABL variant results in a failure to achieve deep molecular response2017

    • Author(s)
      Yuda Junichiro、Miyamoto Toshihiro、Odawara Jun、Ohkawa Yasuyuki、Semba Yuichiro、Hayashi Masayasu、Miyamura Koichi、Tanimoto Mitsune、Yamamoto Kazuhito、Taniwaki Masafumi、Akashi Koichi
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 11 Pages: 2204-2212

    • DOI

      10.1111/cas.13353

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin?N-cadherin pathway after spinal cord injury2017

    • Author(s)
      Hara Masamitsu、Kobayakawa Kazu、Ohkawa Yasuyuki、Kumamaru Hiromi、Yokota Kazuya、Saito Takeyuki、Kijima Ken、Yoshizaki Shingo、Harimaya Katsumi、Nakashima Yasuharu、Okada Seiji
    • Journal Title

      Nature Medicine

      Volume: 23 Issue: 7 Pages: 818-828

    • DOI

      10.1038/nm.4354

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells2017

    • Author(s)
      Semba Yuichiro、Harada Akihito、Maehara Kazumitsu、Oki Shinya、Meno Chikara、Ueda Jun、Yamagata Kazuo、Suzuki Atsushi、Onimaru Mitsuho、Nogami Jumpei、Okada Seiji、Akashi Koichi、Ohkawa Yasuyuki
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Issue: 15 Pages: 8758-8772

    • DOI

      10.1093/nar/gkx475

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes2017

    • Author(s)
      Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Ohkawa Y,他39名
    • Journal Title

      Ann Rheum Dis.

      Volume: 76 Issue: 5 Pages: 869

    • DOI

      10.1136/annrheumdis-2016-209632

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.82017

    • Author(s)
      Taguchi H, Xie Y, Horikoshi N, Maehara K, Harada A, Nogami J, Sato K, Arimura Y, Osakabe A, Kujirai T, Iwasaki T, Semba Y, Tachibana T, Kimura H, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Biochemistry

      Volume: 56 Issue: 16 Pages: 2184-2196

    • DOI

      10.1021/acs.biochem.6b01098

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thymine DNA glycosylase modulates the DNA damage response and gene expression by base excision repair-dependent and -independent mechanisms2017

    • Author(s)
      Tomohumi Nakamura, Kouichi Murakami, Haruto Tada, Yoshihiko Uehara, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Hisato Saitoh, Hideo Nishitani, Tetsuya Ono, Ryotaro Nishi, Masayuki Yokoi, Wataru Sakai, and Kaoru Sugasawa
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 4 Pages: 392-405

    • DOI

      10.1111/gtc.12481

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal structure of the overlapping dinucleosome composed of hexasome and octasome2017

    • Author(s)
      Daiki Kato, Akihisa Osakabe, Yasuhiro Arimura, Yuka Mizukami, Naoki Horikoshi, Kazumi Saikusa, Satoko Akashi, Yoshifumi Nishimura, Sam-Yong Park, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Atsushi Matsumoto, Hidetoshi Kono, Rintaro Inoue, Masaaki Sugiyama, Hitoshi Kurumizaka
    • Journal Title

      Science

      Volume: 356 Issue: 6334 Pages: 205-208

    • DOI

      10.1126/science.aak9867

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 遺伝子の発現されやすさはどのように決まるのか?~クロマチンが規定する遺伝子発現制御能力~2019

    • Author(s)
      大川恭行
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of chromatin integration labeling technology for single cell multiomics2019

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Spatial epigenomics approached by chromatin integration labeling technology2019

    • Author(s)
      大川恭行
    • Organizer
      Trans-Omics for Advanced Medical Sciences
    • Related Report
      2019 Annual Research Report
  • [Presentation] クロマチン挿入法による単一細胞エピゲノム解析2019

    • Author(s)
      大川恭行
    • Organizer
      日本人類遺伝学会第64回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chromatin integration labelling Technology for expanding multi-omics2019

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      EMBO Symposia: Multi-Omics
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chromatin integration labelling technology for expanding multi-omics2019

    • Author(s)
      大川恭行
    • Organizer
      第13回国際ゲノム会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞ポテンシャル測定システムの開発2019

    • Author(s)
      大川恭行
    • Organizer
      CREST領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 1細胞トランスクリプトミクス による骨格筋特異的クロマチン構造の解明 発表2019

    • Author(s)
      大川恭行
    • Organizer
      ゲノム編集班会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] Transcriptional Plasticity regulated by novel Histone H3 Varigants2019

    • Author(s)
      大川恭行
    • Organizer
      理研連携プロジェクト「エピゲノム操作」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Chromatin Integration Labeling- an Epigenomic Profiling for Single Cell Analysis2019

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      Cell Symposium: Single Cells: Technology to Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨格筋再生におけるヒストン転換2019

    • Author(s)
      大川恭行
    • Organizer
      第7回骨格筋生物学研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 単一細胞レベルのエピゲノム解析技術2019

    • Author(s)
      大川恭行
    • Organizer
      九大発産・学・官交流促進シーズ発表会2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] Low-input Epigenomic Profiling Technology toward Identifying Myogenic Chomatin Structure.2018

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      Muscle Development, Regeneration and Disease 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遺伝子発現能から迫る骨格筋再生機構の解明~トランスクリプトミクスによるアプローチ~2018

