| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Overexpression of certain proteins inhibits cell proliferation. However, the mechanism of this is largely unknown. Our previous studies have shown that the depletion of essential factors due to an overload of proteins transported in the cell--transportation overload--may explain most of the growth inhibition caused by overexpression. In this study, we aimed to elucidate the mechanism of growth inhibition by transport overload through the identification of proteins that cause transport overload and restriction factors that are targets of overload. As a result, we identified several candidate limiting factors for nuclear transport in particular.
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