| Budget Amount *help |
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Localization of iodine in Arenibacter sp. SCT was found to be the membrane fraction, in which iodine was bound to a tyrosine residue of a protein annotated as PAP2 family protein. The PAP2 family is known to include histidine phosphatases and vanadium-dependent haloperoxidases (vHPOs), and the iodinated protein of strain C-21 formed a distinct clade within the vHPOs. Further study is needed to fully understand the function of iodine accumulated in strain C-21.
Dissimilatory iodate reductase (Idr) of Pseudomonas sp. SCT was identified by multiple proteomic and transcriptomic analyses as well as by the construction of a deletion mutant. The large subunit of Idr (IdrA) was a novel member of the DMSO reductase family. It was also suggested that both O2 and H2O2 are formed as by-products of iodate respiration. An electron transport chain model of strain SCT, in which iodate, H2O2, and O2 are used as terminal electron acceptors, was proposed.
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