| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
The molecular mechanism of abnormal HOX (homeobox) gene expression in acute leukemia remains largely elusive. In this study, we found that leukemia-related proteins such as nucleoporin fusion proteins and mutant NPM1 are recruited to HOX cluster regions through their interaction with a nuclear export factor, CRM1, in human leukemia cell lines. Furthermore, our results showed that the transcriptional activation of HOX genes occurs in a CRM1-dependent manner in these cells.
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