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Peroxisome biogenesis and human disorders

Research Project

Project/Area Number 17H03675
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research Institution株式会社レオロジー機能食品研究所 (2019)
Kyushu University (2017-2018)

Principal Investigator

Fujiki Yukio  株式会社レオロジー機能食品研究所, 未登録, 顧問研究員、九州大学-レオロジー機能食品研究所 共同研究代表 (70261237)

Co-Investigator(Kenkyū-buntansha) 田村 茂彦  九州大学, 基幹教育院, 教授 (90236753)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywordsペルオキシソーム / PEX遺伝子 / カタラーゼ細胞内輸送制御 / プラスマローゲン / 神経形成障害 / 脳由来神経栄養因子(BDNF) / ノックアウトマウス / 膜形成 / オルガネラ分裂
Outline of Final Research Achievements

We have investigated peroxisome biogenesis and human deficiency disorders (PBD). A number of outcomes include 1) we identified two splicing variants localized to peroxisomes of human mitochondrial Rho GTPase-1 (Miro1), both being involved in microtubule-dependent long-range movement of peroxisomes; 2) we discovered that the catalase released from peroxisomes via BAK pore eliminates H2O2, a toxic and major causative of the oxidative stress, in the cytosol for cell survival; 3) we discovered that the 17-kDa nucleoside diphosphate kinase-like protein, DYNAMO1, locally generates GTP in mitochondrial division and peroxisome-dividing machineries; 4) to uncover the pathological mechanisms underlying PBD, we established a new PBD mouse model that is defective in Pex14, termed the Pex14ΔC/ΔC mouse. The Pex14ΔC/ΔC mouse shows an impaired dendritic development of Purkinje cells in cerebellum that is caused by a dysregulation of the brain-derived neurotrophic factor (BDNF)-TrkB pathway.

Academic Significance and Societal Importance of the Research Achievements

細胞機能の発現は、新生タンパク質の細胞内小器官への選別輸送・局在化により実現される。その障害は、オルガネラ欠損症などの重篤な病態をもたらす。本研究では、ペルオキシソームの形成と欠損症の分子基盤解明に取り組んだ。代表的成果として、ペルオキシソームの細胞内移動を担うMiro1分子の発見、酸化ストレス時のカタラーゼによる細胞死防御戦略の発見、ペルオキシソームやミトコンドリアの分裂に必須なGTP供給因子Dynamo1の発見、世界で初めてのペルオキシソーム欠損症の小脳形成障害機構の解明等がある。多くの新知見は他のオルガネラの生体内恒常性維持機構とその破綻の解明研究にも大きな波及効果を有する。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (93 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (23 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 23 results,  Open Access: 23 results) Presentation (54 results) (of which Int'l Joint Research: 16 results,  Invited: 9 results) Book (9 results) Remarks (2 results)

  • [Int'l Joint Research] Columbia大学/Stanford大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Wien医科大学(オーストリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] FMI研究所(スイス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Columbia大学/Stanford大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Wien医科大学(オーストリア)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Peroxisome counteracts oxidative stresses by suppressing catalase import via phosphorylation of Pex14 in the import machinery.2020

    • Author(s)
      Okumoto, K., El Shermely, M., Natsui, M., Kosako, H., Natsuyama, R., Marutani, T., and *Fujiki, Y. (*: corresponding author)
    • Journal Title

      bioRxiv (eLife, in revision)

      Volume: -

    • DOI

      10.1101/2020.05.01.072132

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular basis of mitochondrial and peroxisomal division machineries.2020

    • Author(s)
      Imoto, Y. and *Fujiki, Y.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitotic phosphorylation of Pex14p regulates peroxisomal import machinery in mammals.2020

    • Author(s)
      Yamashita, K., Tamura, S., Honsho, M., Yada, H., Yagita, Y., Kosako, H., and *Fujiki, Y.
    • Journal Title

      J. Cell Biol.

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular basis of local energy generation during mitochondrial and peroxisomal division.2020

    • Author(s)
      Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and *Fujiki, Y.
    • Journal Title

      Plant Morphol.

