| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Total synthetic studies on amycolamicin and nonthmicin, natural products with potent and broad-spectrum antibacterial activity against various drug-resistant bacteria, as well as actinoallolide A, a natural product with potent anti-trypanosomal activity, were conducted for the purpose of developing new categories of anti-infective drugs. The A, C, D, and E units of amycolamicin have been synthesized and the assembly of the C, D, and E units has been successfully achieved. The final stage of the total synthesis is now under progress. The 12-membered macrolactone part and the side chain moiety of actionallolide A have also been synthesized and the completion of the total synthesis by Suzuki-Miyaura coupling of the two parts is now underway.
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