| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
In the Pib2 pathway, which is the Gtr/Rag-independent glutamine-responsive TORC1 activation mechanism in yeast, the vacuolar protein Pib2 changes its structure upon biding to glutamine and thereby binds to and activates TORC1. In addition, the glutamine-responsive TORC1 activation was reconstituted in vitro solely using Pib2 and TORC1. These observations indicate that Pib2 is the glutamine sensor as well as the direct activator of TORC1 in the Pib2 pathway.
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