      Volume: in press

    • NAID

      130008006485

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent insights into peroxisome biogenesis and associated diseases2020

    • Author(s)
      *Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, A.J., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W.K., and Kuroiwa, T.
    • Journal Title

      J. Cell Sci.

      Volume: 133 Issue: 9 Pages: 236943-236943

    • DOI

      10.1242/jcs.236943

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway2020

    • Author(s)
      Abe Yuichi、Honsho Masanori、Kawaguchi Ryoko、Matsuzaki Takashi、Ichiki Yayoi、Fujitani Masashi、Fujiwara Kazushirou、Hirokane Masaaki、Oku Masahide、Sakai Yasuyoshi、Yamashita Toshihide、Fujiki Yukio
    • Journal Title

      Journal of Biological Chemistry

      Volume: - Issue: 16 Pages: 5321-5334

    • DOI

      10.1074/jbc.ra119.011989

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systematic identification of regulators of oxidative stress reveals non-canonical roles for peroxisomal import and the pentose phosphate pathway.2020

    • Author(s)
      Dubreuil, M.M., Morgens, D.W., Okumoto, K., Honsho, M., Contrepois, K., Lee-McMullen, B., Traber, G.M., Sood, R.S., Dixon, S.J., Snyder, M.P., *Fujiki, Y., and *Bassik, M.C.
    • Journal Title

      Cell Rep.

      Volume: 30 Issue: 5 Pages: 1417-1433

    • DOI

      10.1016/j.celrep.2020.01.013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of <i>Cyanidioschyzon merolae</i>2019

    • Author(s)
      Imoto, Y., Abe, Y., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 95 Issue: 2 Pages: 75-85

    • DOI

      10.2183/pjab.95.007

    • NAID

      130007591938

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2019-02-08
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes2019

    • Author(s)
      Koyano Fumika、Yamano Koji、Kosako Hidetaka、Kimura Yoko、Kimura Mayumi、Fujiki Yukio、Tanaka Keiji、Matsuda Noriyuki
    • Journal Title

      EMBO reports

      Volume: 20 Issue: 12

    • DOI

      10.15252/embr.201947728

    • NAID

      120006942558

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasmalogen mediates integration of adherens junction2019

    • Author(s)
      Takahashi Takanori、Honsho Masanori、Abe Yuichi、Fujiki Yukio
    • Journal Title

      The Journal of Biochemistry

      Volume: 166 Issue: 5 Pages: 423-432

    • DOI

      10.1093/jb/mvz049

    • NAID

      40022069621

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum2019

    • Author(s)
      Honsho Masanori、Dorninger Fabian、Abe Yuichi、Setoyama Daiki、Ohgi Ryohei、Uchiumi Takeshi、Kang Dongchon、Berger Johannes、Fujiki Yukio
    • Journal Title

      The Journal of Biochemistry

      Volume: 166 Issue: 4 Pages: 353-361

    • DOI

      10.1093/jb/mvz043

    • NAID

      40022023663

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis.2019

    • Author(s)
      Tanaka, H., *Okazaki, T., Aoyama, S., Yokota, M., Koike, M., Okada, Y., Fujiki, Y., and Gotoh, Y.
    • Journal Title

      J. Cell Sci.

      Volume: - Issue: 11

    • DOI

      10.1242/jcs.224766

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder.2019

    • Author(s)
      Tanaka, A. J., Okumoto, K., Tamura, S., Abe, Y., Hirsch, Y., Deng, L., Ekstein, J., Chung, W. K., and Fujiki Y.
    • Journal Title

      Cold Spring Harb. Mol. Case Stud.