    • Author(s)
      大川恭行
    • Organizer
      NCNP神経研究所セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 1細胞エピゲノム解析技術の開発2018

    • Author(s)
      大川恭行
    • Organizer
      第12回日本エピジェネティクス研究会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ゲノムワイドな遺伝子発現制御機構を基盤とした神経組織特異的クロマチン構造の解明2018

    • Author(s)
      大川恭行
    • Organizer
      【ゲノム編集】キックオフミーティング
    • Related Report
      2018 Annual Research Report
  • [Presentation] ChiLT-an epigenomic Profiling for Single Cell Analysis2018

    • Author(s)
      大川恭行
    • Organizer
      第2回代謝統合オミクス領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] クロマチン組成変化から考える細胞分化能制御~トランスクリプトミクスの新たな展開~2018

    • Author(s)
      大川恭行
    • Organizer
      東京大学理学部研究セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] ChiLT-an Epigenomic Profiling for Single Cell Analysis2018

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      Gordon Research Conference「Chromatin Encounters Shaping Genome Architecture and Function」
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histone H3.3 sub-variants are required for regulating skeletal muscle differentiation.2018

    • Author(s)
      Yasuyuki Ohkawa
    • Organizer
      2018 Federation of American Societies for Experimental Biology (FASEB)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histone composition in chromatin regulates skeletal muscle regeneration2018

    • Author(s)
      大川恭行
    • Organizer
      The 6th Society of Skeletal Muscle Cells
    • Related Report
      2018 Annual Research Report
  • [Presentation] ChILT- an Epigenomic Profiling for Single Cell Analysis2018

    • Author(s)
      大川恭行
    • Organizer
      CDBシンポジウム2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3の選択による細胞分化制御機構 ~トランスクリプトミクスによるアプローチ~2018

    • Author(s)
      大川恭行
    • Organizer
      よこはまNMR研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3の選択による細胞分化制御機構~トランスクリプトミクスによるアプローチ~2018

    • Author(s)
      大川恭行
    • Organizer
      群馬大学生調研セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 骨格筋再生を制御するゲノムワイドな遺伝子制御機構~ヒストンの組成変化が拓く新たなエピゲノム制御~2018

    • Author(s)
      大川恭行
    • Organizer
      PROS学術シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 1細胞エピゲノム解析技術の開発2018

    • Author(s)
      大川恭行
    • Organizer
      日本がん分子標的治療学会TRワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゲノムから遺伝子が選ばれる仕組み2018

    • Author(s)
      大川恭行
    • Organizer
      クロマチン一般公開シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンバリアントによる細胞運命決定機構2017

    • Author(s)
      大川恭行
    • Organizer
      京都大学 学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3バリアントで制御される組織特異的構造 Tissue-specific Chromatin Structures regulated by Histone H3 Variants2017

    • Author(s)
      大川恭行
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ChILT - an immunoprecipitation-free epigenome profiling technology2017

    • Author(s)
      大川恭行
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tissue-specific Chromatin Structures According to Histone H3 Variants2017

    • Author(s)
      大川恭行
    • Organizer
      研究セミナー
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒストンバリアントによる組織特異的クロマチン構造の形成2017

    • Author(s)
      大川恭行
    • Organizer
      日本遺伝学会第89回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Myogenic chromatin structure is formed with the novel histone H3 variant.2017

    • Author(s)
      大川恭行
    • Organizer
      EMBO Workshop Histone Vriants
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ChILT - an Immunoprecipitation-free Epigenome Profiling Technology.2017

    • Author(s)
      大川恭行
    • Organizer
      1st Munchen-Japan Mini Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 骨格筋再生の核内プログラム~トランスクリプトミクス解析の新たな展開~2017

    • Author(s)
      大川恭行
    • Organizer
      運動器科学研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Tissue‐specific Chromatin Structures According to Histone H3 Variants2017

    • Author(s)
      大川恭行
    • Organizer
      第12回国際ゲノム会議
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Myogenic Chromatin Structure Is Formed with the Histone H3 Variant H3mm72017

    • Author(s)
      大川恭行
    • Organizer
      Gordon Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ChiLT-an Immunoprecipitation-free Epigenome Profiling Technology2017

    • Author(s)
      大川恭行
    • Organizer
      Single Cell Omics (E3)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒストンH3バリアントによる骨格筋特異的クロマチン構造制御2017

    • Author(s)
      大川恭行
    • Organizer
      第11回日本エピジェネティクス研究会年会
    • Related Report
      2017 Annual Research Report
  • [Book] 実験医学2019

    • Author(s)
      原田 哲仁,大川 恭行
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2019 Annual Research Report
  • [Remarks] Ohkawa lab

    • URL

      http://tx.bioreg.kyushu-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 対象核酸の塩基配列を1細胞レベルで並列に検出する方法2020

    • Inventor(s)
      大川 恭行、原田哲仁
    • Industrial Property Rights Holder
      国立大学法人九州大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] DNA結合タンパク質の結合領域の近傍に所望のDNA断片を挿入する方法2017

    • Inventor(s)
      大川恭行,原田哲仁,胡桃坂仁志,木村宏,半田哲也,他2名
    • Industrial Property Rights Holder
      大川恭行,原田哲仁,胡桃坂仁志,木村宏,半田哲也,他2名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas

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Published: 2017-04-28   Modified: 2021-02-19  

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