Pattern formation through cell cluster formation and interaction
| Project/Area Number |
17H03683
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
|---|
| Keywords | パターン形成 / 細胞間相互作用 / ゼブラフィッシュ / ギャップ結合 / 体表模様 / 形態形成 / 電気生理 / 色素細胞 / 細胞・組織 / 発生・分化 / 遺伝子 / 動物 / 蛋白質 |
|---|
| Outline of Final Research Achievements |
During development and organogenesis, cells form populations with defined size and shape and form the boundaries between different cell populations. In this process, cell-cell interactions between cells of the same and different types play an important role. In this study, I focused on the body surface pattern of zebrafish and clarified the formation mechanism of the boundary between black and yellow pigment cells, each of which forms a population and has a certain size, and the boundary between black and yellow pigment cells (repeated structure and pattern). We focused on connexins, gap junction proteins, as important molecules involved in cell-cell interactions and analyzed their functions in pigment cells.
|
| Academic Significance and Societal Importance of the Research Achievements |
生物の形態形成において、等間隔性や繰り返し構造といったある種のパターンが存在する。多くの場合、構成する細胞間の相互作用により細胞自律的にパターン形成が行われる。本研究では、ゼブラフィッシュの体表模様をターゲットに、細胞自律的パターン形成の分子メカニズムの解明を目指した研究を行った。体表模様を形成する２種類の色素細胞、黒色素細胞と黄色素細胞の間には、細胞間をつなぐ２種類のチャネル分子が発現し、パターン音形成、安定化に寄与している。今回の研究により、黒色素細胞と黄色素細胞の間にはチャネル分子の機能に依存した、電気回路のようなシグナルの伝搬様式があることが分かってきた。
|
Report
(5 results)
Research Products
(15 results)
-
-
-
-
-
[Journal Article] The Genetic Basis of Morphological Diversity in Domesticated Goldfish2020
Author(s)
Kon Tetsuo、Omori Yoshihiro、Fukuta Kentaro、Wada Hironori、Watanabe Masakatsu、Chen Zelin、Iwasaki Miki、Mishina Tappei、Matsuzaki Shin-ichiro S.、Yoshihara Daiki、Arakawa Jumpei、Kawakami Koichi、Toyoda Atsushi、Burgess Shawn M.、Noguchi Hideki、Furukawa Takahisa
-
Journal Title
Current Biology
Volume: 30
Issue: 12
Pages: 2260-2274.e6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence.2019
Author(s)
Denis, J. F., Diagbouga, M. R., Molica, F., Hautefort, A., Linnerz, T., Watanabe, M., Lemeille, S., Bertrand, J. Y., and Kwak, B. R
-
Journal Title
Front Physiol
Volume: 10
Pages: 80-80
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
