| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
|---|
| Outline of Final Research Achievements |
Correctness is an important feature of development. In developing embryos, however, behaviors and states of individual cells are highly variable. Thus, it has been a question how embryos achieve correct development by overcoming developmental variations/fluctuations. In this study, we have found that during formation of pluripotent epiblast cells in preimplantation mouse embryos, variations in Hippo signaling cause variable expression of pluripotency factors among cells, and that a quality control mechanism, which eliminates the low-quality/low pluripotency factor cells by apoptosis through short-range inter-cellular communication known as cell competition, is present. We propose that this is a mechanism, which overcomes variations during cell differentiation and supports correct developmen.
|
