| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
The purpose of this study is to reveal the physiological function of the lipid mediator, sphingosine-1-phosphate (S1P) during zebrafish organogenesis. We have established exhaustive S1PR knockout fish mediated by genome editing technologies and investigated the phenotypic analyses of these mutants. 7S1PR mutant, which was disrupted in all S1PRs, exhibited embryonic lethal. 7S1PR mutant showed not only cardia bifida like S1PR2 mutant, but also hypoplasia of vascular and erythroid cells. These results indicate that S1P signal plays important roles in hematopoietic and vascular development.
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