Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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Outline of Final Research Achievements |
Mitochondria with low membrane potential are eliminated by autophagy, which is called mitochondrial quality control. It is still unclear how the mitochondrial quality control is regulated by cellular signals. We have focused on PKA-dependent phosphorylation and determined that intracellular localization of the PKA catalytic subunit isoforms. Furthermore, we found a role of the enzyme in the glycolytic pathway in mitochondrial quality control.
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