| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Using a microbial comparative genome database (MBGD), we have conducted comprehensive analysis of horizontal gene transfer among prokaryotic genomes. We considered “non-core genes,” i.e. genes that are not conserved among the genomes of the same species, as candidates of horizontally transferred genes, and constructed a structure consisting of non-core genes with conserved gene order. Moreover, we identified orthologous relationships among the entire gene repertoire of species (pan-genome) and extracted non-core genes that appear in distantly related organisms. In addition to these results, we added conventional indices of horizontal gene transfer and knowledge of known mobile genetic elements and constructed a database of comprehensive prediction of horizontally transferred genes among prokaryotes.
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