      Volume: 5 Issue: 1 Pages: 1-16

    • DOI

      10.1101/mcs.a003483

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The cytosolic peroxisome-targeting signal (PTS)-receptors, Pex7p and Pex5pL, are sufficient to transport PTS2 proteins to peroxisomes2019

    • Author(s)
      Mukai Satoru、Matsuzaki Takashi、Fujiki Yukio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1866 Issue: 3 Pages: 441-449

    • DOI

      10.1016/j.bbamcr.2018.10.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of peroxisome homeostasis and functions2018

    • Author(s)
      本庄 雅則、藤木 幸夫
    • Journal Title

      生化学

      Volume: 90 Issue: 1 Pages: 5-13

    • DOI

      10.14952/SEIKAGAKU.2018.900005

    • ISSN
      0037-1017
    • Year and Date
      2018-02-25
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes2018

    • Author(s)
      Imoto Yuuta、Abe Yuichi、Honsho Masanori、Okumoto Kanji、Ohnuma Mio、Kuroiwa Haruko、Kuroiwa Tsuneyoshi、Fujiki Yukio
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41467-018-07009-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum2018

    • Author(s)
      Abe Yuichi、Honsho Masanori、Itoh Ryota、Kawaguchi Ryoko、Fujitani Masashi、Fujiwara Kazushirou、Hirokane Masaaki、Matsuzaki Takashi、Nakayama Keiko、Ohgi Ryohei、Marutani Toshihiro、Nakayama Keiichi I、Yamashita Toshihide、Fujiki Yukio
    • Journal Title

      Life Science Alliance

      Volume: 1 Issue: 6 Pages: 1-17

    • DOI

      10.26508/lsa.201800062

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein.2018

    • Author(s)
      Niwa, H., Miyauchi-Nanri, Y., Okumoto, K., Mukai, S., Noi, K., Ogura, T., and Fujiki Y.
    • Journal Title

      J. Biochem.

      Volume: 164 Pages: 437-447

    • DOI

      10.1093/jb/mvy073

    • NAID

      40021789527

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes.2018

    • Author(s)
      Okumoto, K., Ono, T., Toyama, R., Shimomura, A., Nagata, A., and Fujiki Y.
    • Journal Title

      J. Cell Biol.

      Volume: 217 Issue: 2 Pages: 619-633

    • DOI

      10.1083/jcb.201708122

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation2017

    • Author(s)
      Hossain, Md. S., Abe, Y., Ali, F., Youssef, M., Honsho, M., Fujiki, Y., and *Katafuchi, T.
    • Journal Title

      J. Neurosci.

      Volume: 37 Issue: 15 Pages: 4074-4092

    • DOI

      10.1523/jneurosci.3941-15.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] BAK regulates catalase release from peroxisomes.2017

    • Author(s)
      *Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K., Cheng, E. H.
    • Journal Title

      Mol. Cell. Oncol.

      Volume: - Issue: 3 Pages: e1306610-e1306610

    • DOI

      10.1080/23723556.2017.1306610

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional complementation(version 3.0).2017

    • Author(s)
      *Fujiki, Y.
    • Journal Title

      Encyclopedia of Life Sciences

      Volume: - Pages: 1-6

    • DOI

      10.1002/9780470015902.a0005676.pub3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasmalogen homeostasis - regulation of plasmalogen biosynthesis and its physiological consequence in mammals2017

    • Author(s)
      Honsho Masanori、Fujiki Yukio
    • Journal Title

      FEBS Letters

      Volume: 591 Issue: 18 Pages: 2720-2729

    • DOI

      10.1002/1873-3468.12743

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 1)Peroxisome homeostasis: Physiology, Biogenesis and disorders. 2)Lipid homeostasis: Plasmalogens benefits to society.2019

    • Author(s)
      Y. Fujiki
    • Organizer
      2nd International Symposium on Current Advances in Peroxisome Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular complex coordinating peroxisome morphogenesis in mammalian cells2019

