| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
Bacteriocins were discovered from newly isolated lactic acid bacteria (LAB), and some of them were identified as novel bacteriocins by structural analysis of purified bacteriocins and draft genome analysis of the producer LAB isolates. Among the various bacteriocins we previously discovered and identified, some circular bacteriocins were analyzed for their biosynthetic genes and proteins, and their mechanisms for self-immunity, secretion, and circularization were characterized. A multiple bacteriocin transporter was characterized for the substrate specificity, and its availability for secretion of various bacteriocins was demonstrated. A species-specific bacteriocin was characterized for the biosynthesis and action mechanisms.
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