| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Structural and functional analysis of taste receptor from medaka fish, T1r2a/T1r3, was performed. Currently, the sole structural information of taste receptors so far reported is the crystal structure of the ligand-binding domain (LBD) of medaka T1r2a/T1r3 in complex with its taste substance, an amino acid. In this study, we elucidated the various conformation of this protein and a change of the conformational population upon binding of taste substances. These results suggest that the change of conformational dynamics of the LBD of taste receptor correlates with its signal transduction.
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