    • Author(s)
      Y. Fujiki, M. Honsho, K. Okumoto, Y. Abe, and Y. Imoto
    • Organizer
      NME 2019: 11th international congress of the NME/NDPK.NM23/AWD Gene Family
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Peroxisome homeostasis and biogenesis disorders2019

    • Author(s)
      Fujiki, Y., Hosoi, K., Miyata, N., Mukai, S., Okumoto, K., Cheng, E.H., Abe, Y., Honsho, M., Itoh, R., Nakayama, K., Nakayama, K.-I., and Yamashita, T.
    • Organizer
      NME 2019: 11th international congress of the NME/NDPK.NM23/AWD Gene Family
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Onsite GTP fueling via nucleoside-diphospate kinase drives constriction of mitochondria and peroxisomal division machineries2019

    • Author(s)
      Y. Imoto, Y. Abe, M. Honsho, K. Okumoto, M. Ohnuma, H. Kuroiwa, T. Kuroiwa, Y. Fujiki
    • Organizer
      NME 2019: 11th international congress of the NME/NDPK.NM23/AWD Gene Family
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ペルオキシソームマトリクスタンパク質輸送の分子機構2019

    • Author(s)
      藤木 幸夫、向井 悟
    • Organizer
      2019年度日本生化学会九州支部例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペルオキシソーム形成因子Pex14p の細胞分裂期特異的なリン酸化による機能制御機構 Mitotic regulation of peroxisomal import machinery by phosphorylation of Pex14p2019

    • Author(s)
      山下 昂一郎、田村 茂彦、藤木 幸夫
    • Organizer
      第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 個体におけるエーテル型リン脂質プラスマローゲンの生合成制御2019

    • Author(s)
      本庄 雅則、阿部 雄一、Dorninger Fabian、Berger Johannes、藤木 幸夫
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペルオキシソーム形成異常による小脳形態形成障害の病態発症機構2019

    • Author(s)
      阿部 雄一、本庄 雅則、伊藤 竜太、藤谷 昌司、中山 啓子、大城 遼平、中山 敬一、山下 俊英、藤木 幸夫
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペルオキシソーム欠損症病因遺伝子PEX26の新規変異同定とその障害の分子メカニズム2019

    • Author(s)
      田村 茂彦、奥本 寛治、Tanaka Akemi J.、阿部 雄一、Hirsch Yoel、Deng Liyong、Ekstein Joseph、Chung Wendy K.、藤木 幸夫
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 過酸化水素分解酵素カタラーゼの細胞内局在制御による酸化ストレス応答の分子機構2019

    • Author(s)
      藤木 幸夫、奥本 寛治、宮田 暖、Emily Cheng
    • Organizer
      第14回日本臨床ストレス応答学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Organizer, Introduction, and Conclusion / Workshop: Emerging concepts of inter-organelle communications in cell physiology 拡大するオルガネラコミュニケーションと細胞機能制御2019

    • Author(s)
      オーガナイザー: 岡崎 朋彦、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 過酸化水素誘導による Pex14pのリン酸化:カタラーゼのペルオキシソームへの輸送抑制と細胞の酸化ストレス耐性応答機構2019

    • Author(s)
      奥本 寛治、小迫 英尊、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペルオキシソーム局在性テイルアンカー型タンパク質ACBD5の翻訳アレストを介した局在化効率獲得2019

    • Author(s)
      小山 桂恵奈、奥本 寛治、田村 茂彦、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プラスマローゲン生合成を担うacyl/alkyl dihydroxyacetonephosphate reductaseの異なる細胞小器官への標的化とその生理的意義2019

    • Author(s)
      本庄 雅則、田中 恵美、Raphael A. Zoeller、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞分裂期特異的なペルオキシソーム形成因子Pex14pのリン酸化による機能制御解析2019

    • Author(s)
      山下 昂一郎、田村 茂彦、八木田 悠一、小迫 英尊、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] エーテルリン脂質プラスマローゲン依存的な上皮細胞の接着結合形成2019

