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Search for novel functionalities of rice endosperm protein/bran protein and analysis of their mechanisms

Research Project

Project/Area Number 17H03816
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionNiigata Institute of Technology (2018-2019)
Niigata University (2017)

Principal Investigator

Kadowaki Motoni  新潟工科大学, 工学部, 教授 (90126029)

Co-Investigator(Kenkyū-buntansha) 久保田 真敏  新潟工科大学, 工学部, 准教授 (00595879)
藤村 忍  新潟大学, 自然科学系, 教授 (20282999)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords米タンパク質 / 生活習慣病 / 肥満 / ミネラル・骨代謝異常 / アレルギー
Outline of Final Research Achievements

In order to discover the novel functionalities of rice, proteins from rice endsperm (REP) and rice bran (RBP) were investigated to show the following significant effects for health. REP and RBP were shown to suppress the obesity, body weight gain and some adipose tissue weight, in C57BL/6 mice fed with a high fat diet. By using type 2 diabetic ZDF rats, RBP showed to alleviate deterioration of bone microstructures and bone strength of diabetic rats. Finally, by using BALB/c mice, REP showed the induction of skewing toward Th1, and the suppression of total blood IgE and antigen-specific IgE concentrations, indicating anti-allergic property.

Academic Significance and Societal Importance of the Research Achievements

米は我が国で唯一の自給可能な穀物であり、長らく食料自給率の維持に貢献してきた。けれども、その消費量は近年、減少の一途を辿り、現在ではピーク時から半減している。そこで、米の魅力として、美味しさに加えて健康に対する機能性を新たに発掘することができれば、米に対する消費者の意識は大きく変わり、消費量の増加を期待することができる。これはすなわち、我が国の農業、そして食料自給率の改善に大きく寄与することは間違いない。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (17 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Kasetsart University(Thailand)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Young rice protein as a new source of low allergenic plant-base protein2020

    • Author(s)
      Thidarat Pantoa, Ivona Baricevic-Jones, Prisana Suwannaporn, Motoni Kadowaki, Masatoshi Kubota, Sittiruk Roytrakul, E.N. Clare Mills
    • Journal Title

      Journal of Cereal Science

      Volume: 93 Pages: 102970-102970

    • DOI

      10.1016/j.jcs.2020.102970

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rice bran protein ameliorates diabetes, reduces fatty liver, and has renoprotective effects in Zucker Diabetic Fatty rats2020

    • Author(s)
      Masatoshi Kubota, Reiko Watanabe, Michihiro Hosojima, Akihito Saito, Ai Sasou, Takehiro Masumura, Yukikazu Harada, Hiroyuki Hashimoto, Shinobu Fujimura, Motoni Kadowaki
    • Journal Title

      Journal of Functional Foods

      Volume: 70 Pages: 103981-103981

    • DOI

      10.1016/j.jff.2020.103981

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological Multifunctions of Rice Proteins of Endosperm and Bran2019

    • Author(s)
      Motoni Kadowaki, Masatoshi Kubota, Reiko Watanabe
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 65

    • NAID

      130007729788

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pre-germination at varying stages of embryonic growth length on chemical composition and protein profile of Thai rice (Oryza sativa L.)2018

    • Author(s)
      Kupkanchanakul W, Kadowaki M, Kubota M, Naivikul O.
    • Journal Title

      Agric Nat Res

      Volume: 52 Issue: 1 Pages: 59-65

    • DOI

      10.1016/j.anres.2018.05.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 「血漿アミノ酸濃度の基準範囲設定」に関する見解2018

    • Author(s)
      宮野 博、渭原 博、橋詰直孝、廣田晃一、桑 克彦、市原清志、安東敏彦、門脇基二、遠藤文夫、栃久保修。
    • Journal Title

      臨床化学

      Volume: 47 Pages: 64-73

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect and proposed mechanism of vitamin C modulating amino acid regulation of autophagic proteolysis.2017

