| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Multicellular organisms, including humans, regulate body growth through metabolic adaptations in response to changes in the external environment, such as nutritional status. Proper regulation of the glucose concentration in circulation is required to maintain homeostasis and tissue growth. Using a model organism, the fruitfly Drosophila melanogaster, we elucidated the tissue-specific starvation response of polysaccharide glycogen and its physiological significance in glucose homeostasis. We also found that disruption of glucose homeostasis during the growth phase causes organ size variability (reduced developmental homeostasis). Thus, our work provides new insights into the adaptive strategies against the fluctuation of the nutritional environment.
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