    • Author(s)
      本庄 雅則、高橋 公紀、阿部雄一、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペルオキシソーム欠損症病因遺伝子PEX26の新規変異同定とその極軽度障害をもたらす分子メカニズム2019

    • Author(s)
      田村 茂彦、奥本 寛治、Akemi J. Tanaka、阿部 雄一、Yoel Hirsch、Liyong Deng、Joseph Ekstein、Wendy K. Chung、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペルオキシソーム欠損性アストロサイトにおける代謝障害とBDNF異常発現2019

    • Author(s)
      阿部 雄一、本庄 雅則、藤木 幸夫
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Peroxisome homeostasis: Tightly regulated import and export of matrix enzyme, catalase2019

    • Author(s)
      Yukio Fujiki
    • Organizer
      EMBO Workshop “Current advances in protein translocation across membranes”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pathological mechanism of peroxisome biogenesis disorders2019

    • Author(s)
      Yuichi Abe, Masanori Honsho, Ryota Itoh, Ryoko Kawaguchi, Masashi Fujitani, Kazushirou Fujiwara, Masaaki Hirokane, Takashi Matsuzaki, Keiko Nakayama, Ryohei Ohgi, Toshihiro Marutani, Keiichi I. Nakayama, Toshihide Yamashita, and Yukio Fujiki
    • Organizer
      EMBO Workshop “Current advances in protein translocation across membranes”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome homeostasis: Tightly regulated import and export of matrix enzyme, catalase2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biogenesis of peroxisomal tail-anchored membrane proteins, new splicing variants of Miro1, acyl-CoA binding domain containing protein 5 (ACBD5), and peroxin Pex26p2018

    • Author(s)
      Kanji Okumoto, Yuichi Yagita, Masanori Honsho, Yukio Fujiki
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maintenance and de novo formation of mammalian peroxisomes in the absence of membrane assembly peroxin, Pex16p2018

    • Author(s)
      Yuichi Yagita, Yukio Fujiki
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome homeostasis and human disorders2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      BIT's 8th Annual World Congress of Molecular & Cell Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peroxisome biogenesis, dysfunctions, and disorders2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      International Conference on Plasmalogen 2018 (ICP 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Local GTP fueling via nucleoside diphosphate kinase like protein DYNAMO1 drives division of peroxisome and mitochondrion2018

    • Author(s)
      Yukio Fujiki, Yuuta Imoto, Yuichi Abe, Masanori Honsho, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa
    • Organizer
      ASCB/EMBO 2018 Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペルオキシソームの細胞内移動の制御機構2018

    • Author(s)
      奥本寛治
    • Organizer
      「新生鎖の生物学」第5回若手ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pex14欠損マウスにおける小脳形態異常の分子機構2018

    • Author(s)
      阿部雄一 、本庄雅則 、藤木幸夫
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] テイルアンカー型タンパク質ACBD5 の 翻訳速度とペルオキシソームへの 輸送・局在化効率の関連性の検討2018

    • Author(s)
      小山桂恵奈、奥本寛治、田村茂彦、藤木幸夫
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソーム形成因子 Pex14p の細胞周期依存的なリン酸化による機能制御2018

    • Author(s)
      山下昂一郎、田村茂彦、藤木幸夫
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソームの構成酵素および膜タンパク質の局在性と生理機能制御2018

    • Author(s)
      藤木幸夫
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シンポジウム: コレステロールとプラスマローゲンのホメオスタシス機構と疾患2018

    • Author(s)
      藤木幸夫、佐藤隆一郎
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] プラスマローゲン依存的なコレステロール生合成調節とその障害による病態2018

    • Author(s)
      本庄 雅則、藤木 幸夫
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソーム形成因子 Pex14p の細胞周期依存的なリン酸化による機能制御メカニズムの解析2018