    • Author(s)
      Md.Razaul Karim, Motoni Kadowaki
    • Journal Title

      Biochimie

      Volume: 142 Pages: 51-62

    • DOI

      10.1016/j.biochi.2017.08.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Randomized, Double-Blind, Crossover Pilot Trial of Rice Endosperm Protein Supplementation in Maintenance Hemodialysis Patients2017

    • Author(s)
      Hosojima Michihiro、Shimada Hisaki、Obi Yoshitsugu、Kuwahara Shoji、Kaseda Ryohei、Kabasawa Hideyuki、Kondo Hazuki、Fujii Mikio、Watanabe Reiko、Suzuki Yoshiki、Kadowaki Motoni、Miyazaki Shigeru、Saito Akihiko
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-017-18340-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] お米の化学 白米タンパク質の生理学的機能性2017

    • Author(s)
      久保田 真敏、門脇 基二
    • Journal Title

      食と医療

      Volume: 1 Pages: 32-39

    • Related Report
      2017 Annual Research Report
  • [Presentation] 米胚乳タンパク質が2型糖尿病モデルZDFラットのCKD-MBDに与える影響2017

    • Author(s)
      久保田真敏、菅木省吾、渡邊令子、細島康宏、斎藤亮彦、樋口裕樹、藤井幹夫、笹川一郎、藤村忍、門脇基二
    • Organizer
      日本栄養・食糧学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 低リジン飼料による鶏肉の呈味性アミノ酸の増強2017

    • Author(s)
      半澤拓夢、渡邊源哉、金野健一郎、甲斐慎一、久保田真敏、門脇基二、藤村忍
    • Organizer
      日本栄養・食糧学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ステージ別による慢性腎臓病(CKD)患者のたんぱく質およびりん摂取量とその食品群の関連2017

    • Author(s)
      村松芳多子、渡邊令子、林祐美、細島康宏、門脇基二、斎藤亮彦
    • Organizer
      日本栄養・食糧学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of different amylose content on the quality of Funori (Gloiopeltis furcata) added rice noodles2017

    • Author(s)
      Tomoko Yamaguchi, Nami Horita, Mizuki Niwano, Satomi Eguchi, Yasuaki Enoki, Katsumi Sasagawa, Motoni Kadowaki
    • Organizer
      International Congress of Nutrition (IUNS 21th ICN, Buenos Aires, Argentina)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Beneficial effects of rice endosperm protein on chronic kidney disease-mineral and bone disorder (CKD-MBD) in Zucker diabetic fatty rats2017

    • Author(s)
      Reiko Watanabe, Masatoshi Kubota, Shogo Sugaki, Michihiro Hosojima, Akihiko Saito, Mikio Fujii, Ichiro Sasagawa, Shinobu Fujimura, Motoni Kadowaki
    • Organizer
      International Congress of Nutrition (IUNS 21th ICN, Buenos Aires, Argentina)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Beneficial effect of rice endosperm protein on IgE production2017

    • Author(s)
      Masatoshi Kubota, Takuya Kamada, Takashi Hara, Yuki Higuchi, Mikio Fujii, Shinji Sato, Shinobu Fujimura, Motoni Kadowaki
    • Organizer
      International Congress of Nutrition (IUNS 21th ICN, Buenos Aires, Argentina)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] Composition for suppressing fatty liver and rena hypertrophy due to diabetes and method for producing same2017

    • Inventor(s)
      Kadowaki M., Kubota M., et al.
    • Industrial Property Rights Holder
      Kadowaki M., Kubota M., et al.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 糖尿病による脂肪肝を抑制するための組成物及び糖尿病による腎肥大を抑制するための組成物2017

    • Inventor(s)
      門脇基二、久保田真敏、近藤尭、川上智子
    • Industrial Property Rights Holder
      門脇基二、久保田真敏、近藤尭、川上智子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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