| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Dynein is a huge microtubule-based motor protein complex that drives a wide range of biological processes in eukaryotic cells, including cell division, cell migration and intracellular centripetal trafficking. However, the mechanism by which dynein moves along microtubules, which underlies its diverse intracellular functions, is still a mystery. In this study, we discovered a novel intermediate state in the dynein force generation process and determined its structure at near-atomic resolution. This study provides a structural basis for understanding the mechanism underlying dynein-based centripetal transport system.
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