    • Author(s)
      山下昂一郎、田村茂彦、藤木幸夫
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 過酸化水素分解酵素カタラーゼの細胞内局在制御による酸化ストレス応答の分子機構2018

    • Author(s)
      藤木 幸夫、奥本 寛治、宮田 暖、Emily Cheng
    • Organizer
      第13回臨床ストレス応答学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新しく単離したPex7結合PTS2タンパク質P7BP2は新規ダイニンタイプAAA+である2018

    • Author(s)
      藤木 幸夫、丹羽 一、宮内(南里) 康弘、奥本 寛治、向井 悟、野井 健太郎、小椋 光、遠藤 斗志也
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ペルオキシソーム局在性テイルアンカー型膜タンパク質の輸送局在化機構2018

    • Author(s)
      奥本 寛治、田村 茂彦、八木田 悠一、本庄 雅則、藤木 幸夫
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ワークショップ :新生鎖オルガネラ膜タンパク質局在化と品質管理2018

    • Author(s)
      藤木幸夫、川原 裕之
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Lab overview; Drawer data2018

    • Author(s)
      Yukio Fujiki
    • Organizer
      New Horizons in Peroxisome Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pex5-Ub化によるTraffic制御とストレス応答2018

    • Author(s)
      藤木 幸夫
    • Organizer
      第1回ユビキチン研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Peroxisome Homeostasis, Dysfunctions, and Disorders2017

    • Author(s)
      Yukio Fujiki
    • Organizer
      8th International Conference and Exhibition on Metabolomics & Systems Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Peroxisome homeostasis: Protein translocation and quality control2017

    • Author(s)
      Yukio Fujiki
    • Organizer
      2017 Nascent Chain Biology International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] VDAC2-BAK axis regulates peroxisomal membrane permeability and catalase release2017

    • Author(s)
      Yukio Fujiki, Non Miyata, Satoru Mukai, Kenichiro Hosoi, Kanji Okumoto, and Emily H. Cheng
    • Organizer
      Gordon Research Conference on Organellar Channels & Transporters
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bcl-2 ファミリータンパク質 BAK を介したペルオキシソーム膜透過性制御2017

    • Author(s)
      細井謙一郎、 宮田暖、 向井悟、 奥本寛治、 Emily Cheng、 藤木幸夫
    • Organizer
      平成29年度生化学会九州支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 過酸化水素分解酵素カタラーゼによる新たな酸化ストレス応答機構の発見 - アポトーシス因子BAKの標的膜依存的な死と生の振り分け - VDAC2-BAK axis regulates peroxisomal membrane permeability and catalase release2017

    • Author(s)
      Yukio Fujiki, Non Miyata, Satoru Mukai, Kanji Okumoto, and Emily H. Cheng
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プラスマローゲン生合成機構:acyl/alkyl dihydroxyacetonephosphate還元酵素(DHRS7B)のペルオキシソームと小胞体への標的化機構 Acyl/alkyl dihydroxyacetonephosphate reductase (DHRS7B) targets to peroxisomes by a Pex19p-dependent class I pathway2017

    • Author(s)
      田中恵美、 本庄雅則、 藤木幸夫
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NDR2 のペルオキシソーム膜への局在と一次繊毛形成における役割 Localization of NDR2 to Peroxisomes and Its Role in ciliogenesis2017

    • Author(s)
      増川萌瑛 、 阿部彰子、 永井友朗、 奥本寛治、 本間悠太、 藤木幸夫、 水野健作
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エーテルリン脂質プラスマローゲンの生合成を制御するセンシング機構2017

    • Author(s)
      本庄雅則、 阿部雄一、 藤木幸夫
    • Organizer
      第59回日本脂質生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペルオキソソームの恒常性:膜およびマトリックスタンパク質輸送の分子基盤Peroxisome biogenesis: Import of nascent membrane and matrix proteins2017

