| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Target capture sequencing that is designed to selectively sequence exons and conserved non-coding regions was performed to search for disease-causing mutations in disease model rats. Although no significant candidate mutations have yet to be detected, we found that many ancestral polymorphisms remain in the rat strains based on the analysis of sequencing data accumulated so far. In particular, such polymorphisms were abundantly accumulated in genes involved in the immune system and olfactory receptors. These polymorphisms are likely to be found in regions where many alleles had been presented in the ancestral strains. Furthermore, the fact that there are still many heterozygotes in these regions, although they are inbred strains, can be interpreted as balancing selection is working on these regions.
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