| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Type 1 diabetes (T1D) occurs through autoimmune-mediated destruction of insulin-producing beta cells in pancreas. The mechanism through which the beta-cells are targeted by self-reactive T-cells have not been fully uncovered. To elucidate the mechanism of T1D, we used non-obese diabetic (NOD) mice, which spontaneously develop T1D, and generated mutant NOD mice that carried mutations in immune molecules. We followed the incidence of T1D for each mutant strain and analyzed immunological responses, to elucidate the relation between immunological function and T1D incidence.
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