| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|
|---|
| Outline of Final Research Achievements |
One of the ultimate goals of this research field is to achieve organ-level regeneration in a regeneration incompetent animal. To achieve this, we are referring to regeneration competent animals inorder to elucidate their trick of regeneration competency. The nerves play a central role in their regeneration processes. No nerves mean no regeneration in urodele amphibians. We successfully identified the nerve factors in amphibian limb regeneration. BMP7+FGF2+FGF8 are the nerve factors, which can induce limb regeneration. In the present study, we also revealed that the same factors could induce gill regeneration. We also tested whether the same molecules can trigger limb regeneration in chick embryos. Moreoever, we also could find that “embryolization” takes place in the early phase of limb regeneration in Xenopus froglet limbs. Those findings might contribute to understandings of organ-level regeneration potency.
|