    • Author(s)
      Yukio Fujiki, Kanji Okumoto, Yuichi Yagita, and Shigehiko Tamura
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 過酸化水素分解酵素カタラーゼによる新たな酸化ストレス応答機構の発見 ~アポトーシス因子BAKの標的膜依存的細胞死と生の振り分け~2017

    • Author(s)
      藤木幸夫、 細井謙一郎、 宮田暖、 向井悟、 奥本寛治、 Emily Cheng
    • Organizer
      第12回臨床ストレス応答学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペルオキシソームの機能と細胞内配置・運動性の新たな制御機構2017

    • Author(s)
      奥本 寛治、小野 立晃、外山 隆介、細井 謙一郎、宮田 暖、向井 悟、Emily H. Cheng、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] エーテルリン脂質プラスマローゲンの恒常性維持機構とその生理的意義2017

    • Author(s)
      本庄 雅則、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] PEX14障害マウスにおける小脳形態異常2017

    • Author(s)
      阿部 雄一、本庄 雅則、大城 遼平、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペルオキシソーム膜透過装置複合体の同定と輸送メカニズムの解明2017

    • Author(s)
      田村 茂彦、河村 優子、藤木 幸夫
    • Organizer
      2017年度 生命科学系学会合同年次大会ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Book] Peroxisome: metabolic functions and biogenesis. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases2020

    • Author(s)
      Okumoto, K., Tamura, S., Honsho, M., and *Fujiki, Y.
    • Publisher
      Springer Nature
    • Related Report
      2019 Annual Research Report
  • [Book] Peroxisome biogenesis disorders. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases2020

    • Author(s)
      Honsho, M., Okumoto, K., Tamura, S., and *Fujiki, Y.
    • Publisher
      Springer Nature
    • Related Report
      2019 Annual Research Report
  • [Book] A mouse model system to study peroxisomal roles in neurodegeneration of peroxisome biogenesis disorders. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases2020

    • Author(s)
      Abe, Y., Tamura, S., Honsho, M., and *Fujiki, Y.
    • Publisher
      Springer Nature
    • Related Report
      2019 Annual Research Report
  • [Book] 医学のあゆみ 特集「脂質クオリティ研究の基礎と臨床」 プラスマローゲン恒常性とその障害による疾患2019

    • Author(s)
      本庄 雅則、藤木 幸夫
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2019 Annual Research Report
  • [Book] Encyclopedia of Food Chemistry2019

    • Author(s)
      Honsho, M. and Fujiki, Y.
    • Total Pages
      16
    • Publisher
      Elsevier Inc.
    • ISBN
      9780128140451
    • Related Report
      2018 Annual Research Report
  • [Book] 生化学 特集:オルガネラの生物機能と疾患における破綻機構2018

    • Author(s)
      本庄雅則、藤木幸夫
    • Total Pages
      9
    • Publisher
      公益社団法人日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Book] 生体の科学 特集:細胞高次機能をつかさどるオルガネラコミュニケーション2018

    • Author(s)
      藤木幸夫、奥本寛治、本庄雅則
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2018 Annual Research Report
  • [Book] 医学のあゆみ 蛋白質代謝医学-構造・機能の研究から臨床応用まで2018

    • Author(s)
      藤木幸夫、奥本寛治
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2018 Annual Research Report
  • [Book] 実験医学 2017年7月号2017

    • Author(s)
      藤木幸夫, 山下俊一, 奥本寛治, 本庄雅則
    • Total Pages
      8
    • Publisher
      羊土社
    • ISBN
      9784758101653
    • Related Report
      2017 Annual Research Report
  • [Remarks] オルガネラホメオスタシス研究室

    • URL

      http://www.organelle.kyushu-u.ac.jp/lab/organellestasis/top.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 生体防御医学研究所 オルガネラホメオスタシス研究室

    • URL

      http://www.organelle.kyushu-u.ac.jp/lab/organellestasis/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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